Zinc deficiency and neurodevelopment

The case of neurons

Ana M. Adamo, Patricia I. Oteiza

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Zinc is essential for normal brain development. Gestational severe zinc deficiency can lead to overt fetal brain malformations. Although not teratogenic, suboptimal zinc nutrition during gestation can have long-term effects on the offspring's nervous system. This article will review current knowledge on the role of zinc in modulating neurogenesis and neuronal apoptosis as well as the proposed underlying mechanisms. A decrease in neuronal zinc causes cell cycle arrest, which in part involves a deregulation of select signals (ERK1/2, p53, and NF-κB). Zinc deficiency also induces apoptotic neuronal death through the intrinsic (mitochondrial) pathway, which can be triggered by the activation of the zincregulated enzyme caspase-3, and as a consequence of abnormal regulation of prosurvival signals (ERK1/2 and NF-κB). Alterations in the finely tuned processes of neurogenesis, neuronal migration, differentiation, and apoptosis, which involve the developmental shaping of the nervous system, could have a long-term impact on brain health. Zinc deficiency during gestation, even at the marginal levels observed in human populations, could increase the risk for behavioral/ neurological disorders in infancy, adolescence, and adulthood.

Original languageEnglish (US)
Pages (from-to)117-124
Number of pages8
JournalBioFactors
Volume36
Issue number2
DOIs
StatePublished - 2010

Fingerprint

Neurons
Zinc
Brain
Neurogenesis
Neurology
Nervous System
Apoptosis
Pregnancy
Enzyme Activation
Deregulation
Nutrition
Cell Cycle Checkpoints
Nervous System Diseases
Caspase 3
Chemical activation
Cells
Health
Enzymes
Population

Keywords

  • Apoptosis
  • Bad
  • Caspase
  • ERK
  • Neuron
  • NF-κB
  • P53
  • Proliferation
  • Zinc
  • Zinc deficiency

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Molecular Medicine

Cite this

Zinc deficiency and neurodevelopment : The case of neurons. / Adamo, Ana M.; Oteiza, Patricia I.

In: BioFactors, Vol. 36, No. 2, 2010, p. 117-124.

Research output: Contribution to journalArticle

Adamo, Ana M. ; Oteiza, Patricia I. / Zinc deficiency and neurodevelopment : The case of neurons. In: BioFactors. 2010 ; Vol. 36, No. 2. pp. 117-124.
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