Zinc supplementation does not affect growth, morbidity, or motor development of US term breastfed infants at 4-10 mo of age

M. Jane Heinig, Kenneth H. Brown, Bo Lönnerdal, Kathryn G. Dewey

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Background: It has been documented that growth patterns differ between breastfed and formula-fed infants. Some investigators have suggested that these differences may be related to differences in zinc nutriture. Objective: The objective of this study was to examine the effect of zinc supplementation on growth, morbidity, and motor development in healthy, term, breastfed infants. Design: We conducted a randomized double-blind intervention comparing zinc supplementation (5 mg/d as zinc sulfate) with placebo in breastfed infants aged 4-10 mo. Growth and indexes of body composition and gross motor development were measured monthly from 3 to 10 mo. Morbidity data were collected weekly. Results: Eighty-five infants were enrolled, and 70 completed the study. The baseline characteristics, attained weight or length at 10 mo, growth velocity, gross motor development, and morbidity did not differ significantly between groups, even after control for potentially confounding variables. Conclusions: The dietary zinc intake of these breastfed infants appeared to be adequate, given that zinc supplementation did not affect growth, development, or risk of infection (although sample size for detection of differences in development or infection was limited). Previously described differences in growth between breastfed and formula-fed infants in such populations do not appear to be due to differences in zinc nutriture.

Original languageEnglish (US)
Pages (from-to)594-601
Number of pages8
JournalAmerican Journal of Clinical Nutrition
Volume84
Issue number3
StatePublished - Sep 1 2006

Fingerprint

motor development
morbidity
Zinc
zinc
Morbidity
Growth
Infant Formula
infant formulas
Zinc Sulfate
zinc sulfate
Confounding Factors (Epidemiology)
Infection
Body Composition
Growth and Development
infection
Sample Size
placebos
body composition
Placebos
Research Personnel

Keywords

  • Breastfeeding
  • Infant growth
  • Motor development
  • Randomized supplementation trial
  • Zinc

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Zinc supplementation does not affect growth, morbidity, or motor development of US term breastfed infants at 4-10 mo of age. / Heinig, M. Jane; Brown, Kenneth H.; Lönnerdal, Bo; Dewey, Kathryn G.

In: American Journal of Clinical Nutrition, Vol. 84, No. 3, 01.09.2006, p. 594-601.

Research output: Contribution to journalArticle

Heinig, M. Jane ; Brown, Kenneth H. ; Lönnerdal, Bo ; Dewey, Kathryn G. / Zinc supplementation does not affect growth, morbidity, or motor development of US term breastfed infants at 4-10 mo of age. In: American Journal of Clinical Nutrition. 2006 ; Vol. 84, No. 3. pp. 594-601.
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