White matter lesions are associated with cortical atrophy more than entorhinal and hippocampal atrophy

An Tao Du; Norbert Schuff; Linda L. Chao; John Kornak; Frank Ezekiel; William J. Jagust; Joel H. Kramer; Bruce R Reed; Bruce L. Miller; David Norman; Helena C. Chui; Michael W. Weiner

doi:10.1016/j.neurobiolaging.2004.05.002

White matter lesions are associated with cortical atrophy more than entorhinal and hippocampal atrophy

An Tao Du, Norbert Schuff, Linda L. Chao, John Kornak, Frank Ezekiel, William J. Jagust, Joel H. Kramer, Bruce R Reed, Bruce L. Miller, David Norman, Helena C. Chui, Michael W. Weiner

Neurology

Research output: Contribution to journal › Article

85 Scopus citations

Abstract

The goal of this study was to examine the relationship between subcortical vascular disease and brain atrophy in patients with Alzheimer's disease (AD) and mixed dementia (i.e., AD and subcortical vascular disease together). MRI was performed on 77 cognitively normal (CN) subjects, 50 AD and 13 mixed dementia patients. Subcortical vascular disease was determined by white matter hyperintensities (WMH) volume and presence of subcortical lacunes. Brain atrophy was measured using total brain cortical gray matter (CGM), entorhinal cortex (ERC) and hippocampal volumes. CGM volume, but not ERC or hippocampal volume was inversely related to WMH volume in patients and controls. In contrast, no relationship was detected between CGM, ERC, or hippocampal volumes and subcortical lacunes. Furthermore, no interaction was found between WMH and diagnosis on cortical atrophy, implying that WMH affect cortical atrophy indifferently of group. These results suggest that subcortical vascular disease, manifested as WMH, may affect cortical atrophy more than ERC and hippocampal atrophy. Further, AD pathology and subcortical vascular disease may independently affect cortical atrophy.

Original language	English (US)
Pages (from-to)	553-559
Number of pages	7
Journal	Neurobiology of Aging
Volume	26
Issue number	4
DOIs	https://doi.org/10.1016/j.neurobiolaging.2004.05.002
State	Published - Apr 2005

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Keywords

Alzheimer's disease
Subcortical lacunes
Subcortical vascular disease
The cortex
The entorhinal cortex
The hippocampus
White matter hyperintensities

ASJC Scopus subject areas

Clinical Neurology
Biological Psychiatry
Developmental Neuroscience
Neurology
Psychology(all)

Cite this

Du, A. T., Schuff, N., Chao, L. L., Kornak, J., Ezekiel, F., Jagust, W. J., Kramer, J. H., Reed, B. R., Miller, B. L., Norman, D., Chui, H. C., & Weiner, M. W. (2005). White matter lesions are associated with cortical atrophy more than entorhinal and hippocampal atrophy. Neurobiology of Aging, 26(4), 553-559. https://doi.org/10.1016/j.neurobiolaging.2004.05.002

White matter lesions are associated with cortical atrophy more than entorhinal and hippocampal atrophy. / Du, An Tao; Schuff, Norbert; Chao, Linda L.; Kornak, John; Ezekiel, Frank; Jagust, William J.; Kramer, Joel H.; Reed, Bruce R; Miller, Bruce L.; Norman, David; Chui, Helena C.; Weiner, Michael W.

In: Neurobiology of Aging, Vol. 26, No. 4, 04.2005, p. 553-559.

Research output: Contribution to journal › Article

Du, An Tao ; Schuff, Norbert ; Chao, Linda L. ; Kornak, John ; Ezekiel, Frank ; Jagust, William J. ; Kramer, Joel H. ; Reed, Bruce R ; Miller, Bruce L. ; Norman, David ; Chui, Helena C. ; Weiner, Michael W. / White matter lesions are associated with cortical atrophy more than entorhinal and hippocampal atrophy. In: Neurobiology of Aging. 2005 ; Vol. 26, No. 4. pp. 553-559.

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10.1016/j.neurobiolaging.2004.05.002