TY - JOUR
T1 - Working memory maintenance contributes to long-term memory formation
T2 - Neural and behavioral evidence
AU - Ranganath, Charan
AU - Cohen, Michael X.
AU - Brozinsky, Craig J.
PY - 2005/7
Y1 - 2005/7
N2 - Theories of human memory have led to conflicting views regarding the relationship between working memory (WM) maintenance and episodic long-term memory (LTM) formation. Here, we tested the prediction that WM maintenance operates in two stages, and that processing during the initial stage of WM maintenance promotes successful LTM formation. Results from a functional magnetic resonance imaging study showed that activity in the dorsolateral prefrontal cortex and hippocampus during the initial stage of WM maintenance was predictive of subsequent LTM performance. In a behavioral experiment, we demonstrated that interfering with processing during the initial stage of WM maintenance impaired LTM formation. These results demonstrate that processing during the initial stage of WM maintenance directly contributes to successful LTM formation, and that this effect is mediated by a network that includes the dorsolateral prefrontal cortex and the hippocampus.
AB - Theories of human memory have led to conflicting views regarding the relationship between working memory (WM) maintenance and episodic long-term memory (LTM) formation. Here, we tested the prediction that WM maintenance operates in two stages, and that processing during the initial stage of WM maintenance promotes successful LTM formation. Results from a functional magnetic resonance imaging study showed that activity in the dorsolateral prefrontal cortex and hippocampus during the initial stage of WM maintenance was predictive of subsequent LTM performance. In a behavioral experiment, we demonstrated that interfering with processing during the initial stage of WM maintenance impaired LTM formation. These results demonstrate that processing during the initial stage of WM maintenance directly contributes to successful LTM formation, and that this effect is mediated by a network that includes the dorsolateral prefrontal cortex and the hippocampus.
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U2 - 10.1162/0898929054475118
DO - 10.1162/0898929054475118
M3 - Article
C2 - 16102232
AN - SCOPUS:22944469123
VL - 17
SP - 994
EP - 1010
JO - Journal of Cognitive Neuroscience
JF - Journal of Cognitive Neuroscience
SN - 0898-929X
IS - 7
ER -