Whither or wither microbicides?

Robert M. Grant, Dean Hamer, Thomas Hope, Rowena Johnston, Joep Lange, Michael M. Lederman, Judy Lieberman, Chris J Miller, John P. Moore, Donald E. Mosier, Douglas D. Richman, Robert T. Schooley, Marty S. Springer, Ronald S. Veazey, Mark A. Wainberg

Research output: Contribution to journalArticle

114 Scopus citations


After disappointing results from all efficacy trials conducted to date, the field of microbicides research now faces substantial challenges. Poor coordination among interested parties and the choice of nonvalidated scientific targets for phase III studies have hampered progress and created mistrust about the use of microbicides as a method to prevent HIV-1 sexual transmission. Although new promising strategies are available, there will need to be serious reappraisals of how decisions are made to advance the next generations of candidates into clinical trials, and the use of appropriate animal models in this process will be critical.

Original languageEnglish (US)
Pages (from-to)532-534
Number of pages3
Issue number5888
StatePublished - Jul 25 2008


ASJC Scopus subject areas

  • General

Cite this

Grant, R. M., Hamer, D., Hope, T., Johnston, R., Lange, J., Lederman, M. M., Lieberman, J., Miller, C. J., Moore, J. P., Mosier, D. E., Richman, D. D., Schooley, R. T., Springer, M. S., Veazey, R. S., & Wainberg, M. A. (2008). Whither or wither microbicides? Science, 321(5888), 532-534. https://doi.org/10.1126/science.1160355