YCL047C/POF1 is a novel nicotinamide mononucleotide adenylyltransferase (NMNAT) in Saccharomyces cerevisiae

Michiko Kato, Su Ju Lin

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Background: Factors regulating NAD+ metabolism and homeostasis remain unclear because of the dynamic nature of NAD+ synthesis pathways. Results: Pof1 is a novel NMN-specific NMNAT that mediates NAD + production. Conclusion: Enzymes with redundant function may provide flexibility to maintain NAD+ homeostasis. Significance: Novel NAD+ metabolic factors are identified, aiding our understanding of the complex NAD+ pathways.

Original languageEnglish (US)
Pages (from-to)15577-15587
Number of pages11
JournalJournal of Biological Chemistry
Volume289
Issue number22
DOIs
StatePublished - May 30 2014

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

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