Abstract
The trace element zinc is essential to a diverse array of structural, catalytic, and regulatory functions in mammals. With no known storage form of this element, zinc deficiency is rapidly induced in animal models, and, in humans, zinc deficiency contributes to reduced growth and immune function. While severe zinc deficiency is not common in the developed world, marginal zinc deficiency could contribute to a number of disease states. Current research is focused on understanding the cellular regulation of zinc including intracellular transporters that shuttle zinc within organelles, and between cells and the extracellular space, and the role of zinc in human health.
| Original language | English (US) |
|---|---|
| Title of host publication | Present Knowledge in Nutrition: Tenth Edition |
| Publisher | Wiley-Blackwell |
| Pages | 521-539 |
| Number of pages | 19 |
| ISBN (Print) | 9780470959176 |
| DOIs | |
| State | Published - Jun 18 2012 |
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Keywords
- Cellular regulation of zinc, intracellular, shuttling zinc within organelles
- Food components, as phytate affecting zinc absorption
- Marginal zinc deficiency and disease states
- Pathophysiological abnormalities, secondary zinc deficiency
- Physiological processes, on metabolism and regulatory roles of zinc
- Physiological, zinc in catalytic, co-catalytic or structural fashion
- Trace element zinc, in structural, catalytic, regulatory functions
- Zinc for absorption, from diet and endogenous sources of zinc
- Zinc metabolism on several fronts, the gaps in zinc metabolism
- Zinc-deficiency, changes in cell signaling and alterations in immune system
ASJC Scopus subject areas
- Medicine(all)
Cite this
Zinc. / Holt, Roberta R.; Uriu-Adams, Janet Y.; Keen, Carl L.
Present Knowledge in Nutrition: Tenth Edition. Wiley-Blackwell, 2012. p. 521-539.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Zinc
AU - Holt, Roberta R.
AU - Uriu-Adams, Janet Y.
AU - Keen, Carl L
PY - 2012/6/18
Y1 - 2012/6/18
N2 - The trace element zinc is essential to a diverse array of structural, catalytic, and regulatory functions in mammals. With no known storage form of this element, zinc deficiency is rapidly induced in animal models, and, in humans, zinc deficiency contributes to reduced growth and immune function. While severe zinc deficiency is not common in the developed world, marginal zinc deficiency could contribute to a number of disease states. Current research is focused on understanding the cellular regulation of zinc including intracellular transporters that shuttle zinc within organelles, and between cells and the extracellular space, and the role of zinc in human health.
AB - The trace element zinc is essential to a diverse array of structural, catalytic, and regulatory functions in mammals. With no known storage form of this element, zinc deficiency is rapidly induced in animal models, and, in humans, zinc deficiency contributes to reduced growth and immune function. While severe zinc deficiency is not common in the developed world, marginal zinc deficiency could contribute to a number of disease states. Current research is focused on understanding the cellular regulation of zinc including intracellular transporters that shuttle zinc within organelles, and between cells and the extracellular space, and the role of zinc in human health.
KW - Cellular regulation of zinc, intracellular, shuttling zinc within organelles
KW - Food components, as phytate affecting zinc absorption
KW - Marginal zinc deficiency and disease states
KW - Pathophysiological abnormalities, secondary zinc deficiency
KW - Physiological processes, on metabolism and regulatory roles of zinc
KW - Physiological, zinc in catalytic, co-catalytic or structural fashion
KW - Trace element zinc, in structural, catalytic, regulatory functions
KW - Zinc for absorption, from diet and endogenous sources of zinc
KW - Zinc metabolism on several fronts, the gaps in zinc metabolism
KW - Zinc-deficiency, changes in cell signaling and alterations in immune system
UR - http://www.scopus.com/inward/record.url?scp=84865773476&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84865773476&partnerID=8YFLogxK
U2 - 10.1002/9781119946045.ch34
DO - 10.1002/9781119946045.ch34
M3 - Chapter
AN - SCOPUS:84865773476
SN - 9780470959176
SP - 521
EP - 539
BT - Present Knowledge in Nutrition: Tenth Edition
PB - Wiley-Blackwell
ER -