ZPK inhibits PKA induced transcriptional activation by CREB and blocks retinoic acid induced neuronal differentiation

Usha R. Reddy, Amitabha Basu, Peter Bannerman, Naohiko Ikegaki, C. Damodara Reddy, David E Pleasure

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Zipper Protein Kinase (ZPK) is a leucine zipper protein localized to the nucleus which exhibits serine-threonine kinase activity and is associated with the dependent signal transduction pathway. ZPK heterodimers with leucine zipper containing transcription factors such as the cyclic AMP responsive element binding protein (CREB) and Myc. Furthermore ZPK phosphorylates both Myc and CREB. Overexpression of ZPK in NTera-2 human teratocarcinoma cells results in inhibition of PKA induced transcriptional activation by CREB and prevents retinoic acid induced differentiation of the cells to neurons. Our results suggest that ZPK stifles neural differentiation of NT-2 cells partly due to its inhibitory effect on CREB function.

Original languageEnglish (US)
Pages (from-to)4474-4484
Number of pages11
JournalOncogene
Volume18
Issue number31
DOIs
StatePublished - Aug 5 1999
Externally publishedYes

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Keywords

  • CREB
  • NT2 differentiation
  • ZPK

ASJC Scopus subject areas

  • Molecular Biology
  • Cancer Research
  • Genetics

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