Widespread RNA editing dysregulation in brains from autistic individuals

Stephen S. Tran, Hyun Ik Jun, Jae Hoon Bahn, Adel Azghadi, Gokul Ramaswami, Eric L. Van Nostrand, Thai B. Nguyen, Yun Hua E. Hsiao, Changhoon Lee, Gabriel A. Pratt, Veronica Martinez-Cerdeno, Randi J Hagerman, Gene W. Yeo, Daniel H. Geschwind, Xinshu Xiao

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Transcriptomic analyses of postmortem brains have begun to elucidate molecular abnormalities in autism spectrum disorder (ASD). However, a crucial pathway involved in synaptic development, RNA editing, has not yet been studied on a genome-wide scale. Here we profiled global patterns of adenosine-to-inosine (A-to-I) editing in a large cohort of postmortem brains of people with ASD. We observed a global bias for hypoediting in ASD brains, which was shared across brain regions and involved many synaptic genes. We show that the Fragile X proteins FMRP and FXR1P interact with RNA-editing enzymes (ADAR proteins) and modulate A-to-I editing. Furthermore, we observed convergent patterns of RNA-editing alterations in ASD and Fragile X syndrome, establishing this as a molecular link between these related diseases. Our findings, which are corroborated across multiple data sets, including dup15q (genomic duplication of 15q11.2-13.1) cases associated with intellectual disability, highlight RNA-editing dysregulation in ASD and reveal new mechanisms underlying this disorder.

Original languageEnglish (US)
Pages (from-to)25-36
Number of pages12
JournalNature Neuroscience
Volume22
Issue number1
DOIs
StatePublished - Jan 1 2019

Fingerprint

RNA Editing
Brain
Inosine
Adenosine
Fragile X Mental Retardation Protein
Fragile X Syndrome
Intellectual Disability
Autism Spectrum Disorder
Genome
Enzymes
Genes
Proteins

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Tran, S. S., Jun, H. I., Bahn, J. H., Azghadi, A., Ramaswami, G., Van Nostrand, E. L., ... Xiao, X. (2019). Widespread RNA editing dysregulation in brains from autistic individuals. Nature Neuroscience, 22(1), 25-36. https://doi.org/10.1038/s41593-018-0287-x

Widespread RNA editing dysregulation in brains from autistic individuals. / Tran, Stephen S.; Jun, Hyun Ik; Bahn, Jae Hoon; Azghadi, Adel; Ramaswami, Gokul; Van Nostrand, Eric L.; Nguyen, Thai B.; Hsiao, Yun Hua E.; Lee, Changhoon; Pratt, Gabriel A.; Martinez-Cerdeno, Veronica; Hagerman, Randi J; Yeo, Gene W.; Geschwind, Daniel H.; Xiao, Xinshu.

In: Nature Neuroscience, Vol. 22, No. 1, 01.01.2019, p. 25-36.

Research output: Contribution to journalArticle

Tran, SS, Jun, HI, Bahn, JH, Azghadi, A, Ramaswami, G, Van Nostrand, EL, Nguyen, TB, Hsiao, YHE, Lee, C, Pratt, GA, Martinez-Cerdeno, V, Hagerman, RJ, Yeo, GW, Geschwind, DH & Xiao, X 2019, 'Widespread RNA editing dysregulation in brains from autistic individuals', Nature Neuroscience, vol. 22, no. 1, pp. 25-36. https://doi.org/10.1038/s41593-018-0287-x
Tran SS, Jun HI, Bahn JH, Azghadi A, Ramaswami G, Van Nostrand EL et al. Widespread RNA editing dysregulation in brains from autistic individuals. Nature Neuroscience. 2019 Jan 1;22(1):25-36. https://doi.org/10.1038/s41593-018-0287-x
Tran, Stephen S. ; Jun, Hyun Ik ; Bahn, Jae Hoon ; Azghadi, Adel ; Ramaswami, Gokul ; Van Nostrand, Eric L. ; Nguyen, Thai B. ; Hsiao, Yun Hua E. ; Lee, Changhoon ; Pratt, Gabriel A. ; Martinez-Cerdeno, Veronica ; Hagerman, Randi J ; Yeo, Gene W. ; Geschwind, Daniel H. ; Xiao, Xinshu. / Widespread RNA editing dysregulation in brains from autistic individuals. In: Nature Neuroscience. 2019 ; Vol. 22, No. 1. pp. 25-36.
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