Roberta R. Holt, Janet Y. Uriu-Adams, Carl L Keen

Research output: Chapter in Book/Report/Conference proceedingChapter

17 Scopus citations


The trace element zinc is essential to a diverse array of structural, catalytic, and regulatory functions in mammals. With no known storage form of this element, zinc deficiency is rapidly induced in animal models, and, in humans, zinc deficiency contributes to reduced growth and immune function. While severe zinc deficiency is not common in the developed world, marginal zinc deficiency could contribute to a number of disease states. Current research is focused on understanding the cellular regulation of zinc including intracellular transporters that shuttle zinc within organelles, and between cells and the extracellular space, and the role of zinc in human health.

Original languageEnglish (US)
Title of host publicationPresent Knowledge in Nutrition: Tenth Edition
Number of pages19
ISBN (Print)9780470959176
StatePublished - Jun 18 2012


  • Cellular regulation of zinc, intracellular, shuttling zinc within organelles
  • Food components, as phytate affecting zinc absorption
  • Marginal zinc deficiency and disease states
  • Pathophysiological abnormalities, secondary zinc deficiency
  • Physiological processes, on metabolism and regulatory roles of zinc
  • Physiological, zinc in catalytic, co-catalytic or structural fashion
  • Trace element zinc, in structural, catalytic, regulatory functions
  • Zinc for absorption, from diet and endogenous sources of zinc
  • Zinc metabolism on several fronts, the gaps in zinc metabolism
  • Zinc-deficiency, changes in cell signaling and alterations in immune system

ASJC Scopus subject areas

  • Medicine(all)


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