Abstract
The goal of this study was to examine the relationship between subcortical vascular disease and brain atrophy in patients with Alzheimer's disease (AD) and mixed dementia (i.e., AD and subcortical vascular disease together). MRI was performed on 77 cognitively normal (CN) subjects, 50 AD and 13 mixed dementia patients. Subcortical vascular disease was determined by white matter hyperintensities (WMH) volume and presence of subcortical lacunes. Brain atrophy was measured using total brain cortical gray matter (CGM), entorhinal cortex (ERC) and hippocampal volumes. CGM volume, but not ERC or hippocampal volume was inversely related to WMH volume in patients and controls. In contrast, no relationship was detected between CGM, ERC, or hippocampal volumes and subcortical lacunes. Furthermore, no interaction was found between WMH and diagnosis on cortical atrophy, implying that WMH affect cortical atrophy indifferently of group. These results suggest that subcortical vascular disease, manifested as WMH, may affect cortical atrophy more than ERC and hippocampal atrophy. Further, AD pathology and subcortical vascular disease may independently affect cortical atrophy.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 553-559 |
| Number of pages | 7 |
| Journal | Neurobiology of Aging |
| Volume | 26 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 2005 |
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Keywords
- Alzheimer's disease
- Subcortical lacunes
- Subcortical vascular disease
- The cortex
- The entorhinal cortex
- The hippocampus
- White matter hyperintensities
ASJC Scopus subject areas
- Clinical Neurology
- Biological Psychiatry
- Developmental Neuroscience
- Neurology
- Psychology(all)
Cite this
White matter lesions are associated with cortical atrophy more than entorhinal and hippocampal atrophy. / Du, An Tao; Schuff, Norbert; Chao, Linda L.; Kornak, John; Ezekiel, Frank; Jagust, William J.; Kramer, Joel H.; Reed, Bruce R; Miller, Bruce L.; Norman, David; Chui, Helena C.; Weiner, Michael W.
In: Neurobiology of Aging, Vol. 26, No. 4, 04.2005, p. 553-559.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - White matter lesions are associated with cortical atrophy more than entorhinal and hippocampal atrophy
AU - Du, An Tao
AU - Schuff, Norbert
AU - Chao, Linda L.
AU - Kornak, John
AU - Ezekiel, Frank
AU - Jagust, William J.
AU - Kramer, Joel H.
AU - Reed, Bruce R
AU - Miller, Bruce L.
AU - Norman, David
AU - Chui, Helena C.
AU - Weiner, Michael W.
PY - 2005/4
Y1 - 2005/4
N2 - The goal of this study was to examine the relationship between subcortical vascular disease and brain atrophy in patients with Alzheimer's disease (AD) and mixed dementia (i.e., AD and subcortical vascular disease together). MRI was performed on 77 cognitively normal (CN) subjects, 50 AD and 13 mixed dementia patients. Subcortical vascular disease was determined by white matter hyperintensities (WMH) volume and presence of subcortical lacunes. Brain atrophy was measured using total brain cortical gray matter (CGM), entorhinal cortex (ERC) and hippocampal volumes. CGM volume, but not ERC or hippocampal volume was inversely related to WMH volume in patients and controls. In contrast, no relationship was detected between CGM, ERC, or hippocampal volumes and subcortical lacunes. Furthermore, no interaction was found between WMH and diagnosis on cortical atrophy, implying that WMH affect cortical atrophy indifferently of group. These results suggest that subcortical vascular disease, manifested as WMH, may affect cortical atrophy more than ERC and hippocampal atrophy. Further, AD pathology and subcortical vascular disease may independently affect cortical atrophy.
AB - The goal of this study was to examine the relationship between subcortical vascular disease and brain atrophy in patients with Alzheimer's disease (AD) and mixed dementia (i.e., AD and subcortical vascular disease together). MRI was performed on 77 cognitively normal (CN) subjects, 50 AD and 13 mixed dementia patients. Subcortical vascular disease was determined by white matter hyperintensities (WMH) volume and presence of subcortical lacunes. Brain atrophy was measured using total brain cortical gray matter (CGM), entorhinal cortex (ERC) and hippocampal volumes. CGM volume, but not ERC or hippocampal volume was inversely related to WMH volume in patients and controls. In contrast, no relationship was detected between CGM, ERC, or hippocampal volumes and subcortical lacunes. Furthermore, no interaction was found between WMH and diagnosis on cortical atrophy, implying that WMH affect cortical atrophy indifferently of group. These results suggest that subcortical vascular disease, manifested as WMH, may affect cortical atrophy more than ERC and hippocampal atrophy. Further, AD pathology and subcortical vascular disease may independently affect cortical atrophy.
KW - Alzheimer's disease
KW - Subcortical lacunes
KW - Subcortical vascular disease
KW - The cortex
KW - The entorhinal cortex
KW - The hippocampus
KW - White matter hyperintensities
UR - http://www.scopus.com/inward/record.url?scp=19944426233&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=19944426233&partnerID=8YFLogxK
U2 - 10.1016/j.neurobiolaging.2004.05.002
DO - 10.1016/j.neurobiolaging.2004.05.002
M3 - Article
C2 - 15653183
AN - SCOPUS:19944426233
VL - 26
SP - 553
EP - 559
JO - Neurobiology of Aging
JF - Neurobiology of Aging
SN - 0197-4580
IS - 4
ER -