TY - JOUR
T1 - White matter stimulation for the treatment of epilepsy
AU - Girgis, Fady
AU - Miller, Jonathan P.
PY - 2016/4/1
Y1 - 2016/4/1
N2 - Electrical stimulation in the treatment of epilepsy has been tried in numerous forms and with a variety of targets. Some of these, such as anterior thalamic stimulation, responsive cortical stimulation, and vagal nerve stimulation, have shown promise. A relatively novel concept, that of white matter stimulation, offers a different mechanism in that a small population of stimulated axons can transmit current to a large population of epileptogenic neurons. In theory, this allows for the modulation of seizure circuits and neural networks using lower stimulation volumes. Although clinical data is currently sparse, we review the relevant studies pertaining to white matter stimulation in epilepsy thus far, and offer explanations as to its effects, potential advantages, and utility.
AB - Electrical stimulation in the treatment of epilepsy has been tried in numerous forms and with a variety of targets. Some of these, such as anterior thalamic stimulation, responsive cortical stimulation, and vagal nerve stimulation, have shown promise. A relatively novel concept, that of white matter stimulation, offers a different mechanism in that a small population of stimulated axons can transmit current to a large population of epileptogenic neurons. In theory, this allows for the modulation of seizure circuits and neural networks using lower stimulation volumes. Although clinical data is currently sparse, we review the relevant studies pertaining to white matter stimulation in epilepsy thus far, and offer explanations as to its effects, potential advantages, and utility.
KW - Epilepsy
KW - Neuromodulation
KW - Neurostimulation
KW - White matter stimulation
UR - http://www.scopus.com/inward/record.url?scp=84959321707&partnerID=8YFLogxK
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U2 - 10.1016/j.seizure.2016.02.004
DO - 10.1016/j.seizure.2016.02.004
M3 - Article
C2 - 26926734
AN - SCOPUS:84959321707
VL - 37
SP - 28
EP - 31
JO - Seizure : the journal of the British Epilepsy Association
JF - Seizure : the journal of the British Epilepsy Association
SN - 1059-1311
ER -