Whole-Cell cAMP and PKA Activity are Epiphenomena, Nanodomain Signaling Matters

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Novel targeted fluorescent biosensors provide key insights into very local nanodomains of cAMP and PKA activity, and how they respond differently to β-adrenergic activation in cardiac myocytes. This unique spatiotemporal detail in living cells is not available with biochemical measurements of total cellular cAMP and PKA, and provides unique physiological insights.

Original languageEnglish (US)
Pages (from-to)240-249
Number of pages10
JournalPhysiology (Bethesda, Md.)
Volume34
Issue number4
DOIs
StatePublished - Jul 1 2019

ASJC Scopus subject areas

  • Physiology

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