Why primate models matter

Kimberley A. Phillips, Karen L. Bales, John P. Capitanio, Alan J Conley, Paul W. Czoty, Bert A. 't Hart, William D. Hopkins, Shiu Lok Hu, Lisa Miller, Michael A. Nader, Peter W. Nathanielsz, Jeffrey Rogers, Carol A. Shively, Mary Lou Voytko

Research output: Contribution to journalArticle

168 Citations (Scopus)

Abstract

Research involving nonhuman primates (NHPs) has played a vital role in many of the medical and scientific advances of the past century. NHPs are used because of their similarity to humans in physiology, neuroanatomy, reproduction, development, cognition, and social complexity-yet it is these very similarities that make the use of NHPs in biomedical research a considered decision. As primate researchers, we feel an obligation and responsibility to present the facts concerning why primates are used in various areas of biomedical research. Recent decisions in the United States, including the phasing out of chimpanzees in research by the National Institutes of Health and the pending closure of the New England Primate Research Center, illustrate to us the critical importance of conveying why continued research with primates is needed. Here, we review key areas in biomedicine where primate models have been, and continue to be, essential for advancing fundamental knowledge in biomedical and biological research. Am. J. Primatol. 76:801-827, 2014.

Original languageEnglish (US)
Pages (from-to)801-827
Number of pages27
JournalAmerican Journal of Primatology
Volume76
Issue number9
DOIs
StatePublished - 2014

Fingerprint

primate
Primates
animal models
biomedical research
human physiology
National Institutes of Health
New England region
cognition
Pan troglodytes
physiology
researchers

Keywords

  • Animal models
  • Nonhuman primates
  • Translational research

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Ecology, Evolution, Behavior and Systematics

Cite this

Phillips, K. A., Bales, K. L., Capitanio, J. P., Conley, A. J., Czoty, P. W., 't Hart, B. A., ... Voytko, M. L. (2014). Why primate models matter. American Journal of Primatology, 76(9), 801-827. https://doi.org/10.1002/ajp.22281

Why primate models matter. / Phillips, Kimberley A.; Bales, Karen L.; Capitanio, John P.; Conley, Alan J; Czoty, Paul W.; 't Hart, Bert A.; Hopkins, William D.; Hu, Shiu Lok; Miller, Lisa; Nader, Michael A.; Nathanielsz, Peter W.; Rogers, Jeffrey; Shively, Carol A.; Voytko, Mary Lou.

In: American Journal of Primatology, Vol. 76, No. 9, 2014, p. 801-827.

Research output: Contribution to journalArticle

Phillips, KA, Bales, KL, Capitanio, JP, Conley, AJ, Czoty, PW, 't Hart, BA, Hopkins, WD, Hu, SL, Miller, L, Nader, MA, Nathanielsz, PW, Rogers, J, Shively, CA & Voytko, ML 2014, 'Why primate models matter', American Journal of Primatology, vol. 76, no. 9, pp. 801-827. https://doi.org/10.1002/ajp.22281
Phillips KA, Bales KL, Capitanio JP, Conley AJ, Czoty PW, 't Hart BA et al. Why primate models matter. American Journal of Primatology. 2014;76(9):801-827. https://doi.org/10.1002/ajp.22281
Phillips, Kimberley A. ; Bales, Karen L. ; Capitanio, John P. ; Conley, Alan J ; Czoty, Paul W. ; 't Hart, Bert A. ; Hopkins, William D. ; Hu, Shiu Lok ; Miller, Lisa ; Nader, Michael A. ; Nathanielsz, Peter W. ; Rogers, Jeffrey ; Shively, Carol A. ; Voytko, Mary Lou. / Why primate models matter. In: American Journal of Primatology. 2014 ; Vol. 76, No. 9. pp. 801-827.
@article{1653567a0ccf4656beb1de45c667c764,
title = "Why primate models matter",
abstract = "Research involving nonhuman primates (NHPs) has played a vital role in many of the medical and scientific advances of the past century. NHPs are used because of their similarity to humans in physiology, neuroanatomy, reproduction, development, cognition, and social complexity-yet it is these very similarities that make the use of NHPs in biomedical research a considered decision. As primate researchers, we feel an obligation and responsibility to present the facts concerning why primates are used in various areas of biomedical research. Recent decisions in the United States, including the phasing out of chimpanzees in research by the National Institutes of Health and the pending closure of the New England Primate Research Center, illustrate to us the critical importance of conveying why continued research with primates is needed. Here, we review key areas in biomedicine where primate models have been, and continue to be, essential for advancing fundamental knowledge in biomedical and biological research. Am. J. Primatol. 76:801-827, 2014.",
keywords = "Animal models, Nonhuman primates, Translational research",
author = "Phillips, {Kimberley A.} and Bales, {Karen L.} and Capitanio, {John P.} and Conley, {Alan J} and Czoty, {Paul W.} and {'t Hart}, {Bert A.} and Hopkins, {William D.} and Hu, {Shiu Lok} and Lisa Miller and Nader, {Michael A.} and Nathanielsz, {Peter W.} and Jeffrey Rogers and Shively, {Carol A.} and Voytko, {Mary Lou}",
year = "2014",
doi = "10.1002/ajp.22281",
language = "English (US)",
volume = "76",
pages = "801--827",
journal = "American Journal of Primatology",
issn = "0275-2565",
publisher = "John Wiley and Sons Inc.",
number = "9",

}

TY - JOUR

T1 - Why primate models matter

AU - Phillips, Kimberley A.

AU - Bales, Karen L.

AU - Capitanio, John P.

AU - Conley, Alan J

AU - Czoty, Paul W.

AU - 't Hart, Bert A.

AU - Hopkins, William D.

AU - Hu, Shiu Lok

AU - Miller, Lisa

AU - Nader, Michael A.

AU - Nathanielsz, Peter W.

AU - Rogers, Jeffrey

AU - Shively, Carol A.

AU - Voytko, Mary Lou

PY - 2014

Y1 - 2014

N2 - Research involving nonhuman primates (NHPs) has played a vital role in many of the medical and scientific advances of the past century. NHPs are used because of their similarity to humans in physiology, neuroanatomy, reproduction, development, cognition, and social complexity-yet it is these very similarities that make the use of NHPs in biomedical research a considered decision. As primate researchers, we feel an obligation and responsibility to present the facts concerning why primates are used in various areas of biomedical research. Recent decisions in the United States, including the phasing out of chimpanzees in research by the National Institutes of Health and the pending closure of the New England Primate Research Center, illustrate to us the critical importance of conveying why continued research with primates is needed. Here, we review key areas in biomedicine where primate models have been, and continue to be, essential for advancing fundamental knowledge in biomedical and biological research. Am. J. Primatol. 76:801-827, 2014.

AB - Research involving nonhuman primates (NHPs) has played a vital role in many of the medical and scientific advances of the past century. NHPs are used because of their similarity to humans in physiology, neuroanatomy, reproduction, development, cognition, and social complexity-yet it is these very similarities that make the use of NHPs in biomedical research a considered decision. As primate researchers, we feel an obligation and responsibility to present the facts concerning why primates are used in various areas of biomedical research. Recent decisions in the United States, including the phasing out of chimpanzees in research by the National Institutes of Health and the pending closure of the New England Primate Research Center, illustrate to us the critical importance of conveying why continued research with primates is needed. Here, we review key areas in biomedicine where primate models have been, and continue to be, essential for advancing fundamental knowledge in biomedical and biological research. Am. J. Primatol. 76:801-827, 2014.

KW - Animal models

KW - Nonhuman primates

KW - Translational research

UR - http://www.scopus.com/inward/record.url?scp=84906324660&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84906324660&partnerID=8YFLogxK

U2 - 10.1002/ajp.22281

DO - 10.1002/ajp.22281

M3 - Article

C2 - 24723482

AN - SCOPUS:84906324660

VL - 76

SP - 801

EP - 827

JO - American Journal of Primatology

JF - American Journal of Primatology

SN - 0275-2565

IS - 9

ER -