Zinc and the aging brain

Johnathan R. Nuttall, Patricia I. Oteiza

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Abstract: Alterations in trace element homeostasis could be involved in the pathology of dementia, and in particular of Alzheimer's disease (AD). Zinc is a structural or functional component of many proteins, being involved in numerous and relevant physiological functions. Zinc homeostasis is affected in the elderly, and current evidence points to alterations in the cellular and systemic distribution of zinc in AD. Although the association of zinc and other metals with AD pathology remains unclear, therapeutic approaches designed to restore trace element homeostasis are being tested in clinical trials. Not only could zinc supplementation potentially benefit individuals with AD, but zinc supplementation also improves glycemic control in the elderly suffering from diabetes mellitus. However, the findings that select genetic polymorphisms may alter an individual's zinc intake requirements should be taken into consideration when planning zinc supplementation. This review will focus on current knowledge regarding pathological and protective mechanisms involving brain zinc in AD to highlight areas where future research may enable development of new and improved therapies.

Original languageEnglish (US)
Article number379
JournalGenes and Nutrition
Volume9
Issue number1
DOIs
StatePublished - Jan 2014

Fingerprint

Zinc
Brain
Alzheimer Disease
Homeostasis
Trace Elements
Pathology
Genetic Polymorphisms
Psychological Stress
Dementia
Diabetes Mellitus
Metals
Clinical Trials
Therapeutics
Proteins

Keywords

  • Aging brain
  • Alzheimer's disease
  • Diabetes
  • Nutrigenomics
  • Zinc

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Genetics

Cite this

Nuttall, J. R., & Oteiza, P. I. (2014). Zinc and the aging brain. Genes and Nutrition, 9(1), [379]. https://doi.org/10.1007/s12263-013-0379-x

Zinc and the aging brain. / Nuttall, Johnathan R.; Oteiza, Patricia I.

In: Genes and Nutrition, Vol. 9, No. 1, 379, 01.2014.

Research output: Contribution to journalArticle

Nuttall, JR & Oteiza, PI 2014, 'Zinc and the aging brain', Genes and Nutrition, vol. 9, no. 1, 379. https://doi.org/10.1007/s12263-013-0379-x
Nuttall, Johnathan R. ; Oteiza, Patricia I. / Zinc and the aging brain. In: Genes and Nutrition. 2014 ; Vol. 9, No. 1.
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