Abstract
In this paper we discuss the potential for application of x-ray holographic imaging techniques to the sequencing of DNA. We formulate an approximate model for the scattering of partially coherent x-rays from an oriented DNA fiber and show the feasibility of reconstruction of heavy atom label positions from the x-ray scattering data. A series of simulations has been done to demonstrate the required reconstruction algorithms. An x-ray experiment is currently in progress to demonstrate the real feasibility of the technique.
| Original language | English (US) |
|---|---|
| Title of host publication | Proceedings of SPIE - The International Society for Optical Engineering |
| Editors | James P. Knauer, Gopal K. Shenoy |
| Publisher | Publ by Int Soc for Optical Engineering |
| Pages | 255-259 |
| Number of pages | 5 |
| Volume | 1345 |
| State | Published - 1990 |
| Externally published | Yes |
| Event | Advanced X-Ray/EUV Radiation Sources and Applications - San Diego, CA, USA Duration: Jul 11 1990 → Jul 13 1990 |
Other
| Other | Advanced X-Ray/EUV Radiation Sources and Applications |
|---|---|
| City | San Diego, CA, USA |
| Period | 7/11/90 → 7/13/90 |
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ASJC Scopus subject areas
- Electrical and Electronic Engineering
- Condensed Matter Physics
Cite this
Yorkey, T., Brase, J., Trebes, J., Lane, S., & Gray, J. (1990). X-ray holography for sequencing DNA. In J. P. Knauer, & G. K. Shenoy (Eds.), Proceedings of SPIE - The International Society for Optical Engineering (Vol. 1345, pp. 255-259). Publ by Int Soc for Optical Engineering.