Workshop to identify critical windows of exposure for children's health: Immune and respiratory systems work group summary

Rodney R. Dietert, Ruth A. Etzel, David Chen, Marilyn Halonen, Steven D. Holladay, Annie M. Jarabek, Kenneth Landreth, David B. Peden, Kent E Pinkerton, Ralph J. Smialowicz, Tracey Zoetis

Research output: Contribution to journalArticle

226 Citations (Scopus)

Abstract

Fetuses, infants, and juveniles (preadults) should not be considered simply ″small adults″ when it comes to toxicological risk. We present specific examples of developmental toxicants that are more toxic to children than to adults, focusing on effects on the immune and respiratory systems. We describe differences in both the pharmacokinetics of the developing immune and respiratory systems as well as changes in target organ sensitivities to toxicants. Differential windows of vulnerability during development are identified in the context of available animal models. We provide specific approaches to directly investigate differential windows of vulnerability. These approaches are based on fundamental developmental biology and the existence of discrete developmental processes within the immune and respiratory systems. The processes are likely to influence differential developmental susceptibility to toxicants, resulting in lifelong toxicological changes. We also provide a template for comparative research. Finally, we discuss the application of these data to risk assessment.

Original languageEnglish (US)
Pages (from-to)483-490
Number of pages8
JournalEnvironmental Health Perspectives
Volume108
Issue numberSUPPL. 3
StatePublished - 2000

Fingerprint

Respiratory system
child health
Immune system
immune system
Respiratory System
Immune System
Health
Education
Toxicology
vulnerability
developmental biology
Developmental Biology
Pharmacokinetics
Poisons
Risk assessment
Animals
Fetus
risk assessment
Animal Models
animal

Keywords

  • Children's health
  • Developmental exposure
  • Developmental immunotoxicity
  • Respiratory toxicity
  • Risk assessment
  • Windows of vulnerability

ASJC Scopus subject areas

  • Environmental Science(all)
  • Environmental Chemistry
  • Public Health, Environmental and Occupational Health

Cite this

Dietert, R. R., Etzel, R. A., Chen, D., Halonen, M., Holladay, S. D., Jarabek, A. M., ... Zoetis, T. (2000). Workshop to identify critical windows of exposure for children's health: Immune and respiratory systems work group summary. Environmental Health Perspectives, 108(SUPPL. 3), 483-490.

Workshop to identify critical windows of exposure for children's health : Immune and respiratory systems work group summary. / Dietert, Rodney R.; Etzel, Ruth A.; Chen, David; Halonen, Marilyn; Holladay, Steven D.; Jarabek, Annie M.; Landreth, Kenneth; Peden, David B.; Pinkerton, Kent E; Smialowicz, Ralph J.; Zoetis, Tracey.

In: Environmental Health Perspectives, Vol. 108, No. SUPPL. 3, 2000, p. 483-490.

Research output: Contribution to journalArticle

Dietert, RR, Etzel, RA, Chen, D, Halonen, M, Holladay, SD, Jarabek, AM, Landreth, K, Peden, DB, Pinkerton, KE, Smialowicz, RJ & Zoetis, T 2000, 'Workshop to identify critical windows of exposure for children's health: Immune and respiratory systems work group summary', Environmental Health Perspectives, vol. 108, no. SUPPL. 3, pp. 483-490.
Dietert, Rodney R. ; Etzel, Ruth A. ; Chen, David ; Halonen, Marilyn ; Holladay, Steven D. ; Jarabek, Annie M. ; Landreth, Kenneth ; Peden, David B. ; Pinkerton, Kent E ; Smialowicz, Ralph J. ; Zoetis, Tracey. / Workshop to identify critical windows of exposure for children's health : Immune and respiratory systems work group summary. In: Environmental Health Perspectives. 2000 ; Vol. 108, No. SUPPL. 3. pp. 483-490.
@article{4ebc42fa12964d3587f5e8ed4f5e7821,
title = "Workshop to identify critical windows of exposure for children's health: Immune and respiratory systems work group summary",
abstract = "Fetuses, infants, and juveniles (preadults) should not be considered simply ″small adults″ when it comes to toxicological risk. We present specific examples of developmental toxicants that are more toxic to children than to adults, focusing on effects on the immune and respiratory systems. We describe differences in both the pharmacokinetics of the developing immune and respiratory systems as well as changes in target organ sensitivities to toxicants. Differential windows of vulnerability during development are identified in the context of available animal models. We provide specific approaches to directly investigate differential windows of vulnerability. These approaches are based on fundamental developmental biology and the existence of discrete developmental processes within the immune and respiratory systems. The processes are likely to influence differential developmental susceptibility to toxicants, resulting in lifelong toxicological changes. We also provide a template for comparative research. Finally, we discuss the application of these data to risk assessment.",
keywords = "Children's health, Developmental exposure, Developmental immunotoxicity, Respiratory toxicity, Risk assessment, Windows of vulnerability",
author = "Dietert, {Rodney R.} and Etzel, {Ruth A.} and David Chen and Marilyn Halonen and Holladay, {Steven D.} and Jarabek, {Annie M.} and Kenneth Landreth and Peden, {David B.} and Pinkerton, {Kent E} and Smialowicz, {Ralph J.} and Tracey Zoetis",
year = "2000",
language = "English (US)",
volume = "108",
pages = "483--490",
journal = "Environmental Health Perspectives",
issn = "0091-6765",
publisher = "Public Health Services, US Dept of Health and Human Services",
number = "SUPPL. 3",

}

TY - JOUR

T1 - Workshop to identify critical windows of exposure for children's health

T2 - Immune and respiratory systems work group summary

AU - Dietert, Rodney R.

AU - Etzel, Ruth A.

AU - Chen, David

AU - Halonen, Marilyn

AU - Holladay, Steven D.

AU - Jarabek, Annie M.

AU - Landreth, Kenneth

AU - Peden, David B.

AU - Pinkerton, Kent E

AU - Smialowicz, Ralph J.

AU - Zoetis, Tracey

PY - 2000

Y1 - 2000

N2 - Fetuses, infants, and juveniles (preadults) should not be considered simply ″small adults″ when it comes to toxicological risk. We present specific examples of developmental toxicants that are more toxic to children than to adults, focusing on effects on the immune and respiratory systems. We describe differences in both the pharmacokinetics of the developing immune and respiratory systems as well as changes in target organ sensitivities to toxicants. Differential windows of vulnerability during development are identified in the context of available animal models. We provide specific approaches to directly investigate differential windows of vulnerability. These approaches are based on fundamental developmental biology and the existence of discrete developmental processes within the immune and respiratory systems. The processes are likely to influence differential developmental susceptibility to toxicants, resulting in lifelong toxicological changes. We also provide a template for comparative research. Finally, we discuss the application of these data to risk assessment.

AB - Fetuses, infants, and juveniles (preadults) should not be considered simply ″small adults″ when it comes to toxicological risk. We present specific examples of developmental toxicants that are more toxic to children than to adults, focusing on effects on the immune and respiratory systems. We describe differences in both the pharmacokinetics of the developing immune and respiratory systems as well as changes in target organ sensitivities to toxicants. Differential windows of vulnerability during development are identified in the context of available animal models. We provide specific approaches to directly investigate differential windows of vulnerability. These approaches are based on fundamental developmental biology and the existence of discrete developmental processes within the immune and respiratory systems. The processes are likely to influence differential developmental susceptibility to toxicants, resulting in lifelong toxicological changes. We also provide a template for comparative research. Finally, we discuss the application of these data to risk assessment.

KW - Children's health

KW - Developmental exposure

KW - Developmental immunotoxicity

KW - Respiratory toxicity

KW - Risk assessment

KW - Windows of vulnerability

UR - http://www.scopus.com/inward/record.url?scp=0033939623&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033939623&partnerID=8YFLogxK

M3 - Article

C2 - 10852848

AN - SCOPUS:0033939623

VL - 108

SP - 483

EP - 490

JO - Environmental Health Perspectives

JF - Environmental Health Perspectives

SN - 0091-6765

IS - SUPPL. 3

ER -