WT1 as a substrate of HtrA2: A potential pathway for therapeutic targeting by HtrA proteases

Research output: Contribution to journalComment/debate

2 Citations (Scopus)

Abstract

WT1 is a transcription factor first cloned in 1990 as a tumor suppressor, and inactivating deletions and mutations in WT1 are found in childhood kidney Wilms tumor. The tumor suppressive role of WT1 is further supported by in vitro and in vivo studies in which ectopic expression of WT1 attenuated cell growth and tumor formation by promoting apoptosis through induction of proapoptotic proteins. However, WT1 is also reported to be overexpressed in adult cancer, and the functional significance of overexpression or de novo expression of WT in adult cancers is not clear, although WT1 in adult cancer may represent isoform-specific differences in WT1 function. A paper by Hartkamp et al. is discussed in this article, reporting the identification of Wilms tumor suppressor protein WT1 as a substrate of serine protease HtrA2 and the contribution of potential mechanistic insights into how distinct WT1 functions may be regulated through proteolysis by HtrA2.

Original languageEnglish (US)
Pages (from-to)1233-1235
Number of pages3
JournalFuture Oncology
Volume6
Issue number8
DOIs
StatePublished - Aug 1 2010
Externally publishedYes

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Peptide Hydrolases
Neoplasms
Wilms Tumor
Therapeutics
Tumor Suppressor Proteins
Sequence Deletion
Serine Proteases
Proteolysis
Protein Isoforms
Transcription Factors
Apoptosis
Kidney
Growth
Proteins

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

WT1 as a substrate of HtrA2 : A potential pathway for therapeutic targeting by HtrA proteases. / Chien, Jeremy.

In: Future Oncology, Vol. 6, No. 8, 01.08.2010, p. 1233-1235.

Research output: Contribution to journalComment/debate

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