Zonisamide monotherapy for idiopathic epilepsy in dogs

J. Y. Chung, C. Y. Hwang, J. S. Chae, J. O. Ahn, T. H. Kim, Kyoung Won Seo, S. Y. Lee, H. Y. Youn

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

AIM: To evaluate the efficacy of zonisamide as a monotherapy in dogs with idiopathic epileptic seizure.METHODS: The experiment was conducted on 10 dogs with idiopathic epilepsy that were treated at the Seoul National University Hospital for Animals. A diagnosis was conducted based on physical and neurologic examination, complete blood count and chemical analysis, magnetic resonance imaging and cerebrospinal fluid analyses. Idiopathic epilepsy was diagnosed when all of these examinations were normal. Oral zonisamide was administrated to 10 dogs with idiopathic epilepsy at 5-15 mg/kg per os every 12 h to achieve a concentration of zonisamide in serum of 10-40 μg/mL. The frequency of seizures before and after the administration of zonisamide therapy was recorded and the concentrations of zonisamide in serum were measured.RESULTS: Six (60%) of the dogs were favourable responders to treatment, showing a ≥50% reduction in monthly frequency of seizures. Of the remaining four, two dogs did not show a reduction and the other two showed an increase in frequency of seizures. The mean dosage of zonisamide for favourable responders was 7.92 (SD 3.79) mg/kg, which was administered orally twice a day. Only one dog, which was one of the unfavourable responders in the whole study, experienced mild side effects.CONCLUSIONS: Among the dogs treated with oral zonisamide, 60% responded favourably. The effect of zonisamide as an anticonvulsant drug was demonstrated in this study.CLINICAL RELEVANCE: Based on these results, zonisamide monotherapy is effective in some dogs with idiopathic epilepsy.

Original languageEnglish (US)
Pages (from-to)357-359
Number of pages3
JournalNew Zealand Veterinary Journal
Volume60
Issue number6
DOIs
StatePublished - Nov 1 2012
Externally publishedYes

Fingerprint

zonisamide
epilepsy
Epilepsy
Dogs
dogs
seizures
Seizures
blood serum
mouth
Blood Chemical Analysis
anticonvulsants
veterinary clinics
cerebrospinal fluid
Blood Cell Count
magnetic resonance imaging
Neurologic Examination

Keywords

  • Dog
  • epilepsy
  • monotherapy
  • zonisamide

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Chung, J. Y., Hwang, C. Y., Chae, J. S., Ahn, J. O., Kim, T. H., Seo, K. W., ... Youn, H. Y. (2012). Zonisamide monotherapy for idiopathic epilepsy in dogs. New Zealand Veterinary Journal, 60(6), 357-359. https://doi.org/10.1080/00480169.2012.680855

Zonisamide monotherapy for idiopathic epilepsy in dogs. / Chung, J. Y.; Hwang, C. Y.; Chae, J. S.; Ahn, J. O.; Kim, T. H.; Seo, Kyoung Won; Lee, S. Y.; Youn, H. Y.

In: New Zealand Veterinary Journal, Vol. 60, No. 6, 01.11.2012, p. 357-359.

Research output: Contribution to journalArticle

Chung, JY, Hwang, CY, Chae, JS, Ahn, JO, Kim, TH, Seo, KW, Lee, SY & Youn, HY 2012, 'Zonisamide monotherapy for idiopathic epilepsy in dogs', New Zealand Veterinary Journal, vol. 60, no. 6, pp. 357-359. https://doi.org/10.1080/00480169.2012.680855
Chung, J. Y. ; Hwang, C. Y. ; Chae, J. S. ; Ahn, J. O. ; Kim, T. H. ; Seo, Kyoung Won ; Lee, S. Y. ; Youn, H. Y. / Zonisamide monotherapy for idiopathic epilepsy in dogs. In: New Zealand Veterinary Journal. 2012 ; Vol. 60, No. 6. pp. 357-359.
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