Abstract
Artificial transcription factors can be rapidly constructed from predefined zinc-finger modules to regulate virtually any gene. Stable, heritable up- and downregulation of endogenous genes has been demonstrated in transgenic plants. These advances promise new approaches for creating functional knockouts and conditional overexpression, and for other gene discovery and manipulation applications in plants.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 163-168 |
| Number of pages | 6 |
| Journal | Current Opinion in Plant Biology |
| Volume | 6 |
| Issue number | 2 |
| DOIs | |
| State | Published - Apr 2003 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Plant Science
Cite this
Zinc fingers and a green thumb : Manipulating gene expression in plants. / Segal, David; Stege, Justin T.; Barbas, Carlos F.
In: Current Opinion in Plant Biology, Vol. 6, No. 2, 04.2003, p. 163-168.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Zinc fingers and a green thumb
T2 - Manipulating gene expression in plants
AU - Segal, David
AU - Stege, Justin T.
AU - Barbas, Carlos F.
PY - 2003/4
Y1 - 2003/4
N2 - Artificial transcription factors can be rapidly constructed from predefined zinc-finger modules to regulate virtually any gene. Stable, heritable up- and downregulation of endogenous genes has been demonstrated in transgenic plants. These advances promise new approaches for creating functional knockouts and conditional overexpression, and for other gene discovery and manipulation applications in plants.
AB - Artificial transcription factors can be rapidly constructed from predefined zinc-finger modules to regulate virtually any gene. Stable, heritable up- and downregulation of endogenous genes has been demonstrated in transgenic plants. These advances promise new approaches for creating functional knockouts and conditional overexpression, and for other gene discovery and manipulation applications in plants.
UR - http://www.scopus.com/inward/record.url?scp=0037394848&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037394848&partnerID=8YFLogxK
U2 - 10.1016/S1369-5266(03)00007-4
DO - 10.1016/S1369-5266(03)00007-4
M3 - Article
C2 - 12667874
AN - SCOPUS:0037394848
VL - 6
SP - 163
EP - 168
JO - Current Opinion in Plant Biology
JF - Current Opinion in Plant Biology
SN - 1369-5266
IS - 2
ER -