Zika virus and neurologic autoimmunity

The putative role of gangliosides

Juan Manuel Anaya, Carolina Ramirez-Santana, Ignacio Salgado-Castaneda, Christopher Chang, Aftab Ansari, M. Eric Gershwin

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

An increasing number of severe neurological complications associated with Zika virus (ZIKV), chiefly Guillain-Barré syndrome (GBS) and primary microcephaly, have led the World Health Organization to declare a global health emergency. Molecular mimicry between glycolipids and surface molecules of infectious agents explain most of the cases of GBS preceded by infection, while a direct toxicity of ZIKV on neural cells has been raised as the main mechanism by which ZIKV induces microcephaly. Gangliosides are crucial in brain development, and their expression correlates with neurogenesis, synaptogenesis, synaptic transmission, and cell proliferation. Targeting the autoimmune response to gangliosides may represent an underexploited opportunity to examine the increased incidence of neurological complications related to ZIKV infection.

Original languageEnglish (US)
Article number49
JournalBMC Medicine
Volume14
Issue number1
DOIs
StatePublished - Mar 21 2016

Fingerprint

Gangliosides
Autoimmunity
Nervous System
Microcephaly
Molecular Mimicry
Glycolipids
Neurogenesis
Synaptic Transmission
Emergencies
Cell Proliferation
Incidence
Brain
Infection
Zika Virus

Keywords

  • Autoimmunity
  • Gangliosides
  • Guillain-Barré syndrome
  • Microcephaly
  • Zika virus

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Anaya, J. M., Ramirez-Santana, C., Salgado-Castaneda, I., Chang, C., Ansari, A., & Gershwin, M. E. (2016). Zika virus and neurologic autoimmunity: The putative role of gangliosides. BMC Medicine, 14(1), [49]. https://doi.org/10.1186/s12916-016-0601-y

Zika virus and neurologic autoimmunity : The putative role of gangliosides. / Anaya, Juan Manuel; Ramirez-Santana, Carolina; Salgado-Castaneda, Ignacio; Chang, Christopher; Ansari, Aftab; Gershwin, M. Eric.

In: BMC Medicine, Vol. 14, No. 1, 49, 21.03.2016.

Research output: Contribution to journalArticle

Anaya, JM, Ramirez-Santana, C, Salgado-Castaneda, I, Chang, C, Ansari, A & Gershwin, ME 2016, 'Zika virus and neurologic autoimmunity: The putative role of gangliosides', BMC Medicine, vol. 14, no. 1, 49. https://doi.org/10.1186/s12916-016-0601-y
Anaya JM, Ramirez-Santana C, Salgado-Castaneda I, Chang C, Ansari A, Gershwin ME. Zika virus and neurologic autoimmunity: The putative role of gangliosides. BMC Medicine. 2016 Mar 21;14(1). 49. https://doi.org/10.1186/s12916-016-0601-y
Anaya, Juan Manuel ; Ramirez-Santana, Carolina ; Salgado-Castaneda, Ignacio ; Chang, Christopher ; Ansari, Aftab ; Gershwin, M. Eric. / Zika virus and neurologic autoimmunity : The putative role of gangliosides. In: BMC Medicine. 2016 ; Vol. 14, No. 1.
@article{8c5e67f1da6b4d55bf421c18a2cb1e95,
title = "Zika virus and neurologic autoimmunity: The putative role of gangliosides",
abstract = "An increasing number of severe neurological complications associated with Zika virus (ZIKV), chiefly Guillain-Barr{\'e} syndrome (GBS) and primary microcephaly, have led the World Health Organization to declare a global health emergency. Molecular mimicry between glycolipids and surface molecules of infectious agents explain most of the cases of GBS preceded by infection, while a direct toxicity of ZIKV on neural cells has been raised as the main mechanism by which ZIKV induces microcephaly. Gangliosides are crucial in brain development, and their expression correlates with neurogenesis, synaptogenesis, synaptic transmission, and cell proliferation. Targeting the autoimmune response to gangliosides may represent an underexploited opportunity to examine the increased incidence of neurological complications related to ZIKV infection.",
keywords = "Autoimmunity, Gangliosides, Guillain-Barr{\'e} syndrome, Microcephaly, Zika virus",
author = "Anaya, {Juan Manuel} and Carolina Ramirez-Santana and Ignacio Salgado-Castaneda and Christopher Chang and Aftab Ansari and Gershwin, {M. Eric}",
year = "2016",
month = "3",
day = "21",
doi = "10.1186/s12916-016-0601-y",
language = "English (US)",
volume = "14",
journal = "BMC Medicine",
issn = "1741-7015",
publisher = "BioMed Central",
number = "1",

}

TY - JOUR

T1 - Zika virus and neurologic autoimmunity

T2 - The putative role of gangliosides

AU - Anaya, Juan Manuel

AU - Ramirez-Santana, Carolina

AU - Salgado-Castaneda, Ignacio

AU - Chang, Christopher

AU - Ansari, Aftab

AU - Gershwin, M. Eric

PY - 2016/3/21

Y1 - 2016/3/21

N2 - An increasing number of severe neurological complications associated with Zika virus (ZIKV), chiefly Guillain-Barré syndrome (GBS) and primary microcephaly, have led the World Health Organization to declare a global health emergency. Molecular mimicry between glycolipids and surface molecules of infectious agents explain most of the cases of GBS preceded by infection, while a direct toxicity of ZIKV on neural cells has been raised as the main mechanism by which ZIKV induces microcephaly. Gangliosides are crucial in brain development, and their expression correlates with neurogenesis, synaptogenesis, synaptic transmission, and cell proliferation. Targeting the autoimmune response to gangliosides may represent an underexploited opportunity to examine the increased incidence of neurological complications related to ZIKV infection.

AB - An increasing number of severe neurological complications associated with Zika virus (ZIKV), chiefly Guillain-Barré syndrome (GBS) and primary microcephaly, have led the World Health Organization to declare a global health emergency. Molecular mimicry between glycolipids and surface molecules of infectious agents explain most of the cases of GBS preceded by infection, while a direct toxicity of ZIKV on neural cells has been raised as the main mechanism by which ZIKV induces microcephaly. Gangliosides are crucial in brain development, and their expression correlates with neurogenesis, synaptogenesis, synaptic transmission, and cell proliferation. Targeting the autoimmune response to gangliosides may represent an underexploited opportunity to examine the increased incidence of neurological complications related to ZIKV infection.

KW - Autoimmunity

KW - Gangliosides

KW - Guillain-Barré syndrome

KW - Microcephaly

KW - Zika virus

UR - http://www.scopus.com/inward/record.url?scp=84962091501&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84962091501&partnerID=8YFLogxK

U2 - 10.1186/s12916-016-0601-y

DO - 10.1186/s12916-016-0601-y

M3 - Article

VL - 14

JO - BMC Medicine

JF - BMC Medicine

SN - 1741-7015

IS - 1

M1 - 49

ER -