White matter stimulation for the treatment of epilepsy

Fady Girgis, Jonathan P. Miller

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Electrical stimulation in the treatment of epilepsy has been tried in numerous forms and with a variety of targets. Some of these, such as anterior thalamic stimulation, responsive cortical stimulation, and vagal nerve stimulation, have shown promise. A relatively novel concept, that of white matter stimulation, offers a different mechanism in that a small population of stimulated axons can transmit current to a large population of epileptogenic neurons. In theory, this allows for the modulation of seizure circuits and neural networks using lower stimulation volumes. Although clinical data is currently sparse, we review the relevant studies pertaining to white matter stimulation in epilepsy thus far, and offer explanations as to its effects, potential advantages, and utility.

Original languageEnglish (US)
Pages (from-to)28-31
Number of pages4
StatePublished - Apr 1 2016
Externally publishedYes


  • Epilepsy
  • Neuromodulation
  • Neurostimulation
  • White matter stimulation

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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