WISP-1 is a Wnt-1- and β-catenin-responsive oncogene

Lifeng Xu, Ryan B. Corcoran, James W. Welsh, Diane Pennica, Arnold J. Levine

Research output: Contribution to journalArticle

268 Citations (Scopus)

Abstract

WISP-1 (Wnt-1 induced secreted protein 1) is a member of the CCN family of growth factors. This study identifies WISP-1 as a β-catenin-regulated gene that can contribute to tumorigenesis. The promoter of WISP-1 was cloned and shown to be activated by both Wnt-1 and β-catenin expression. TCF/LEF sites played a minor role, whereas the CREB site played an important role in this transcriptional activation. WISP-1 demonstrated oncogenic activities; overexpression of WISP-1 in normal rat kidney fibroblast cells (NRK-49F) induced morphological transformation, accelerated cell growth, and enhanced saturation density. Although these cells did not acquire anchorage- independent growth in soft agar, they readily formed tumors in nude mice, suggesting that appropriate cellular attachment is important for signaling oncogenic events downstream of WISP-1.

Original languageEnglish (US)
Pages (from-to)585-595
Number of pages11
JournalGenes and Development
Volume14
Issue number5
StatePublished - Mar 1 2000
Externally publishedYes

Fingerprint

Catenins
Oncogenes
Proteins
Growth
Nude Mice
Transcriptional Activation
Agar
Intercellular Signaling Peptides and Proteins
Carcinogenesis
Fibroblasts
Kidney
Genes
Neoplasms

Keywords

  • β-catenin
  • Oncogene
  • WISP-1
  • Wnt-1

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

Cite this

Xu, L., Corcoran, R. B., Welsh, J. W., Pennica, D., & Levine, A. J. (2000). WISP-1 is a Wnt-1- and β-catenin-responsive oncogene. Genes and Development, 14(5), 585-595.

WISP-1 is a Wnt-1- and β-catenin-responsive oncogene. / Xu, Lifeng; Corcoran, Ryan B.; Welsh, James W.; Pennica, Diane; Levine, Arnold J.

In: Genes and Development, Vol. 14, No. 5, 01.03.2000, p. 585-595.

Research output: Contribution to journalArticle

Xu, L, Corcoran, RB, Welsh, JW, Pennica, D & Levine, AJ 2000, 'WISP-1 is a Wnt-1- and β-catenin-responsive oncogene', Genes and Development, vol. 14, no. 5, pp. 585-595.
Xu L, Corcoran RB, Welsh JW, Pennica D, Levine AJ. WISP-1 is a Wnt-1- and β-catenin-responsive oncogene. Genes and Development. 2000 Mar 1;14(5):585-595.
Xu, Lifeng ; Corcoran, Ryan B. ; Welsh, James W. ; Pennica, Diane ; Levine, Arnold J. / WISP-1 is a Wnt-1- and β-catenin-responsive oncogene. In: Genes and Development. 2000 ; Vol. 14, No. 5. pp. 585-595.
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