White matter lesions are associated with cortical atrophy more than entorhinal and hippocampal atrophy

An Tao Du, Norbert Schuff, Linda L. Chao, John Kornak, Frank Ezekiel, William J. Jagust, Joel H. Kramer, Bruce R Reed, Bruce L. Miller, David Norman, Helena C. Chui, Michael W. Weiner

Research output: Contribution to journalArticle

85 Citations (Scopus)

Abstract

The goal of this study was to examine the relationship between subcortical vascular disease and brain atrophy in patients with Alzheimer's disease (AD) and mixed dementia (i.e., AD and subcortical vascular disease together). MRI was performed on 77 cognitively normal (CN) subjects, 50 AD and 13 mixed dementia patients. Subcortical vascular disease was determined by white matter hyperintensities (WMH) volume and presence of subcortical lacunes. Brain atrophy was measured using total brain cortical gray matter (CGM), entorhinal cortex (ERC) and hippocampal volumes. CGM volume, but not ERC or hippocampal volume was inversely related to WMH volume in patients and controls. In contrast, no relationship was detected between CGM, ERC, or hippocampal volumes and subcortical lacunes. Furthermore, no interaction was found between WMH and diagnosis on cortical atrophy, implying that WMH affect cortical atrophy indifferently of group. These results suggest that subcortical vascular disease, manifested as WMH, may affect cortical atrophy more than ERC and hippocampal atrophy. Further, AD pathology and subcortical vascular disease may independently affect cortical atrophy.

Original languageEnglish (US)
Pages (from-to)553-559
Number of pages7
JournalNeurobiology of Aging
Volume26
Issue number4
DOIs
StatePublished - Apr 2005

Fingerprint

Atrophy
Vascular Diseases
Entorhinal Cortex
Alzheimer Disease
Dementia
Brain
White Matter
Pathology
Gray Matter

Keywords

  • Alzheimer's disease
  • Subcortical lacunes
  • Subcortical vascular disease
  • The cortex
  • The entorhinal cortex
  • The hippocampus
  • White matter hyperintensities

ASJC Scopus subject areas

  • Clinical Neurology
  • Biological Psychiatry
  • Developmental Neuroscience
  • Neurology
  • Psychology(all)

Cite this

Du, A. T., Schuff, N., Chao, L. L., Kornak, J., Ezekiel, F., Jagust, W. J., ... Weiner, M. W. (2005). White matter lesions are associated with cortical atrophy more than entorhinal and hippocampal atrophy. Neurobiology of Aging, 26(4), 553-559. https://doi.org/10.1016/j.neurobiolaging.2004.05.002

White matter lesions are associated with cortical atrophy more than entorhinal and hippocampal atrophy. / Du, An Tao; Schuff, Norbert; Chao, Linda L.; Kornak, John; Ezekiel, Frank; Jagust, William J.; Kramer, Joel H.; Reed, Bruce R; Miller, Bruce L.; Norman, David; Chui, Helena C.; Weiner, Michael W.

In: Neurobiology of Aging, Vol. 26, No. 4, 04.2005, p. 553-559.

Research output: Contribution to journalArticle

Du, AT, Schuff, N, Chao, LL, Kornak, J, Ezekiel, F, Jagust, WJ, Kramer, JH, Reed, BR, Miller, BL, Norman, D, Chui, HC & Weiner, MW 2005, 'White matter lesions are associated with cortical atrophy more than entorhinal and hippocampal atrophy', Neurobiology of Aging, vol. 26, no. 4, pp. 553-559. https://doi.org/10.1016/j.neurobiolaging.2004.05.002
Du, An Tao ; Schuff, Norbert ; Chao, Linda L. ; Kornak, John ; Ezekiel, Frank ; Jagust, William J. ; Kramer, Joel H. ; Reed, Bruce R ; Miller, Bruce L. ; Norman, David ; Chui, Helena C. ; Weiner, Michael W. / White matter lesions are associated with cortical atrophy more than entorhinal and hippocampal atrophy. In: Neurobiology of Aging. 2005 ; Vol. 26, No. 4. pp. 553-559.
@article{07c2457b9c8349d482de7ca5ed77f661,
title = "White matter lesions are associated with cortical atrophy more than entorhinal and hippocampal atrophy",
abstract = "The goal of this study was to examine the relationship between subcortical vascular disease and brain atrophy in patients with Alzheimer's disease (AD) and mixed dementia (i.e., AD and subcortical vascular disease together). MRI was performed on 77 cognitively normal (CN) subjects, 50 AD and 13 mixed dementia patients. Subcortical vascular disease was determined by white matter hyperintensities (WMH) volume and presence of subcortical lacunes. Brain atrophy was measured using total brain cortical gray matter (CGM), entorhinal cortex (ERC) and hippocampal volumes. CGM volume, but not ERC or hippocampal volume was inversely related to WMH volume in patients and controls. In contrast, no relationship was detected between CGM, ERC, or hippocampal volumes and subcortical lacunes. Furthermore, no interaction was found between WMH and diagnosis on cortical atrophy, implying that WMH affect cortical atrophy indifferently of group. These results suggest that subcortical vascular disease, manifested as WMH, may affect cortical atrophy more than ERC and hippocampal atrophy. Further, AD pathology and subcortical vascular disease may independently affect cortical atrophy.",
keywords = "Alzheimer's disease, Subcortical lacunes, Subcortical vascular disease, The cortex, The entorhinal cortex, The hippocampus, White matter hyperintensities",
author = "Du, {An Tao} and Norbert Schuff and Chao, {Linda L.} and John Kornak and Frank Ezekiel and Jagust, {William J.} and Kramer, {Joel H.} and Reed, {Bruce R} and Miller, {Bruce L.} and David Norman and Chui, {Helena C.} and Weiner, {Michael W.}",
year = "2005",
month = "4",
doi = "10.1016/j.neurobiolaging.2004.05.002",
language = "English (US)",
volume = "26",
pages = "553--559",
journal = "Neurobiology of Aging",
issn = "0197-4580",
publisher = "Elsevier Inc.",
number = "4",

}

TY - JOUR

T1 - White matter lesions are associated with cortical atrophy more than entorhinal and hippocampal atrophy

AU - Du, An Tao

AU - Schuff, Norbert

AU - Chao, Linda L.

AU - Kornak, John

AU - Ezekiel, Frank

AU - Jagust, William J.

AU - Kramer, Joel H.

AU - Reed, Bruce R

AU - Miller, Bruce L.

AU - Norman, David

AU - Chui, Helena C.

AU - Weiner, Michael W.

PY - 2005/4

Y1 - 2005/4

N2 - The goal of this study was to examine the relationship between subcortical vascular disease and brain atrophy in patients with Alzheimer's disease (AD) and mixed dementia (i.e., AD and subcortical vascular disease together). MRI was performed on 77 cognitively normal (CN) subjects, 50 AD and 13 mixed dementia patients. Subcortical vascular disease was determined by white matter hyperintensities (WMH) volume and presence of subcortical lacunes. Brain atrophy was measured using total brain cortical gray matter (CGM), entorhinal cortex (ERC) and hippocampal volumes. CGM volume, but not ERC or hippocampal volume was inversely related to WMH volume in patients and controls. In contrast, no relationship was detected between CGM, ERC, or hippocampal volumes and subcortical lacunes. Furthermore, no interaction was found between WMH and diagnosis on cortical atrophy, implying that WMH affect cortical atrophy indifferently of group. These results suggest that subcortical vascular disease, manifested as WMH, may affect cortical atrophy more than ERC and hippocampal atrophy. Further, AD pathology and subcortical vascular disease may independently affect cortical atrophy.

AB - The goal of this study was to examine the relationship between subcortical vascular disease and brain atrophy in patients with Alzheimer's disease (AD) and mixed dementia (i.e., AD and subcortical vascular disease together). MRI was performed on 77 cognitively normal (CN) subjects, 50 AD and 13 mixed dementia patients. Subcortical vascular disease was determined by white matter hyperintensities (WMH) volume and presence of subcortical lacunes. Brain atrophy was measured using total brain cortical gray matter (CGM), entorhinal cortex (ERC) and hippocampal volumes. CGM volume, but not ERC or hippocampal volume was inversely related to WMH volume in patients and controls. In contrast, no relationship was detected between CGM, ERC, or hippocampal volumes and subcortical lacunes. Furthermore, no interaction was found between WMH and diagnosis on cortical atrophy, implying that WMH affect cortical atrophy indifferently of group. These results suggest that subcortical vascular disease, manifested as WMH, may affect cortical atrophy more than ERC and hippocampal atrophy. Further, AD pathology and subcortical vascular disease may independently affect cortical atrophy.

KW - Alzheimer's disease

KW - Subcortical lacunes

KW - Subcortical vascular disease

KW - The cortex

KW - The entorhinal cortex

KW - The hippocampus

KW - White matter hyperintensities

UR - http://www.scopus.com/inward/record.url?scp=19944426233&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=19944426233&partnerID=8YFLogxK

U2 - 10.1016/j.neurobiolaging.2004.05.002

DO - 10.1016/j.neurobiolaging.2004.05.002

M3 - Article

C2 - 15653183

AN - SCOPUS:19944426233

VL - 26

SP - 553

EP - 559

JO - Neurobiology of Aging

JF - Neurobiology of Aging

SN - 0197-4580

IS - 4

ER -