WISP-1 is a Wnt-1- and β-catenin-responsive oncogene

Lifeng Xu, Ryan B. Corcoran, James W. Welsh, Diane Pennica, Arnold J. Levine

Research output: Contribution to journalArticle

272 Scopus citations

Abstract

WISP-1 (Wnt-1 induced secreted protein 1) is a member of the CCN family of growth factors. This study identifies WISP-1 as a β-catenin-regulated gene that can contribute to tumorigenesis. The promoter of WISP-1 was cloned and shown to be activated by both Wnt-1 and β-catenin expression. TCF/LEF sites played a minor role, whereas the CREB site played an important role in this transcriptional activation. WISP-1 demonstrated oncogenic activities; overexpression of WISP-1 in normal rat kidney fibroblast cells (NRK-49F) induced morphological transformation, accelerated cell growth, and enhanced saturation density. Although these cells did not acquire anchorage- independent growth in soft agar, they readily formed tumors in nude mice, suggesting that appropriate cellular attachment is important for signaling oncogenic events downstream of WISP-1.

Original languageEnglish (US)
Pages (from-to)585-595
Number of pages11
JournalGenes and Development
Volume14
Issue number5
StatePublished - Mar 1 2000
Externally publishedYes

Keywords

  • β-catenin
  • Oncogene
  • WISP-1
  • Wnt-1

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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    Xu, L., Corcoran, R. B., Welsh, J. W., Pennica, D., & Levine, A. J. (2000). WISP-1 is a Wnt-1- and β-catenin-responsive oncogene. Genes and Development, 14(5), 585-595.