Abstract
Understanding how cell growth is regulated in response to environmental signals remains a challenging biological problem. Recent studies indicate the TOR (target of rapamycin) kinase acts within an intracellular regulatory network used by eukaryotic cells to regulate their growth according to nutrient availability. This network affects all aspects of gene expression, including transcription, translation, and protein stability, making TOR an excellent candidate as a global regulator of cellular activity. Here we review our recent studies of two specific transcriptional outputs controlled by TOR in the budding yeast, S. cerevisiae: (1) positive regulation of genes involved in ribosome biogenesis, and (2) negative regulation of genes required for de novo biosynthesis of glutamate and glutamine. These studies have raised the important issue as to how diverse nutritional cues can pass through a common signaling pathway and yet ultimately generate distinct transcriptional responses.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 39-51 |
| Number of pages | 13 |
| Journal | Current Topics in Microbiology and Immunology |
| Volume | 279 |
| State | Published - 2003 |
Fingerprint
ASJC Scopus subject areas
- Immunology and Allergy
- Microbiology (medical)
- Immunology and Microbiology(all)
- Microbiology
Cite this
Yeast TOR signaling : A mechanism for metabolic regulation. / Powers, T.; Dilova, I.; Chen, C. Y.; Wedaman, K.
In: Current Topics in Microbiology and Immunology, Vol. 279, 2003, p. 39-51.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Yeast TOR signaling
T2 - A mechanism for metabolic regulation
AU - Powers, T.
AU - Dilova, I.
AU - Chen, C. Y.
AU - Wedaman, K.
PY - 2003
Y1 - 2003
N2 - Understanding how cell growth is regulated in response to environmental signals remains a challenging biological problem. Recent studies indicate the TOR (target of rapamycin) kinase acts within an intracellular regulatory network used by eukaryotic cells to regulate their growth according to nutrient availability. This network affects all aspects of gene expression, including transcription, translation, and protein stability, making TOR an excellent candidate as a global regulator of cellular activity. Here we review our recent studies of two specific transcriptional outputs controlled by TOR in the budding yeast, S. cerevisiae: (1) positive regulation of genes involved in ribosome biogenesis, and (2) negative regulation of genes required for de novo biosynthesis of glutamate and glutamine. These studies have raised the important issue as to how diverse nutritional cues can pass through a common signaling pathway and yet ultimately generate distinct transcriptional responses.
AB - Understanding how cell growth is regulated in response to environmental signals remains a challenging biological problem. Recent studies indicate the TOR (target of rapamycin) kinase acts within an intracellular regulatory network used by eukaryotic cells to regulate their growth according to nutrient availability. This network affects all aspects of gene expression, including transcription, translation, and protein stability, making TOR an excellent candidate as a global regulator of cellular activity. Here we review our recent studies of two specific transcriptional outputs controlled by TOR in the budding yeast, S. cerevisiae: (1) positive regulation of genes involved in ribosome biogenesis, and (2) negative regulation of genes required for de novo biosynthesis of glutamate and glutamine. These studies have raised the important issue as to how diverse nutritional cues can pass through a common signaling pathway and yet ultimately generate distinct transcriptional responses.
UR - http://www.scopus.com/inward/record.url?scp=0042823575&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0042823575&partnerID=8YFLogxK
M3 - Article
C2 - 14560950
AN - SCOPUS:0042823575
VL - 279
SP - 39
EP - 51
JO - Current Topics in Microbiology and Immunology
JF - Current Topics in Microbiology and Immunology
SN - 0070-217X
ER -