Abstract
In this paper we discuss the potential for application of x-ray holographic imaging techniques to the sequencing of DNA. We formulate an approximate model for the scattering of partially coherent x-rays from an oriented DNA fiber and show the feasibility of reconstruction of heavy atom label positions from the x-ray scattering data. A series of simulations has been done to demonstrate the required reconstruction algorithms. An x-ray experiment is currently in progress to demonstrate the real feasibility of the technique.
| Original language | English (US) |
|---|---|
| Title of host publication | Proceedings of SPIE - The International Society for Optical Engineering |
| Editors | James P. Knauer, Gopal K. Shenoy |
| Publisher | Publ by Int Soc for Optical Engineering |
| Pages | 255-259 |
| Number of pages | 5 |
| Volume | 1345 |
| State | Published - 1990 |
| Externally published | Yes |
| Event | Advanced X-Ray/EUV Radiation Sources and Applications - San Diego, CA, USA Duration: Jul 11 1990 → Jul 13 1990 |
Other
| Other | Advanced X-Ray/EUV Radiation Sources and Applications |
|---|---|
| City | San Diego, CA, USA |
| Period | 7/11/90 → 7/13/90 |
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ASJC Scopus subject areas
- Electrical and Electronic Engineering
- Condensed Matter Physics
Cite this
X-ray holography for sequencing DNA. / Yorkey, T.; Brase, J.; Trebes, J.; Lane, S.; Gray, J.
Proceedings of SPIE - The International Society for Optical Engineering. ed. / James P. Knauer; Gopal K. Shenoy. Vol. 1345 Publ by Int Soc for Optical Engineering, 1990. p. 255-259.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - X-ray holography for sequencing DNA
AU - Yorkey, T.
AU - Brase, J.
AU - Trebes, J.
AU - Lane, S.
AU - Gray, J.
PY - 1990
Y1 - 1990
N2 - In this paper we discuss the potential for application of x-ray holographic imaging techniques to the sequencing of DNA. We formulate an approximate model for the scattering of partially coherent x-rays from an oriented DNA fiber and show the feasibility of reconstruction of heavy atom label positions from the x-ray scattering data. A series of simulations has been done to demonstrate the required reconstruction algorithms. An x-ray experiment is currently in progress to demonstrate the real feasibility of the technique.
AB - In this paper we discuss the potential for application of x-ray holographic imaging techniques to the sequencing of DNA. We formulate an approximate model for the scattering of partially coherent x-rays from an oriented DNA fiber and show the feasibility of reconstruction of heavy atom label positions from the x-ray scattering data. A series of simulations has been done to demonstrate the required reconstruction algorithms. An x-ray experiment is currently in progress to demonstrate the real feasibility of the technique.
UR - http://www.scopus.com/inward/record.url?scp=0025531468&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025531468&partnerID=8YFLogxK
M3 - Conference contribution
VL - 1345
SP - 255
EP - 259
BT - Proceedings of SPIE - The International Society for Optical Engineering
A2 - Knauer, James P.
A2 - Shenoy, Gopal K.
PB - Publ by Int Soc for Optical Engineering
ER -