Zinc status and interleukin-1β-induced alterations in mineral metabolism in rats

L. M. Bui, R. H. Dressendorfer, Carl L Keen, J. J. Summary, M. A. Dubick

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Changes in zinc (Zn) metabolism and interleukin-1β (IL-1β) release occur as part of the physiological response to tissue injury and trauma. In the present study, the influence of Zn status on the response to continuous low- dose IL-1β administration was evaluated. Rats were fed 50 μg Zn/g (adequate zinc; AZn) or 5 μg Zn/g (marginal zinc; MZn) diets for 14 days. On day 15, rats were infused via osmotic minipumps, with IL-1β (2.3 ng/hr) or saline (control, C) and euthanized 1, 3, or 7 days later. In the AZn rats, IL-1β infusion resulted in increased plasma copper (Cu) concentrations and ceruloplasmin (Cp) activity, and decreased iron (Fe) concentrations throughout the 7d period. These effects were most pronounced on d1 and d3. A similar trend was observed in the MZn rats, but IL-1β-induced increases in plasma Cu and Cp activity were less than in the AZn fed rats. In MZn and AZn IL-1β infused rats, plasma Zn was decreased on Day 1, and Day 3, respectively, compared with their respective controls. AZn IL-1β-infused rats were characterized by high liver Fe, Zn, and metallothionein (MT) concentrations on Day 1; by Day 7, only MT concentrations remained elevated. Liver MnSOD activity was 13%-29% higher in both the AZn- and MZn-IL-1β- infused rats than their respective controls on Day 3 and Day 7, with most significant increase observed on Day 7. These data show that Zn status can influence the response to low-dose IL-1β; this influence of Zn should be considered when IL-1β is given therapeutically.

Original languageEnglish (US)
Pages (from-to)438-444
Number of pages7
JournalProceedings of the Society for Experimental Biology and Medicine
Volume206
Issue number4
StatePublished - 1994

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Interleukin-1
Metabolism
Minerals
Zinc
Rats
Ceruloplasmin
Plasmas
Liver
Metallothionein
Wounds and Injuries
Nutrition
Copper
Iron
Tissue
Diet

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Bui, L. M., Dressendorfer, R. H., Keen, C. L., Summary, J. J., & Dubick, M. A. (1994). Zinc status and interleukin-1β-induced alterations in mineral metabolism in rats. Proceedings of the Society for Experimental Biology and Medicine, 206(4), 438-444.

Zinc status and interleukin-1β-induced alterations in mineral metabolism in rats. / Bui, L. M.; Dressendorfer, R. H.; Keen, Carl L; Summary, J. J.; Dubick, M. A.

In: Proceedings of the Society for Experimental Biology and Medicine, Vol. 206, No. 4, 1994, p. 438-444.

Research output: Contribution to journalArticle

Bui, LM, Dressendorfer, RH, Keen, CL, Summary, JJ & Dubick, MA 1994, 'Zinc status and interleukin-1β-induced alterations in mineral metabolism in rats', Proceedings of the Society for Experimental Biology and Medicine, vol. 206, no. 4, pp. 438-444.
Bui, L. M. ; Dressendorfer, R. H. ; Keen, Carl L ; Summary, J. J. ; Dubick, M. A. / Zinc status and interleukin-1β-induced alterations in mineral metabolism in rats. In: Proceedings of the Society for Experimental Biology and Medicine. 1994 ; Vol. 206, No. 4. pp. 438-444.
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