Abstract
Zinc is essential for the normal development and function of the nervous system. In humans, and depending on the developmental stage, zinc deficiency affects infant behavior, cognition, and motor performance [1-6]. In this regard, low plasma zinc values were found to be associated with altered cognition and emotional functioning in three rural communities of low-income 3- to 5-year-old children in the United States [7] and with pregnancy complications and altered child psychomotor development in a population from central Russia [8]. Low plasma zinc concentrations are also correlated with the occurrence of inattentive symptoms in children with attention/hyperactivity disorder [9]. Stressing the relevance of an adequate zinc nutrition for normal brain physiology, several studies have shown that zinc supplementation of undernourished children improves developmental quotients, activity patterns, and neuropsychological functions [2,3,6,10-12]. Given these data and the fact that the risk for zinc undernutrition is high throughout the world [13,14], the potential deleterious impact of zinc deficiency on brain development and function has to be considered of significant health concern in human populations.
| Original language | English (US) |
|---|---|
| Title of host publication | Micronutrients and Brain Health |
| Publisher | CRC Press |
| Pages | 149-161 |
| Number of pages | 13 |
| ISBN (Electronic) | 9781420073522 |
| ISBN (Print) | 9781420073515 |
| State | Published - Jan 1 2009 |
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ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Zinc and the cytoskeleton in neuronal signaling. / Mackenzie, Gerardo; Oteiza, Patricia I.
Micronutrients and Brain Health. CRC Press, 2009. p. 149-161.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Zinc and the cytoskeleton in neuronal signaling
AU - Mackenzie, Gerardo
AU - Oteiza, Patricia I.
PY - 2009/1/1
Y1 - 2009/1/1
N2 - Zinc is essential for the normal development and function of the nervous system. In humans, and depending on the developmental stage, zinc deficiency affects infant behavior, cognition, and motor performance [1-6]. In this regard, low plasma zinc values were found to be associated with altered cognition and emotional functioning in three rural communities of low-income 3- to 5-year-old children in the United States [7] and with pregnancy complications and altered child psychomotor development in a population from central Russia [8]. Low plasma zinc concentrations are also correlated with the occurrence of inattentive symptoms in children with attention/hyperactivity disorder [9]. Stressing the relevance of an adequate zinc nutrition for normal brain physiology, several studies have shown that zinc supplementation of undernourished children improves developmental quotients, activity patterns, and neuropsychological functions [2,3,6,10-12]. Given these data and the fact that the risk for zinc undernutrition is high throughout the world [13,14], the potential deleterious impact of zinc deficiency on brain development and function has to be considered of significant health concern in human populations.
AB - Zinc is essential for the normal development and function of the nervous system. In humans, and depending on the developmental stage, zinc deficiency affects infant behavior, cognition, and motor performance [1-6]. In this regard, low plasma zinc values were found to be associated with altered cognition and emotional functioning in three rural communities of low-income 3- to 5-year-old children in the United States [7] and with pregnancy complications and altered child psychomotor development in a population from central Russia [8]. Low plasma zinc concentrations are also correlated with the occurrence of inattentive symptoms in children with attention/hyperactivity disorder [9]. Stressing the relevance of an adequate zinc nutrition for normal brain physiology, several studies have shown that zinc supplementation of undernourished children improves developmental quotients, activity patterns, and neuropsychological functions [2,3,6,10-12]. Given these data and the fact that the risk for zinc undernutrition is high throughout the world [13,14], the potential deleterious impact of zinc deficiency on brain development and function has to be considered of significant health concern in human populations.
UR - http://www.scopus.com/inward/record.url?scp=85057656159&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85057656159&partnerID=8YFLogxK
M3 - Chapter
AN - SCOPUS:85057656159
SN - 9781420073515
SP - 149
EP - 161
BT - Micronutrients and Brain Health
PB - CRC Press
ER -