Women with cervicovaginal antibody-dependent cell-mediated cytotoxicity have lower genital HIV-1 RNA Loads

Pratip Nag, Jenney Kim, Vytautas Sapiega, Alan L. Landay, James W. Bremer, Jiri Mestecky, Patricia Reichelderfer, Andrea Kovacs, Jonathan Cohn, Barbara Weiser, Linda L. Baum

Research output: Contribution to journalArticle

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Abstract

Antibodies that mediate human immunodeficiency virus (HIV)-specific antibody-dependent cell-mediated cytotoxicity (ADCC) are present in the cervical fluid of many HIV-positive women; however, the role that these antibodies play in host defense against HIV is not known. To understand the contribution of ADCC in cervical secretions as a protective mechanism against HIV, we evaluated ADCC titers in paired serum and cervical-lavage (CVL) samples from >300 HIV-1-positive women who participated in the multicenter Division of AIDS Treatment Research Initiative Study 009. The present study demonstrates that women with CVL ADCC activity had lower genital viral loads than did women with serum ADCC activity only. Women with CVL ADCC activity were likely to have HIV-1 gp120-specific immunoglobulin (Ig) G, but not IgA, in their cervical fluid. This finding suggests that specific IgG in cervical fluid can mediate ADCC activity that inversely correlates with genital viral load.

Original languageEnglish (US)
Pages (from-to)1970-1978
Number of pages9
JournalJournal of Infectious Diseases
Volume190
Issue number11
DOIs
StatePublished - Dec 1 2004
Externally publishedYes

Fingerprint

Antibody-Dependent Cell Cytotoxicity
HIV-1
RNA
Therapeutic Irrigation
HIV
Viral Load
Immunoglobulin G
Antibodies
Serum
Immunoglobulin A
Acquired Immunodeficiency Syndrome
Research

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Nag, P., Kim, J., Sapiega, V., Landay, A. L., Bremer, J. W., Mestecky, J., ... Baum, L. L. (2004). Women with cervicovaginal antibody-dependent cell-mediated cytotoxicity have lower genital HIV-1 RNA Loads. Journal of Infectious Diseases, 190(11), 1970-1978. https://doi.org/10.1086/425582

Women with cervicovaginal antibody-dependent cell-mediated cytotoxicity have lower genital HIV-1 RNA Loads. / Nag, Pratip; Kim, Jenney; Sapiega, Vytautas; Landay, Alan L.; Bremer, James W.; Mestecky, Jiri; Reichelderfer, Patricia; Kovacs, Andrea; Cohn, Jonathan; Weiser, Barbara; Baum, Linda L.

In: Journal of Infectious Diseases, Vol. 190, No. 11, 01.12.2004, p. 1970-1978.

Research output: Contribution to journalArticle

Nag, P, Kim, J, Sapiega, V, Landay, AL, Bremer, JW, Mestecky, J, Reichelderfer, P, Kovacs, A, Cohn, J, Weiser, B & Baum, LL 2004, 'Women with cervicovaginal antibody-dependent cell-mediated cytotoxicity have lower genital HIV-1 RNA Loads', Journal of Infectious Diseases, vol. 190, no. 11, pp. 1970-1978. https://doi.org/10.1086/425582
Nag, Pratip ; Kim, Jenney ; Sapiega, Vytautas ; Landay, Alan L. ; Bremer, James W. ; Mestecky, Jiri ; Reichelderfer, Patricia ; Kovacs, Andrea ; Cohn, Jonathan ; Weiser, Barbara ; Baum, Linda L. / Women with cervicovaginal antibody-dependent cell-mediated cytotoxicity have lower genital HIV-1 RNA Loads. In: Journal of Infectious Diseases. 2004 ; Vol. 190, No. 11. pp. 1970-1978.
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