Working memory deficits, increased anxiety-like traits, and seizure susceptibility in BDNF overexpressing mice

Francesco Papaleo, Jill L Silverman, Jordan Aney, Qingjun Tian, Charlotte L. Barkan, Kathryn K. Chadman, Jacqueline Crawley

Research output: Contribution to journalArticlepeer-review

84 Scopus citations

Abstract

BDNF regulates components of cognitive processes and has been implicated in psychiatric disorders. Here we report that genetic overexpression of the BDNF mature isoform (BDNF-tg) in female mice impaired working memory functions while sparing components of fear conditioning. BDNF-tg mice also displayed reduced breeding efficiency, higher anxiety-like scores, high self-grooming, impaired prepulse inhibition, and higher susceptibility to seizures when placed in a new empty cage, as compared with wild-type (WT) littermate controls. Control measures of general health, locomotor activity, motor coordination, depression-related behaviors, and sociability did not differ between genotypes. The present findings, indicating detrimental effects of life-long increased BDNF in mice, may inform human studies evaluating the role of BDNF functional genetic variations on cognitive abilities and vulnerability to psychiatric disorders.

Original languageEnglish (US)
Pages (from-to)534-544
Number of pages11
JournalLearning and Memory
Volume18
Issue number8
DOIs
StatePublished - Aug 2011
Externally publishedYes

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience
  • Neuropsychology and Physiological Psychology

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