Working memory in attention deficit/hyperactivity disorder is characterized by a lack of specialization of brain function

Catherine Fassbender, Julie B Schweitzer, Carlos R. Cortes, Malle A. Tagamets, T. Andrew Windsor, Gloria M. Reeves, Rao Gullapalli

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Working memory impairments are frequent in Attention Deficit/Hyperactivity Disorder (ADHD) and create problems along numerous functional dimensions. The present study utilized the Visual Serial Addition Task (VSAT) and functional magnetic resonance imaging (fMRI) to explore working memory processes in thirteen typically developing (TD) control and thirteen children with ADHD, Combined type. Analysis of Variance (ANOVA) was used to examine both main effects and interactions. Working memory-specific activity was found in TD children in the bilateral prefrontal cortex. In contrast the within-group map in ADHD did not reveal any working-memory specific regions. Main effects of condition suggested that the right middle frontal gyrus (BA6) and the right precuneus were engaged by both groups during working memory processing. Group differences were driven by significantly greater, non-working memory-specific, activation in the ADHD relative to TD group in the bilateral insula extending into basal ganglia and the medial prefrontal cortex. A region of interest analysis revealed a region in left middle frontal gyrus that was more active during working memory in TD controls. Thus, only the TD group appeared to display working memory-modulated brain activation. In conclusion, children with ADHD demonstrated reduced working memory task specific brain activation in comparison to their peers. These data suggest inefficiency in functional recruitment by individuals with ADHD represented by a poor match between task demands and appropriate levels of brain activity.

Original languageEnglish (US)
Article numbere27240
JournalPLoS One
Volume6
Issue number11
DOIs
StatePublished - Nov 10 2011

Fingerprint

Attention Deficit Disorder with Hyperactivity
Short-Term Memory
Brain
brain
Data storage equipment
Prefrontal Cortex
Chemical activation
Parietal Lobe
Basal Ganglia
peers
Analysis of variance (ANOVA)
magnetic resonance imaging
Analysis of Variance
Magnetic Resonance Imaging
analysis of variance
Processing

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Working memory in attention deficit/hyperactivity disorder is characterized by a lack of specialization of brain function. / Fassbender, Catherine; Schweitzer, Julie B; Cortes, Carlos R.; Tagamets, Malle A.; Windsor, T. Andrew; Reeves, Gloria M.; Gullapalli, Rao.

In: PLoS One, Vol. 6, No. 11, e27240, 10.11.2011.

Research output: Contribution to journalArticle

Fassbender, Catherine ; Schweitzer, Julie B ; Cortes, Carlos R. ; Tagamets, Malle A. ; Windsor, T. Andrew ; Reeves, Gloria M. ; Gullapalli, Rao. / Working memory in attention deficit/hyperactivity disorder is characterized by a lack of specialization of brain function. In: PLoS One. 2011 ; Vol. 6, No. 11.
@article{796c28b49c564d4b958355ba71af31f8,
title = "Working memory in attention deficit/hyperactivity disorder is characterized by a lack of specialization of brain function",
abstract = "Working memory impairments are frequent in Attention Deficit/Hyperactivity Disorder (ADHD) and create problems along numerous functional dimensions. The present study utilized the Visual Serial Addition Task (VSAT) and functional magnetic resonance imaging (fMRI) to explore working memory processes in thirteen typically developing (TD) control and thirteen children with ADHD, Combined type. Analysis of Variance (ANOVA) was used to examine both main effects and interactions. Working memory-specific activity was found in TD children in the bilateral prefrontal cortex. In contrast the within-group map in ADHD did not reveal any working-memory specific regions. Main effects of condition suggested that the right middle frontal gyrus (BA6) and the right precuneus were engaged by both groups during working memory processing. Group differences were driven by significantly greater, non-working memory-specific, activation in the ADHD relative to TD group in the bilateral insula extending into basal ganglia and the medial prefrontal cortex. A region of interest analysis revealed a region in left middle frontal gyrus that was more active during working memory in TD controls. Thus, only the TD group appeared to display working memory-modulated brain activation. In conclusion, children with ADHD demonstrated reduced working memory task specific brain activation in comparison to their peers. These data suggest inefficiency in functional recruitment by individuals with ADHD represented by a poor match between task demands and appropriate levels of brain activity.",
author = "Catherine Fassbender and Schweitzer, {Julie B} and Cortes, {Carlos R.} and Tagamets, {Malle A.} and Windsor, {T. Andrew} and Reeves, {Gloria M.} and Rao Gullapalli",
year = "2011",
month = "11",
day = "10",
doi = "10.1371/journal.pone.0027240",
language = "English (US)",
volume = "6",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "11",

}

TY - JOUR

T1 - Working memory in attention deficit/hyperactivity disorder is characterized by a lack of specialization of brain function

AU - Fassbender, Catherine

AU - Schweitzer, Julie B

AU - Cortes, Carlos R.

AU - Tagamets, Malle A.

AU - Windsor, T. Andrew

AU - Reeves, Gloria M.

AU - Gullapalli, Rao

PY - 2011/11/10

Y1 - 2011/11/10

N2 - Working memory impairments are frequent in Attention Deficit/Hyperactivity Disorder (ADHD) and create problems along numerous functional dimensions. The present study utilized the Visual Serial Addition Task (VSAT) and functional magnetic resonance imaging (fMRI) to explore working memory processes in thirteen typically developing (TD) control and thirteen children with ADHD, Combined type. Analysis of Variance (ANOVA) was used to examine both main effects and interactions. Working memory-specific activity was found in TD children in the bilateral prefrontal cortex. In contrast the within-group map in ADHD did not reveal any working-memory specific regions. Main effects of condition suggested that the right middle frontal gyrus (BA6) and the right precuneus were engaged by both groups during working memory processing. Group differences were driven by significantly greater, non-working memory-specific, activation in the ADHD relative to TD group in the bilateral insula extending into basal ganglia and the medial prefrontal cortex. A region of interest analysis revealed a region in left middle frontal gyrus that was more active during working memory in TD controls. Thus, only the TD group appeared to display working memory-modulated brain activation. In conclusion, children with ADHD demonstrated reduced working memory task specific brain activation in comparison to their peers. These data suggest inefficiency in functional recruitment by individuals with ADHD represented by a poor match between task demands and appropriate levels of brain activity.

AB - Working memory impairments are frequent in Attention Deficit/Hyperactivity Disorder (ADHD) and create problems along numerous functional dimensions. The present study utilized the Visual Serial Addition Task (VSAT) and functional magnetic resonance imaging (fMRI) to explore working memory processes in thirteen typically developing (TD) control and thirteen children with ADHD, Combined type. Analysis of Variance (ANOVA) was used to examine both main effects and interactions. Working memory-specific activity was found in TD children in the bilateral prefrontal cortex. In contrast the within-group map in ADHD did not reveal any working-memory specific regions. Main effects of condition suggested that the right middle frontal gyrus (BA6) and the right precuneus were engaged by both groups during working memory processing. Group differences were driven by significantly greater, non-working memory-specific, activation in the ADHD relative to TD group in the bilateral insula extending into basal ganglia and the medial prefrontal cortex. A region of interest analysis revealed a region in left middle frontal gyrus that was more active during working memory in TD controls. Thus, only the TD group appeared to display working memory-modulated brain activation. In conclusion, children with ADHD demonstrated reduced working memory task specific brain activation in comparison to their peers. These data suggest inefficiency in functional recruitment by individuals with ADHD represented by a poor match between task demands and appropriate levels of brain activity.

UR - http://www.scopus.com/inward/record.url?scp=80755176799&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80755176799&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0027240

DO - 10.1371/journal.pone.0027240

M3 - Article

C2 - 22102882

AN - SCOPUS:80755176799

VL - 6

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 11

M1 - e27240

ER -