X-ray holography for sequencing DNA

T. Yorkey, J. Brase, J. Trebes, S. Lane, J. Gray

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Scopus citations

Abstract

In this paper we discuss the potential for application of x-ray holographic imaging techniques to the sequencing of DNA. We formulate an approximate model for the scattering of partially coherent x-rays from an oriented DNA fiber and show the feasibility of reconstruction of heavy atom label positions from the x-ray scattering data. A series of simulations has been done to demonstrate the required reconstruction algorithms. An x-ray experiment is currently in progress to demonstrate the real feasibility of the technique.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsJames P. Knauer, Gopal K. Shenoy
PublisherPubl by Int Soc for Optical Engineering
Pages255-259
Number of pages5
Volume1345
StatePublished - 1990
Externally publishedYes
EventAdvanced X-Ray/EUV Radiation Sources and Applications - San Diego, CA, USA
Duration: Jul 11 1990Jul 13 1990

Other

OtherAdvanced X-Ray/EUV Radiation Sources and Applications
CitySan Diego, CA, USA
Period7/11/907/13/90

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ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Yorkey, T., Brase, J., Trebes, J., Lane, S., & Gray, J. (1990). X-ray holography for sequencing DNA. In J. P. Knauer, & G. K. Shenoy (Eds.), Proceedings of SPIE - The International Society for Optical Engineering (Vol. 1345, pp. 255-259). Publ by Int Soc for Optical Engineering.