Abstract
Primary biliary cirrhosis (PBC) is an autoimmune disease of the liver that is, characterised by destruction of the intrahepatic bile ducts and the presence of antimitochondrial antibodies (AMAs). Several murine models of PBC, with similar serological, biochemical, and histological features to human PBC, have been developed in recent years. These animal models enable investigators to study the etiology and pathophysiologic mechanism of PBC. Immune response in PBC is directed towards E2 components of the 2-oxo-acid dehydrogenase family of enzymes, which is in located in mitochondria and is an immunodominant epitope (a lipoylated peptide sequence shared by enzymes). Immunisation of mice with 2-octynoic acid coupled to bovine serum albumin (2-OA-BSA) (which is an antigen that is structurally related to the E2 subunit of the pyruvate dehydrogenase complex [PDC-E2]) produces histologic features similar to those found in human PBC. Th is model of xenobiotic induced PBC is suitable for studying the early events in PBC pathogenesis and for developing new therapeutics in PBC.
| Original language | Undefined/Unknown |
|---|---|
| Pages (from-to) | 145-150 |
| Number of pages | 6 |
| Journal | Serbian Journal of Experimental and Clinical Research |
| Volume | 15 |
| Issue number | 3 |
| DOIs | |
| State | Published - Oct 3 2014 |
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Keywords
- 2OA-BSA
- C57BL/6 mice
- PBC
- Xenobiotic
ASJC Scopus subject areas
- Medicine(all)
Cite this
Primarna bilijarna ciroza indukovana ksenobiotikom : Eksperimentalni model. / Arsenijevic, Aleksandar; Milovanovic, Jelena; Stojanovic, Bojana; Milovanovic, Marija; Gershwin, M. Eric; Leung, Patrick S; Arsenijevic, Nebojsa; Lukic, Miodrag L.
In: Serbian Journal of Experimental and Clinical Research, Vol. 15, No. 3, 03.10.2014, p. 145-150.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Primarna bilijarna ciroza indukovana ksenobiotikom
T2 - Eksperimentalni model
AU - Arsenijevic, Aleksandar
AU - Milovanovic, Jelena
AU - Stojanovic, Bojana
AU - Milovanovic, Marija
AU - Gershwin, M. Eric
AU - Leung, Patrick S
AU - Arsenijevic, Nebojsa
AU - Lukic, Miodrag L.
PY - 2014/10/3
Y1 - 2014/10/3
N2 - Primary biliary cirrhosis (PBC) is an autoimmune disease of the liver that is, characterised by destruction of the intrahepatic bile ducts and the presence of antimitochondrial antibodies (AMAs). Several murine models of PBC, with similar serological, biochemical, and histological features to human PBC, have been developed in recent years. These animal models enable investigators to study the etiology and pathophysiologic mechanism of PBC. Immune response in PBC is directed towards E2 components of the 2-oxo-acid dehydrogenase family of enzymes, which is in located in mitochondria and is an immunodominant epitope (a lipoylated peptide sequence shared by enzymes). Immunisation of mice with 2-octynoic acid coupled to bovine serum albumin (2-OA-BSA) (which is an antigen that is structurally related to the E2 subunit of the pyruvate dehydrogenase complex [PDC-E2]) produces histologic features similar to those found in human PBC. Th is model of xenobiotic induced PBC is suitable for studying the early events in PBC pathogenesis and for developing new therapeutics in PBC.
AB - Primary biliary cirrhosis (PBC) is an autoimmune disease of the liver that is, characterised by destruction of the intrahepatic bile ducts and the presence of antimitochondrial antibodies (AMAs). Several murine models of PBC, with similar serological, biochemical, and histological features to human PBC, have been developed in recent years. These animal models enable investigators to study the etiology and pathophysiologic mechanism of PBC. Immune response in PBC is directed towards E2 components of the 2-oxo-acid dehydrogenase family of enzymes, which is in located in mitochondria and is an immunodominant epitope (a lipoylated peptide sequence shared by enzymes). Immunisation of mice with 2-octynoic acid coupled to bovine serum albumin (2-OA-BSA) (which is an antigen that is structurally related to the E2 subunit of the pyruvate dehydrogenase complex [PDC-E2]) produces histologic features similar to those found in human PBC. Th is model of xenobiotic induced PBC is suitable for studying the early events in PBC pathogenesis and for developing new therapeutics in PBC.
KW - 2OA-BSA
KW - C57BL/6 mice
KW - PBC
KW - Xenobiotic
UR - http://www.scopus.com/inward/record.url?scp=84919789672&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84919789672&partnerID=8YFLogxK
U2 - 10.2478/SJECR-2014-0019
DO - 10.2478/SJECR-2014-0019
M3 - Article
AN - SCOPUS:84919789672
VL - 15
SP - 145
EP - 150
JO - Serbian Journal of Experimental and Clinical Research
JF - Serbian Journal of Experimental and Clinical Research
SN - 1820-8665
IS - 3
ER -