Zygomycotic lymphadenitis in slaughtered feedlot cattle

J. Ortega, Francisco A Uzal, R. Walker, Hailu Kinde, Santiago S Diab, F. Shahriar, R. Pamma, A. Eigenheer, D. H. Read

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

During the 12 months of 2006, zygomycotic lymphadenitis was diagnosed in 194 of 198 feedlot steers (0.04% of cattle slaughtered during that period) in a California slaughterhouse as part of bovine tuberculosis surveillance. Mesenteric lymph nodes were involved in 190 cases. Affected lymph nodes were enlarged (2 to 42 cm in greatest dimension), firm, and mottled gray-white to yellow with multiple granular or caseocalcareous foci. Histologically, nodal architecture was effaced by necrosis, granulomatous inflammation, and fibrosis. In approximately 20% of the cases, granulomas were mainly restricted to subcapsular sinuses and afferent lymphatic vessels, causing granulomatous lymphangitis. Nonseptate, irregularly branching hyphae with nonparallel walls and bulbous enlargements were common in necrotic areas and within the cytoplasm of multinucleated giant cells. Fungal cultures were performed on 124 affected lymph nodes using 7 media, but no zygomycetes were cultured. Fungal DNA was amplified from 20 lymph nodes. Amplicons from 16 nodes had nearly 100% homology with sequences for Rhizomucor pusillus; 4 amplicons had (> 98%) homology with Absidia corymbifera sequences. Zygomycosis should be considered in the differential diagnosis for granulomatous lymphadenitis in feedlot steers.

Original languageEnglish (US)
Pages (from-to)108-115
Number of pages8
JournalVeterinary Pathology
Volume47
Issue number1
DOIs
StatePublished - 2010

Fingerprint

lymphadenitis
Lymphadenitis
feedlots
lymph nodes
Lymph Nodes
cattle
lymphangitis
Absidia
Fungal DNA
Rhizomucor pusillus
Rhizomucor
Absidia corymbifera
Lymphangitis
Zygomycosis
Bovine Tuberculosis
Abattoirs
Lymphatic Vessels
Hyphae
bovine tuberculosis
granuloma

Keywords

  • Absidia corymbifera
  • Bovine
  • Lymphadenitis
  • Mucormycosis
  • Rhizomucor pusillus
  • Zygomycosis

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Zygomycotic lymphadenitis in slaughtered feedlot cattle. / Ortega, J.; Uzal, Francisco A; Walker, R.; Kinde, Hailu; Diab, Santiago S; Shahriar, F.; Pamma, R.; Eigenheer, A.; Read, D. H.

In: Veterinary Pathology, Vol. 47, No. 1, 2010, p. 108-115.

Research output: Contribution to journalArticle

Ortega, J, Uzal, FA, Walker, R, Kinde, H, Diab, SS, Shahriar, F, Pamma, R, Eigenheer, A & Read, DH 2010, 'Zygomycotic lymphadenitis in slaughtered feedlot cattle', Veterinary Pathology, vol. 47, no. 1, pp. 108-115. https://doi.org/10.1177/0300985809352975
Ortega, J. ; Uzal, Francisco A ; Walker, R. ; Kinde, Hailu ; Diab, Santiago S ; Shahriar, F. ; Pamma, R. ; Eigenheer, A. ; Read, D. H. / Zygomycotic lymphadenitis in slaughtered feedlot cattle. In: Veterinary Pathology. 2010 ; Vol. 47, No. 1. pp. 108-115.
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