White matter volume and white/gray matter ratio in mammalian species as a consequence of the universal scaling of cortical folding

Bruno Mota, Sandra E. Dos Santos, Lissa Ventura-Antunes, Débora Jardim-Messeder, Kleber Neves, Rodrigo S. Kazu, Stephen C Noctor, Kelly Lambert, Mads F. Bertelsen, Paul R. Manger, Chet C. Sherwood, Jon H. Kaas, Suzana Herculano-Houzel

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Because the white matter of the cerebral cortex contains axons that connect distant neurons in the cortical gray matter, the relationship between the volumes of the 2 cortical compartments is key for information transmission in the brain. It has been suggested that the volume of the white matter scales universally as a function of the volume of the gray matter across mammalian species, as would be expected if a global principle of wiring minimization applied. Using a systematic analysis across several mammalian clades, here we show that the volume of the white matter does not scale universally with the volume of the gray matter across mammals and is not optimized for wiring minimization. Instead, the ratio between volumes of gray and white matter is universally predicted by the same equation that predicts the degree of folding of the cerebral cortex, given the clade-specific scaling of cortical thickness, such that the volume of the gray matter (or the ratio of gray to total cortical volumes) divided by the square root of cortical thickness is a universal function of total cortical volume, regardless of the number of cortical neurons. Thus, the very mechanism that we propose to generate cortical folding also results in compactness of the white matter to a predictable degree across a wide variety of mammalian species.

Original languageEnglish (US)
Pages (from-to)15253-15261
Number of pages9
JournalProceedings of the National Academy of Sciences of the United States of America
Volume116
Issue number30
DOIs
StatePublished - Jul 23 2019

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Cerebral Cortex
Neurons
Axons
Mammals
White Matter
Gray Matter
Brain

Keywords

  • Brain size
  • Cortical folding
  • Evolution
  • Scaling
  • White matter

ASJC Scopus subject areas

  • General

Cite this

White matter volume and white/gray matter ratio in mammalian species as a consequence of the universal scaling of cortical folding. / Mota, Bruno; Dos Santos, Sandra E.; Ventura-Antunes, Lissa; Jardim-Messeder, Débora; Neves, Kleber; Kazu, Rodrigo S.; Noctor, Stephen C; Lambert, Kelly; Bertelsen, Mads F.; Manger, Paul R.; Sherwood, Chet C.; Kaas, Jon H.; Herculano-Houzel, Suzana.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 116, No. 30, 23.07.2019, p. 15253-15261.

Research output: Contribution to journalArticle

Mota, B, Dos Santos, SE, Ventura-Antunes, L, Jardim-Messeder, D, Neves, K, Kazu, RS, Noctor, SC, Lambert, K, Bertelsen, MF, Manger, PR, Sherwood, CC, Kaas, JH & Herculano-Houzel, S 2019, 'White matter volume and white/gray matter ratio in mammalian species as a consequence of the universal scaling of cortical folding', Proceedings of the National Academy of Sciences of the United States of America, vol. 116, no. 30, pp. 15253-15261. https://doi.org/10.1073/pnas.1716956116
Mota, Bruno ; Dos Santos, Sandra E. ; Ventura-Antunes, Lissa ; Jardim-Messeder, Débora ; Neves, Kleber ; Kazu, Rodrigo S. ; Noctor, Stephen C ; Lambert, Kelly ; Bertelsen, Mads F. ; Manger, Paul R. ; Sherwood, Chet C. ; Kaas, Jon H. ; Herculano-Houzel, Suzana. / White matter volume and white/gray matter ratio in mammalian species as a consequence of the universal scaling of cortical folding. In: Proceedings of the National Academy of Sciences of the United States of America. 2019 ; Vol. 116, No. 30. pp. 15253-15261.
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