Younger pubertal age is associated with allergy and other atopic conditions in girls

Chi Chen Hong, Ashley Pajak, Susan L. Teitelbaum, Nita Vangeepuram, Maida Galvez, Susan M. Pinney, Gayle Windham, Lawrence H. Kushi, Frank M. Biro, Mary S. Wolff

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: Early menarche is linked to higher incidence of adult asthma, suggesting that earlier puberty may influence type 2 immune response characteristics of allergic diseases. We examined the hypothesis that timing of breast and pubic hair development, which precede menarche, is associated with increased childhood atopic conditions. Methods: Girls were enrolled at 6-8 yr of age (2004-2007) in the Breast Cancer and the Environment Research Program Puberty Study and were followed through 2011. Pubertal stages were assessed and atopic conditions were queried annually. Associations of age at pubertal stage 2 for breast or pubic hair development with atopic conditions were assessed using prevalence ratios (PR) or odds ratios (OR) and 95% confidence intervals (CI) from log-binomial regression and generalized estimating equation models, controlling for body mass index and other covariates. A total of 1055 girls with medical and pubertal stage data were included. Results: Asthma (ever vs. never) was associated with younger pubarche (≤10 vs. >10 yr, PR = 1.15, CI: 1.04-1.28 adjusted for race/ethnicity and site; PR = 1.13, CI: 1.01-1.25 further adjusted for BMI), but not thelarche. In longitudinal models, risk of developing allergies increased with younger age at pubarche (adjusted OR = 1.60, CI: 1.10-2.34; ≤10 vs. >10 yr). Risks were highest among black girls with earlier pubarche (n = 248/326); for allergies, their fully adjusted OR was 2.35, CI: 1.06-5.19 for pubarche ≤10 vs. >10 yr. Conclusions: Atopic conditions during childhood are associated with younger age at pubarche, independent of obesity, and these relationships may vary by racial/ethnic groups.

Original languageEnglish (US)
Pages (from-to)773-780
Number of pages8
JournalPediatric Allergy and Immunology
Volume25
Issue number8
DOIs
StatePublished - Dec 1 2014
Externally publishedYes

Fingerprint

Hypersensitivity
Confidence Intervals
Menarche
Odds Ratio
Puberty
Hair
Breast
Asthma
Ethnic Groups
Body Mass Index
Obesity
Breast Neoplasms
Incidence
Research

Keywords

  • Allergies
  • Asthma
  • Breast development
  • Early puberty
  • Girls
  • Pubic hair development

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pediatrics, Perinatology, and Child Health
  • Immunology

Cite this

Hong, C. C., Pajak, A., Teitelbaum, S. L., Vangeepuram, N., Galvez, M., Pinney, S. M., ... Wolff, M. S. (2014). Younger pubertal age is associated with allergy and other atopic conditions in girls. Pediatric Allergy and Immunology, 25(8), 773-780. https://doi.org/10.1111/pai.12307

Younger pubertal age is associated with allergy and other atopic conditions in girls. / Hong, Chi Chen; Pajak, Ashley; Teitelbaum, Susan L.; Vangeepuram, Nita; Galvez, Maida; Pinney, Susan M.; Windham, Gayle; Kushi, Lawrence H.; Biro, Frank M.; Wolff, Mary S.

In: Pediatric Allergy and Immunology, Vol. 25, No. 8, 01.12.2014, p. 773-780.

Research output: Contribution to journalArticle

Hong, CC, Pajak, A, Teitelbaum, SL, Vangeepuram, N, Galvez, M, Pinney, SM, Windham, G, Kushi, LH, Biro, FM & Wolff, MS 2014, 'Younger pubertal age is associated with allergy and other atopic conditions in girls', Pediatric Allergy and Immunology, vol. 25, no. 8, pp. 773-780. https://doi.org/10.1111/pai.12307
Hong CC, Pajak A, Teitelbaum SL, Vangeepuram N, Galvez M, Pinney SM et al. Younger pubertal age is associated with allergy and other atopic conditions in girls. Pediatric Allergy and Immunology. 2014 Dec 1;25(8):773-780. https://doi.org/10.1111/pai.12307
Hong, Chi Chen ; Pajak, Ashley ; Teitelbaum, Susan L. ; Vangeepuram, Nita ; Galvez, Maida ; Pinney, Susan M. ; Windham, Gayle ; Kushi, Lawrence H. ; Biro, Frank M. ; Wolff, Mary S. / Younger pubertal age is associated with allergy and other atopic conditions in girls. In: Pediatric Allergy and Immunology. 2014 ; Vol. 25, No. 8. pp. 773-780.
@article{3ec907b462d045eab4654ec91bf3d8d5,
title = "Younger pubertal age is associated with allergy and other atopic conditions in girls",
abstract = "Background: Early menarche is linked to higher incidence of adult asthma, suggesting that earlier puberty may influence type 2 immune response characteristics of allergic diseases. We examined the hypothesis that timing of breast and pubic hair development, which precede menarche, is associated with increased childhood atopic conditions. Methods: Girls were enrolled at 6-8 yr of age (2004-2007) in the Breast Cancer and the Environment Research Program Puberty Study and were followed through 2011. Pubertal stages were assessed and atopic conditions were queried annually. Associations of age at pubertal stage 2 for breast or pubic hair development with atopic conditions were assessed using prevalence ratios (PR) or odds ratios (OR) and 95{\%} confidence intervals (CI) from log-binomial regression and generalized estimating equation models, controlling for body mass index and other covariates. A total of 1055 girls with medical and pubertal stage data were included. Results: Asthma (ever vs. never) was associated with younger pubarche (≤10 vs. >10 yr, PR = 1.15, CI: 1.04-1.28 adjusted for race/ethnicity and site; PR = 1.13, CI: 1.01-1.25 further adjusted for BMI), but not thelarche. In longitudinal models, risk of developing allergies increased with younger age at pubarche (adjusted OR = 1.60, CI: 1.10-2.34; ≤10 vs. >10 yr). Risks were highest among black girls with earlier pubarche (n = 248/326); for allergies, their fully adjusted OR was 2.35, CI: 1.06-5.19 for pubarche ≤10 vs. >10 yr. Conclusions: Atopic conditions during childhood are associated with younger age at pubarche, independent of obesity, and these relationships may vary by racial/ethnic groups.",
keywords = "Allergies, Asthma, Breast development, Early puberty, Girls, Pubic hair development",
author = "Hong, {Chi Chen} and Ashley Pajak and Teitelbaum, {Susan L.} and Nita Vangeepuram and Maida Galvez and Pinney, {Susan M.} and Gayle Windham and Kushi, {Lawrence H.} and Biro, {Frank M.} and Wolff, {Mary S.}",
year = "2014",
month = "12",
day = "1",
doi = "10.1111/pai.12307",
language = "English (US)",
volume = "25",
pages = "773--780",
journal = "Pediatric Allergy and Immunology",
issn = "0905-6157",
publisher = "Blackwell Munksgaard",
number = "8",

}

TY - JOUR

T1 - Younger pubertal age is associated with allergy and other atopic conditions in girls

AU - Hong, Chi Chen

AU - Pajak, Ashley

AU - Teitelbaum, Susan L.

AU - Vangeepuram, Nita

AU - Galvez, Maida

AU - Pinney, Susan M.

AU - Windham, Gayle

AU - Kushi, Lawrence H.

AU - Biro, Frank M.

AU - Wolff, Mary S.

PY - 2014/12/1

Y1 - 2014/12/1

N2 - Background: Early menarche is linked to higher incidence of adult asthma, suggesting that earlier puberty may influence type 2 immune response characteristics of allergic diseases. We examined the hypothesis that timing of breast and pubic hair development, which precede menarche, is associated with increased childhood atopic conditions. Methods: Girls were enrolled at 6-8 yr of age (2004-2007) in the Breast Cancer and the Environment Research Program Puberty Study and were followed through 2011. Pubertal stages were assessed and atopic conditions were queried annually. Associations of age at pubertal stage 2 for breast or pubic hair development with atopic conditions were assessed using prevalence ratios (PR) or odds ratios (OR) and 95% confidence intervals (CI) from log-binomial regression and generalized estimating equation models, controlling for body mass index and other covariates. A total of 1055 girls with medical and pubertal stage data were included. Results: Asthma (ever vs. never) was associated with younger pubarche (≤10 vs. >10 yr, PR = 1.15, CI: 1.04-1.28 adjusted for race/ethnicity and site; PR = 1.13, CI: 1.01-1.25 further adjusted for BMI), but not thelarche. In longitudinal models, risk of developing allergies increased with younger age at pubarche (adjusted OR = 1.60, CI: 1.10-2.34; ≤10 vs. >10 yr). Risks were highest among black girls with earlier pubarche (n = 248/326); for allergies, their fully adjusted OR was 2.35, CI: 1.06-5.19 for pubarche ≤10 vs. >10 yr. Conclusions: Atopic conditions during childhood are associated with younger age at pubarche, independent of obesity, and these relationships may vary by racial/ethnic groups.

AB - Background: Early menarche is linked to higher incidence of adult asthma, suggesting that earlier puberty may influence type 2 immune response characteristics of allergic diseases. We examined the hypothesis that timing of breast and pubic hair development, which precede menarche, is associated with increased childhood atopic conditions. Methods: Girls were enrolled at 6-8 yr of age (2004-2007) in the Breast Cancer and the Environment Research Program Puberty Study and were followed through 2011. Pubertal stages were assessed and atopic conditions were queried annually. Associations of age at pubertal stage 2 for breast or pubic hair development with atopic conditions were assessed using prevalence ratios (PR) or odds ratios (OR) and 95% confidence intervals (CI) from log-binomial regression and generalized estimating equation models, controlling for body mass index and other covariates. A total of 1055 girls with medical and pubertal stage data were included. Results: Asthma (ever vs. never) was associated with younger pubarche (≤10 vs. >10 yr, PR = 1.15, CI: 1.04-1.28 adjusted for race/ethnicity and site; PR = 1.13, CI: 1.01-1.25 further adjusted for BMI), but not thelarche. In longitudinal models, risk of developing allergies increased with younger age at pubarche (adjusted OR = 1.60, CI: 1.10-2.34; ≤10 vs. >10 yr). Risks were highest among black girls with earlier pubarche (n = 248/326); for allergies, their fully adjusted OR was 2.35, CI: 1.06-5.19 for pubarche ≤10 vs. >10 yr. Conclusions: Atopic conditions during childhood are associated with younger age at pubarche, independent of obesity, and these relationships may vary by racial/ethnic groups.

KW - Allergies

KW - Asthma

KW - Breast development

KW - Early puberty

KW - Girls

KW - Pubic hair development

UR - http://www.scopus.com/inward/record.url?scp=84922503738&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84922503738&partnerID=8YFLogxK

U2 - 10.1111/pai.12307

DO - 10.1111/pai.12307

M3 - Article

C2 - 25387609

AN - SCOPUS:84922503738

VL - 25

SP - 773

EP - 780

JO - Pediatric Allergy and Immunology

JF - Pediatric Allergy and Immunology

SN - 0905-6157

IS - 8

ER -