Whorl pattern keratopathies in veterinary and human patients

Research output: Contribution to journalArticle

Abstract

The course travelled by corneal epithelial cells from their stem cell niche at the limbus toward the vertex of the cornea is normally not evident due to their transparency, but in certain conditions, the epithelial cells can be rendered visible to the clinician. In such cases, the pathway taken by epithelial cells can manifest as a whorl pattern described using a variety of terms including hurricane keratitis/keratopathy, vortex keratopathy, whorl keratopathy, cornea verticillata, and at times, named after causative agents as exemplified by amiodarone keratopathy. Here, we briefly discuss the terminology used and the spectrum of conditions that can result in keratopathies with whorl patterns in human patients. We review the manifestations of such patterns in veterinary patients and discuss the state of understanding of the underlying forces that create the whorl distribution of epithelial cells on the ocular surface.

Original languageEnglish (US)
Pages (from-to)661-667
Number of pages7
JournalVeterinary Ophthalmology
Volume21
Issue number6
DOIs
StatePublished - Nov 1 2018

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epithelial cells
Epithelial Cells
cornea
Cornea
Stem Cell Niche
Cyclonic Storms
keratitis
Amiodarone
Keratitis
hurricanes
terminology
Terminology
stem cells
niches
eyes

Keywords

  • cornea verticillata
  • corneal epithelium
  • hurricane keratopathy
  • pigmentation
  • vortex keratopathy
  • whorl pattern

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Whorl pattern keratopathies in veterinary and human patients. / Kim, Soohyun; Thomasy, Sara M; Ramsey, David; Zhao, Min; Mannis, Mark J; Murphy, Christopher J.

In: Veterinary Ophthalmology, Vol. 21, No. 6, 01.11.2018, p. 661-667.

Research output: Contribution to journalArticle

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