Abstract
We present a hybrid imaging modality, x-ray luminescence optical tomography (XLOT), in which collimated x-ray beams are used to excite phosphor-based contrast agents. Images are reconstructed from the optical signals, using the known x-ray beam location and spatial extent aspriors. We demonstrate XLOT using phantom experiments with deep targets and show that the reconstructed signal varies by <12% when the depth changes from 4.2 to 7.7 mm. For simple source distributions, we find as few as two orthogonal projection measurements are sufficient for XLOT reconstruction.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2339-2341 |
| Number of pages | 3 |
| Journal | Optics Letters |
| Volume | 38 |
| Issue number | 13 |
| DOIs | |
| State | Published - Jul 1 2013 |
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ASJC Scopus subject areas
- Atomic and Molecular Physics, and Optics
- Medicine(all)
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X-ray luminescence optical tomography imaging experimental studies. / Li, Changqing; Di, Kun; Bec, Julien; Cherry, Simon R.
In: Optics Letters, Vol. 38, No. 13, 01.07.2013, p. 2339-2341.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - X-ray luminescence optical tomography imaging experimental studies
AU - Li, Changqing
AU - Di, Kun
AU - Bec, Julien
AU - Cherry, Simon R
PY - 2013/7/1
Y1 - 2013/7/1
N2 - We present a hybrid imaging modality, x-ray luminescence optical tomography (XLOT), in which collimated x-ray beams are used to excite phosphor-based contrast agents. Images are reconstructed from the optical signals, using the known x-ray beam location and spatial extent aspriors. We demonstrate XLOT using phantom experiments with deep targets and show that the reconstructed signal varies by <12% when the depth changes from 4.2 to 7.7 mm. For simple source distributions, we find as few as two orthogonal projection measurements are sufficient for XLOT reconstruction.
AB - We present a hybrid imaging modality, x-ray luminescence optical tomography (XLOT), in which collimated x-ray beams are used to excite phosphor-based contrast agents. Images are reconstructed from the optical signals, using the known x-ray beam location and spatial extent aspriors. We demonstrate XLOT using phantom experiments with deep targets and show that the reconstructed signal varies by <12% when the depth changes from 4.2 to 7.7 mm. For simple source distributions, we find as few as two orthogonal projection measurements are sufficient for XLOT reconstruction.
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UR - http://www.scopus.com/inward/citedby.url?scp=84879648462&partnerID=8YFLogxK
U2 - 10.1364/OL.38.002339
DO - 10.1364/OL.38.002339
M3 - Article
C2 - 23811921
AN - SCOPUS:84879648462
VL - 38
SP - 2339
EP - 2341
JO - Optics Letters
JF - Optics Letters
SN - 0146-9592
IS - 13
ER -