Abstract
In this paper we discuss the potential for application of x-ray holographic imaging techniques to the sequencing of DNA. We formulate an approximate model for the scattering of partially coherent x-rays from an oriented DNA fiber and show the feasibility of reconstruction of heavy atom label positions from the x-ray scattering data. A series of simulations has been done to demonstrate the required reconstruction algorithms. An x-ray experiment is currently in progress to demonstrate the real feasibility of the technique.
Original language | English (US) |
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Title of host publication | Proceedings of SPIE - The International Society for Optical Engineering |
Editors | James P. Knauer, Gopal K. Shenoy |
Publisher | Publ by Int Soc for Optical Engineering |
Pages | 255-259 |
Number of pages | 5 |
Volume | 1345 |
State | Published - 1990 |
Externally published | Yes |
Event | Advanced X-Ray/EUV Radiation Sources and Applications - San Diego, CA, USA Duration: Jul 11 1990 → Jul 13 1990 |
Other
Other | Advanced X-Ray/EUV Radiation Sources and Applications |
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City | San Diego, CA, USA |
Period | 7/11/90 → 7/13/90 |
ASJC Scopus subject areas
- Electrical and Electronic Engineering
- Condensed Matter Physics