Zfp488 promotes oligodendrocyte differentiation of neural progenitor cells in adult mice after demyelination

Mangala M. Soundarapandian, Vimal Selvaraj, U. Ging Lo, Mari S. Golub, Daniel H. Feldman, David E Pleasure, Wenbin Deng

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Basic helix-loop-helix transcription factors Olig1 and Olig2 critically regulate oligodendrocyte development. Initially identified as a downstream effector of Olig1, an oligodendrocyte-specific zinc finger transcription repressor, Zfp488, cooperates with Olig2 function. Although Zfp488 is required for oligodendrocyte precursor formation and differentiation during embryonic development, its role in oligodendrogenesis of adult neural progenitor cells is not known. In this study, we tested whether Zfp488 could promote an oligodendrogenic fate in adult subventricular zone (SVZ) neural stem/progenitor cells (NSPCs). Using a cuprizone-induced demyelination model in mice, we examined the effect of retrovirus-mediated Zfp488 overexpression in SVZ NSPCs. Our results showed that Zfp488 efficiently promoted the differentiation of the SVZ NSPCs into mature oligodendrocytes in vivo. After cuprizone-induced demyelination injury, Zfp488-transduced mice also showed significant restoration of motor function to levels comparable to control mice. Together, these findings identify a previously unreported role for Zfp488 in adult oligodendrogenesis and functional remyelination after injury.

Original languageEnglish (US)
Article number2
JournalScientific Reports
Volume1
DOIs
StatePublished - 2011

Fingerprint

Oligodendroglia
Demyelinating Diseases
Neural Stem Cells
Lateral Ventricles
Cuprizone
Stem Cells
Basic Helix-Loop-Helix Transcription Factors
Zinc Fingers
Wounds and Injuries
Retroviridae
Embryonic Development

ASJC Scopus subject areas

  • General

Cite this

Zfp488 promotes oligodendrocyte differentiation of neural progenitor cells in adult mice after demyelination. / Soundarapandian, Mangala M.; Selvaraj, Vimal; Lo, U. Ging; Golub, Mari S.; Feldman, Daniel H.; Pleasure, David E; Deng, Wenbin.

In: Scientific Reports, Vol. 1, 2, 2011.

Research output: Contribution to journalArticle

Soundarapandian, Mangala M. ; Selvaraj, Vimal ; Lo, U. Ging ; Golub, Mari S. ; Feldman, Daniel H. ; Pleasure, David E ; Deng, Wenbin. / Zfp488 promotes oligodendrocyte differentiation of neural progenitor cells in adult mice after demyelination. In: Scientific Reports. 2011 ; Vol. 1.
@article{74d5a01e24d741b8b76774effa75c1c7,
title = "Zfp488 promotes oligodendrocyte differentiation of neural progenitor cells in adult mice after demyelination",
abstract = "Basic helix-loop-helix transcription factors Olig1 and Olig2 critically regulate oligodendrocyte development. Initially identified as a downstream effector of Olig1, an oligodendrocyte-specific zinc finger transcription repressor, Zfp488, cooperates with Olig2 function. Although Zfp488 is required for oligodendrocyte precursor formation and differentiation during embryonic development, its role in oligodendrogenesis of adult neural progenitor cells is not known. In this study, we tested whether Zfp488 could promote an oligodendrogenic fate in adult subventricular zone (SVZ) neural stem/progenitor cells (NSPCs). Using a cuprizone-induced demyelination model in mice, we examined the effect of retrovirus-mediated Zfp488 overexpression in SVZ NSPCs. Our results showed that Zfp488 efficiently promoted the differentiation of the SVZ NSPCs into mature oligodendrocytes in vivo. After cuprizone-induced demyelination injury, Zfp488-transduced mice also showed significant restoration of motor function to levels comparable to control mice. Together, these findings identify a previously unreported role for Zfp488 in adult oligodendrogenesis and functional remyelination after injury.",
author = "Soundarapandian, {Mangala M.} and Vimal Selvaraj and Lo, {U. Ging} and Golub, {Mari S.} and Feldman, {Daniel H.} and Pleasure, {David E} and Wenbin Deng",
year = "2011",
doi = "10.1038/srep00002",
language = "English (US)",
volume = "1",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",

}

TY - JOUR

T1 - Zfp488 promotes oligodendrocyte differentiation of neural progenitor cells in adult mice after demyelination

AU - Soundarapandian, Mangala M.

AU - Selvaraj, Vimal

AU - Lo, U. Ging

AU - Golub, Mari S.

AU - Feldman, Daniel H.

AU - Pleasure, David E

AU - Deng, Wenbin

PY - 2011

Y1 - 2011

N2 - Basic helix-loop-helix transcription factors Olig1 and Olig2 critically regulate oligodendrocyte development. Initially identified as a downstream effector of Olig1, an oligodendrocyte-specific zinc finger transcription repressor, Zfp488, cooperates with Olig2 function. Although Zfp488 is required for oligodendrocyte precursor formation and differentiation during embryonic development, its role in oligodendrogenesis of adult neural progenitor cells is not known. In this study, we tested whether Zfp488 could promote an oligodendrogenic fate in adult subventricular zone (SVZ) neural stem/progenitor cells (NSPCs). Using a cuprizone-induced demyelination model in mice, we examined the effect of retrovirus-mediated Zfp488 overexpression in SVZ NSPCs. Our results showed that Zfp488 efficiently promoted the differentiation of the SVZ NSPCs into mature oligodendrocytes in vivo. After cuprizone-induced demyelination injury, Zfp488-transduced mice also showed significant restoration of motor function to levels comparable to control mice. Together, these findings identify a previously unreported role for Zfp488 in adult oligodendrogenesis and functional remyelination after injury.

AB - Basic helix-loop-helix transcription factors Olig1 and Olig2 critically regulate oligodendrocyte development. Initially identified as a downstream effector of Olig1, an oligodendrocyte-specific zinc finger transcription repressor, Zfp488, cooperates with Olig2 function. Although Zfp488 is required for oligodendrocyte precursor formation and differentiation during embryonic development, its role in oligodendrogenesis of adult neural progenitor cells is not known. In this study, we tested whether Zfp488 could promote an oligodendrogenic fate in adult subventricular zone (SVZ) neural stem/progenitor cells (NSPCs). Using a cuprizone-induced demyelination model in mice, we examined the effect of retrovirus-mediated Zfp488 overexpression in SVZ NSPCs. Our results showed that Zfp488 efficiently promoted the differentiation of the SVZ NSPCs into mature oligodendrocytes in vivo. After cuprizone-induced demyelination injury, Zfp488-transduced mice also showed significant restoration of motor function to levels comparable to control mice. Together, these findings identify a previously unreported role for Zfp488 in adult oligodendrogenesis and functional remyelination after injury.

UR - http://www.scopus.com/inward/record.url?scp=84860154744&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84860154744&partnerID=8YFLogxK

U2 - 10.1038/srep00002

DO - 10.1038/srep00002

M3 - Article

C2 - 22355521

AN - SCOPUS:84860154744

VL - 1

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

M1 - 2

ER -