Yeast signaling pathways in the oxidative stress response

Aminah Ikner, Kazuhiro Shiozaki

Research output: Contribution to journalArticlepeer-review

175 Scopus citations


Oxidative stress that generates the reactive oxygen species (ROS) is one of the major causes of DNA damage and mutations. The "DNA damage checkpoint" that arrests cell cycle and repairs damaged DNA has been a focus of recent studies, and the genetically amenable model systems provided by yeasts have been playing a leading role in the eukaryotic checkpoint research. However, means to eliminate ROS are likely to be as important as the DNA repair mechanisms in order to suppress mutations in the chromosomal DNA, and yeasts also serve as excellent models to understand how eukaryotes combat oxidative stress. In this article, we present an overview of the signaling pathways that sense oxidative stress and induce expression of various anti-oxidant genes in the budding yeast Saccharomyces cerevisiae, the fission yeast Schizosaccharomyces pombe and the pathogenic yeast Candida albicans. Three conserved signaling modules have been identified in the oxidative stress response of these diverse yeast species: the stress-responsive MAP kinase cascade, the multistep phosphorelay and the AP-1-like transcription factor. The structure and function of these signaling modules are discussed.

Original languageEnglish (US)
Pages (from-to)13-27
Number of pages15
JournalMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Issue number1-2
StatePublished - Jan 6 2005


  • DNA
  • Oxidative stress
  • Reactive oxygen species (ROS)
  • Stress-activated protein kinases (SAPK)
  • Yeast

ASJC Scopus subject areas

  • Health, Toxicology and Mutagenesis
  • Molecular Biology


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