X-ray-Mediated Release of Molecules and Engineered Proteins from Nanostructure Surfaces

Mengqi Su, Kathryn G. Guggenheim, Jennifer Lien, Justin Siegel, Ting Guo

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Many applications call for initiation of chemical reactions with highly penetrating X-rays with nanometer precision and little damage to the surroundings, which is difficult to realize because of low interaction cross-sections between hard X-rays and organic matters. Here, we demonstrate that a combination of computational protein design of single conjugation site green fluorescent proteins and nanomaterial engineering of silica-covered gold nanoparticles can enhance the release efficiencies of proteins from the surface of nanoparticles. The nanoparticles, to which the proteins are attached through DNA linkers, provide increased X-ray absorption without scavenging radicals, and single conjugation sites allow efficient release of proteins.

Original languageEnglish (US)
Pages (from-to)31860-31864
Number of pages5
JournalACS Applied Materials and Interfaces
Issue number38
StatePublished - Sep 26 2018


  • DNA strand breaks
  • engineered proteins
  • enhanced release
  • gold nanoparticles
  • silica coating
  • surface functionalized nanoparticles
  • X-ray mediated reactions
  • X-ray triggered release

ASJC Scopus subject areas

  • Materials Science(all)


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