X-chromosome effects on female brain: a magnetic resonance imaging study of Turner's syndrome

D. G M Murphy, Charles DeCarli, E. Daly, J. V. Haxby, G. Allen, A. R. McIntosh, B. Horwitz, S. I. Rapoport, M. B. Schapiro, B. J. White, C. M. Powell

Research output: Contribution to journalArticle

158 Citations (Scopus)

Abstract

Summary. Many neuropsychiatric disorders differ between the sexes in incidence, symptoms, and age at onset. To investigate the effects of X-chromosome aneuploidy and of sex steroid deficiency during childhood on brain structure and function, we used neuropsychological tests and quantitative magnetic resonance imaging (MRI) to study the brains of eighteen women with Turner's syndrome (TS) and nineteen healthy control women of similar age. Nine TS subjects had mosaic 45,X karyotypes, and 9 had non-mosaic 45,X. The TS group had significantly lower scores than the controls for all the Wechsler adult intelligence scale tests, except verbal comprehension and reading level. The greatest difference was in visuospatial construction (mean 90 [SD 12] vs 118 [13], p < 0·0001). The TS subjects also had a greater discrepancy than controls between verbal and performance intelligence quotients (9 [8] vs -5 [9], p<0 001). We found that TS subjects had significantly smaller values than controls in MRI-measured volumes of hippocampus, caudate, lenticular, and thalamic nuclei, and parieto-occipital brain matter, on both sides. Women with mosaic TS had values between the full TS and control groups for cerebral hemisphere and lenticular and thalamic nuclei volume and for verbal ability. Within the mosaic TS group, visuospatial ability was significantly correlated with the percentage of lymphocytes that had the 45,X karyotype. Hippocampal volume and memory test scores were significantly lower in mosaic and non-mosaic 45,XTS subjects than in controls. We postulate that in human beings the X chromosome plays an important part in the development and ageing of grey matter in striatum, diencephalon, and cerebral hemispheres.

Original languageEnglish (US)
Pages (from-to)1197-1200
Number of pages4
JournalThe Lancet
Volume342
Issue number8881
DOIs
StatePublished - Nov 13 1993
Externally publishedYes

Fingerprint

Turner Syndrome
X Chromosome
Magnetic Resonance Imaging
Brain
Corpus Striatum
Thalamic Nuclei
Aptitude
Cerebrum
Karyotype
Chromosomes, Human, X
Diencephalon
Intelligence Tests
Caudate Nucleus
Neuropsychological Tests
Aneuploidy
Intelligence
Age of Onset
Reading
Hippocampus
Steroids

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Murphy, D. G. M., DeCarli, C., Daly, E., Haxby, J. V., Allen, G., McIntosh, A. R., ... Powell, C. M. (1993). X-chromosome effects on female brain: a magnetic resonance imaging study of Turner's syndrome. The Lancet, 342(8881), 1197-1200. https://doi.org/10.1016/0140-6736(93)92184-U

X-chromosome effects on female brain : a magnetic resonance imaging study of Turner's syndrome. / Murphy, D. G M; DeCarli, Charles; Daly, E.; Haxby, J. V.; Allen, G.; McIntosh, A. R.; Horwitz, B.; Rapoport, S. I.; Schapiro, M. B.; White, B. J.; Powell, C. M.

In: The Lancet, Vol. 342, No. 8881, 13.11.1993, p. 1197-1200.

Research output: Contribution to journalArticle

Murphy, DGM, DeCarli, C, Daly, E, Haxby, JV, Allen, G, McIntosh, AR, Horwitz, B, Rapoport, SI, Schapiro, MB, White, BJ & Powell, CM 1993, 'X-chromosome effects on female brain: a magnetic resonance imaging study of Turner's syndrome', The Lancet, vol. 342, no. 8881, pp. 1197-1200. https://doi.org/10.1016/0140-6736(93)92184-U
Murphy, D. G M ; DeCarli, Charles ; Daly, E. ; Haxby, J. V. ; Allen, G. ; McIntosh, A. R. ; Horwitz, B. ; Rapoport, S. I. ; Schapiro, M. B. ; White, B. J. ; Powell, C. M. / X-chromosome effects on female brain : a magnetic resonance imaging study of Turner's syndrome. In: The Lancet. 1993 ; Vol. 342, No. 8881. pp. 1197-1200.
@article{ba6adab0692b4b5bb2024efca055ab1e,
title = "X-chromosome effects on female brain: a magnetic resonance imaging study of Turner's syndrome",
abstract = "Summary. Many neuropsychiatric disorders differ between the sexes in incidence, symptoms, and age at onset. To investigate the effects of X-chromosome aneuploidy and of sex steroid deficiency during childhood on brain structure and function, we used neuropsychological tests and quantitative magnetic resonance imaging (MRI) to study the brains of eighteen women with Turner's syndrome (TS) and nineteen healthy control women of similar age. Nine TS subjects had mosaic 45,X karyotypes, and 9 had non-mosaic 45,X. The TS group had significantly lower scores than the controls for all the Wechsler adult intelligence scale tests, except verbal comprehension and reading level. The greatest difference was in visuospatial construction (mean 90 [SD 12] vs 118 [13], p < 0·0001). The TS subjects also had a greater discrepancy than controls between verbal and performance intelligence quotients (9 [8] vs -5 [9], p<0 001). We found that TS subjects had significantly smaller values than controls in MRI-measured volumes of hippocampus, caudate, lenticular, and thalamic nuclei, and parieto-occipital brain matter, on both sides. Women with mosaic TS had values between the full TS and control groups for cerebral hemisphere and lenticular and thalamic nuclei volume and for verbal ability. Within the mosaic TS group, visuospatial ability was significantly correlated with the percentage of lymphocytes that had the 45,X karyotype. Hippocampal volume and memory test scores were significantly lower in mosaic and non-mosaic 45,XTS subjects than in controls. We postulate that in human beings the X chromosome plays an important part in the development and ageing of grey matter in striatum, diencephalon, and cerebral hemispheres.",
author = "Murphy, {D. G M} and Charles DeCarli and E. Daly and Haxby, {J. V.} and G. Allen and McIntosh, {A. R.} and B. Horwitz and Rapoport, {S. I.} and Schapiro, {M. B.} and White, {B. J.} and Powell, {C. M.}",
year = "1993",
month = "11",
day = "13",
doi = "10.1016/0140-6736(93)92184-U",
language = "English (US)",
volume = "342",
pages = "1197--1200",
journal = "The Lancet",
issn = "0140-6736",
publisher = "Elsevier Limited",
number = "8881",

}

TY - JOUR

T1 - X-chromosome effects on female brain

T2 - a magnetic resonance imaging study of Turner's syndrome

AU - Murphy, D. G M

AU - DeCarli, Charles

AU - Daly, E.

AU - Haxby, J. V.

AU - Allen, G.

AU - McIntosh, A. R.

AU - Horwitz, B.

AU - Rapoport, S. I.

AU - Schapiro, M. B.

AU - White, B. J.

AU - Powell, C. M.

PY - 1993/11/13

Y1 - 1993/11/13

N2 - Summary. Many neuropsychiatric disorders differ between the sexes in incidence, symptoms, and age at onset. To investigate the effects of X-chromosome aneuploidy and of sex steroid deficiency during childhood on brain structure and function, we used neuropsychological tests and quantitative magnetic resonance imaging (MRI) to study the brains of eighteen women with Turner's syndrome (TS) and nineteen healthy control women of similar age. Nine TS subjects had mosaic 45,X karyotypes, and 9 had non-mosaic 45,X. The TS group had significantly lower scores than the controls for all the Wechsler adult intelligence scale tests, except verbal comprehension and reading level. The greatest difference was in visuospatial construction (mean 90 [SD 12] vs 118 [13], p < 0·0001). The TS subjects also had a greater discrepancy than controls between verbal and performance intelligence quotients (9 [8] vs -5 [9], p<0 001). We found that TS subjects had significantly smaller values than controls in MRI-measured volumes of hippocampus, caudate, lenticular, and thalamic nuclei, and parieto-occipital brain matter, on both sides. Women with mosaic TS had values between the full TS and control groups for cerebral hemisphere and lenticular and thalamic nuclei volume and for verbal ability. Within the mosaic TS group, visuospatial ability was significantly correlated with the percentage of lymphocytes that had the 45,X karyotype. Hippocampal volume and memory test scores were significantly lower in mosaic and non-mosaic 45,XTS subjects than in controls. We postulate that in human beings the X chromosome plays an important part in the development and ageing of grey matter in striatum, diencephalon, and cerebral hemispheres.

AB - Summary. Many neuropsychiatric disorders differ between the sexes in incidence, symptoms, and age at onset. To investigate the effects of X-chromosome aneuploidy and of sex steroid deficiency during childhood on brain structure and function, we used neuropsychological tests and quantitative magnetic resonance imaging (MRI) to study the brains of eighteen women with Turner's syndrome (TS) and nineteen healthy control women of similar age. Nine TS subjects had mosaic 45,X karyotypes, and 9 had non-mosaic 45,X. The TS group had significantly lower scores than the controls for all the Wechsler adult intelligence scale tests, except verbal comprehension and reading level. The greatest difference was in visuospatial construction (mean 90 [SD 12] vs 118 [13], p < 0·0001). The TS subjects also had a greater discrepancy than controls between verbal and performance intelligence quotients (9 [8] vs -5 [9], p<0 001). We found that TS subjects had significantly smaller values than controls in MRI-measured volumes of hippocampus, caudate, lenticular, and thalamic nuclei, and parieto-occipital brain matter, on both sides. Women with mosaic TS had values between the full TS and control groups for cerebral hemisphere and lenticular and thalamic nuclei volume and for verbal ability. Within the mosaic TS group, visuospatial ability was significantly correlated with the percentage of lymphocytes that had the 45,X karyotype. Hippocampal volume and memory test scores were significantly lower in mosaic and non-mosaic 45,XTS subjects than in controls. We postulate that in human beings the X chromosome plays an important part in the development and ageing of grey matter in striatum, diencephalon, and cerebral hemispheres.

UR - http://www.scopus.com/inward/record.url?scp=0027384938&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027384938&partnerID=8YFLogxK

U2 - 10.1016/0140-6736(93)92184-U

DO - 10.1016/0140-6736(93)92184-U

M3 - Article

C2 - 7901528

AN - SCOPUS:0027384938

VL - 342

SP - 1197

EP - 1200

JO - The Lancet

JF - The Lancet

SN - 0140-6736

IS - 8881

ER -