X-ray holography for sequencing DNA

T. Yorkey; J. Brase; J. Trebes; S. Lane; J. Gray

X-ray holography for sequencing DNA

T. Yorkey, J. Brase, J. Trebes, S. Lane, J. Gray

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

In this paper we discuss the potential for application of x-ray holographic imaging techniques to the sequencing of DNA. We formulate an approximate model for the scattering of partially coherent x-rays from an oriented DNA fiber and show the feasibility of reconstruction of heavy atom label positions from the x-ray scattering data. A series of simulations has been done to demonstrate the required reconstruction algorithms. An x-ray experiment is currently in progress to demonstrate the real feasibility of the technique.

Original language	English (US)
Title of host publication	Proceedings of SPIE - The International Society for Optical Engineering
Editors	James P. Knauer, Gopal K. Shenoy
Publisher	Publ by Int Soc for Optical Engineering
Pages	255-259
Number of pages	5
Volume	1345
State	Published - 1990
Externally published	Yes
Event	Advanced X-Ray/EUV Radiation Sources and Applications - San Diego, CA, USA Duration: Jul 11 1990 → Jul 13 1990

Other

Other	Advanced X-Ray/EUV Radiation Sources and Applications
City	San Diego, CA, USA
Period	7/11/90 → 7/13/90

ASJC Scopus subject areas

Electrical and Electronic Engineering
Condensed Matter Physics

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Cite this

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title = "X-ray holography for sequencing DNA",

abstract = "In this paper we discuss the potential for application of x-ray holographic imaging techniques to the sequencing of DNA. We formulate an approximate model for the scattering of partially coherent x-rays from an oriented DNA fiber and show the feasibility of reconstruction of heavy atom label positions from the x-ray scattering data. A series of simulations has been done to demonstrate the required reconstruction algorithms. An x-ray experiment is currently in progress to demonstrate the real feasibility of the technique.",

author = "T. Yorkey and J. Brase and J. Trebes and S. Lane and J. Gray",

year = "1990",

language = "English (US)",

volume = "1345",

pages = "255--259",

editor = "Knauer, {James P.} and Shenoy, {Gopal K.}",

booktitle = "Proceedings of SPIE - The International Society for Optical Engineering",

publisher = "Publ by Int Soc for Optical Engineering",

note = "Advanced X-Ray/EUV Radiation Sources and Applications ; Conference date: 11-07-1990 Through 13-07-1990",

}

TY - GEN

T1 - X-ray holography for sequencing DNA

AU - Yorkey, T.

AU - Brase, J.

AU - Trebes, J.

AU - Lane, S.

AU - Gray, J.

PY - 1990

Y1 - 1990

N2 - In this paper we discuss the potential for application of x-ray holographic imaging techniques to the sequencing of DNA. We formulate an approximate model for the scattering of partially coherent x-rays from an oriented DNA fiber and show the feasibility of reconstruction of heavy atom label positions from the x-ray scattering data. A series of simulations has been done to demonstrate the required reconstruction algorithms. An x-ray experiment is currently in progress to demonstrate the real feasibility of the technique.

AB - In this paper we discuss the potential for application of x-ray holographic imaging techniques to the sequencing of DNA. We formulate an approximate model for the scattering of partially coherent x-rays from an oriented DNA fiber and show the feasibility of reconstruction of heavy atom label positions from the x-ray scattering data. A series of simulations has been done to demonstrate the required reconstruction algorithms. An x-ray experiment is currently in progress to demonstrate the real feasibility of the technique.

UR - http://www.scopus.com/inward/record.url?scp=0025531468&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025531468&partnerID=8YFLogxK

M3 - Conference contribution

AN - SCOPUS:0025531468

VL - 1345

SP - 255

EP - 259

BT - Proceedings of SPIE - The International Society for Optical Engineering

A2 - Knauer, James P.

A2 - Shenoy, Gopal K.

PB - Publ by Int Soc for Optical Engineering

T2 - Advanced X-Ray/EUV Radiation Sources and Applications

Y2 - 11 July 1990 through 13 July 1990

ER -