You've got to be kindlin!

Scott I. Simon

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

In this issue of Blood, Liao et al report that kindlin-2 is necessary for angiogenic sprouting in vitro and for developmental and tumor angiogenesis in vivo.1 The process of blood vessel sprouting is known to involve the αVβ3 vitronectin integrin on endothelium. Kindlin-2 linkage to the C-terminal tail of β3 completed the outside-in circuit necessary for integrin signaling that is critical for navigation of new vessel sprouts.

Original languageEnglish (US)
Pages (from-to)1855-1856
Number of pages2
JournalBlood
Volume125
Issue number12
DOIs
StatePublished - Mar 19 2015

Fingerprint

Integrins
Vitronectin
Blood vessels
Endothelium
Blood Vessels
Tumors
Navigation
Blood
Networks (circuits)
Neoplasms
In Vitro Techniques

ASJC Scopus subject areas

  • Hematology
  • Biochemistry
  • Cell Biology
  • Immunology

Cite this

You've got to be kindlin! / Simon, Scott I.

In: Blood, Vol. 125, No. 12, 19.03.2015, p. 1855-1856.

Research output: Contribution to journalArticle

Simon, SI 2015, 'You've got to be kindlin!', Blood, vol. 125, no. 12, pp. 1855-1856. https://doi.org/10.1182/blood-2015-02-623843
Simon, Scott I. / You've got to be kindlin!. In: Blood. 2015 ; Vol. 125, No. 12. pp. 1855-1856.
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