Primarna bilijarna ciroza indukovana ksenobiotikom: Eksperimentalni model

Translated title of the contribution: Xenobiotic induced model of primary biliary cirrhosis

Aleksandar Arsenijevic, Jelena Milovanovic, Bojana Stojanovic, Marija Milovanovic, M. Eric Gershwin, Patrick S Leung, Nebojsa Arsenijevic, Miodrag L. Lukic

Research output: Contribution to journalArticle

Abstract

Primary biliary cirrhosis (PBC) is an autoimmune disease of the liver that is, characterised by destruction of the intrahepatic bile ducts and the presence of antimitochondrial antibodies (AMAs). Several murine models of PBC, with similar serological, biochemical, and histological features to human PBC, have been developed in recent years. These animal models enable investigators to study the etiology and pathophysiologic mechanism of PBC. Immune response in PBC is directed towards E2 components of the 2-oxo-acid dehydrogenase family of enzymes, which is in located in mitochondria and is an immunodominant epitope (a lipoylated peptide sequence shared by enzymes). Immunisation of mice with 2-octynoic acid coupled to bovine serum albumin (2-OA-BSA) (which is an antigen that is structurally related to the E2 subunit of the pyruvate dehydrogenase complex [PDC-E2]) produces histologic features similar to those found in human PBC. Th is model of xenobiotic induced PBC is suitable for studying the early events in PBC pathogenesis and for developing new therapeutics in PBC.

Original languageUndefined/Unknown
Pages (from-to)145-150
Number of pages6
JournalSerbian Journal of Experimental and Clinical Research
Volume15
Issue number3
DOIs
StatePublished - Oct 3 2014

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Biliary Liver Cirrhosis
Xenobiotics
Dihydrolipoyllysine-Residue Acetyltransferase
Keto Acids
Intrahepatic Bile Ducts
Immunodominant Epitopes
Enzymes
Bovine Serum Albumin
Autoimmune Diseases
Immunization
Mitochondria
Oxidoreductases
Animal Models
Research Personnel
Antigens
Peptides
Antibodies
Liver

Keywords

  • 2OA-BSA
  • C57BL/6 mice
  • PBC
  • Xenobiotic

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Primarna bilijarna ciroza indukovana ksenobiotikom : Eksperimentalni model. / Arsenijevic, Aleksandar; Milovanovic, Jelena; Stojanovic, Bojana; Milovanovic, Marija; Gershwin, M. Eric; Leung, Patrick S; Arsenijevic, Nebojsa; Lukic, Miodrag L.

In: Serbian Journal of Experimental and Clinical Research, Vol. 15, No. 3, 03.10.2014, p. 145-150.

Research output: Contribution to journalArticle

Arsenijevic, A, Milovanovic, J, Stojanovic, B, Milovanovic, M, Gershwin, ME, Leung, PS, Arsenijevic, N & Lukic, ML 2014, 'Primarna bilijarna ciroza indukovana ksenobiotikom: Eksperimentalni model', Serbian Journal of Experimental and Clinical Research, vol. 15, no. 3, pp. 145-150. https://doi.org/10.2478/SJECR-2014-0019
Arsenijevic, Aleksandar ; Milovanovic, Jelena ; Stojanovic, Bojana ; Milovanovic, Marija ; Gershwin, M. Eric ; Leung, Patrick S ; Arsenijevic, Nebojsa ; Lukic, Miodrag L. / Primarna bilijarna ciroza indukovana ksenobiotikom : Eksperimentalni model. In: Serbian Journal of Experimental and Clinical Research. 2014 ; Vol. 15, No. 3. pp. 145-150.
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