Working memory deficits, increased anxiety-like traits, and seizure susceptibility in BDNF overexpressing mice

Francesco Papaleo, Jill L Silverman, Jordan Aney, Qingjun Tian, Charlotte L. Barkan, Kathryn K. Chadman, Jacqueline Crawley

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

BDNF regulates components of cognitive processes and has been implicated in psychiatric disorders. Here we report that genetic overexpression of the BDNF mature isoform (BDNF-tg) in female mice impaired working memory functions while sparing components of fear conditioning. BDNF-tg mice also displayed reduced breeding efficiency, higher anxiety-like scores, high self-grooming, impaired prepulse inhibition, and higher susceptibility to seizures when placed in a new empty cage, as compared with wild-type (WT) littermate controls. Control measures of general health, locomotor activity, motor coordination, depression-related behaviors, and sociability did not differ between genotypes. The present findings, indicating detrimental effects of life-long increased BDNF in mice, may inform human studies evaluating the role of BDNF functional genetic variations on cognitive abilities and vulnerability to psychiatric disorders.

Original languageEnglish (US)
Pages (from-to)534-544
Number of pages11
JournalLearning and Memory
Volume18
Issue number8
DOIs
StatePublished - Aug 2011
Externally publishedYes

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Brain-Derived Neurotrophic Factor
Memory Disorders
Short-Term Memory
Seizures
Anxiety
Psychiatry
Grooming
Aptitude
Locomotion
Fear
Breeding
Protein Isoforms
Genotype
Depression
Efficiency
Health

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience
  • Neuropsychology and Physiological Psychology

Cite this

Working memory deficits, increased anxiety-like traits, and seizure susceptibility in BDNF overexpressing mice. / Papaleo, Francesco; Silverman, Jill L; Aney, Jordan; Tian, Qingjun; Barkan, Charlotte L.; Chadman, Kathryn K.; Crawley, Jacqueline.

In: Learning and Memory, Vol. 18, No. 8, 08.2011, p. 534-544.

Research output: Contribution to journalArticle

Papaleo, Francesco ; Silverman, Jill L ; Aney, Jordan ; Tian, Qingjun ; Barkan, Charlotte L. ; Chadman, Kathryn K. ; Crawley, Jacqueline. / Working memory deficits, increased anxiety-like traits, and seizure susceptibility in BDNF overexpressing mice. In: Learning and Memory. 2011 ; Vol. 18, No. 8. pp. 534-544.
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