White matter hyperintensities in dementia of Alzheimer's type and in healthy subjects without cerebrovascular risk factors. A magnetic resonance imaging study

W. E. Kozachuk, Charles DeCarli, M. B. Schapiro, E. E. Wagner, S. I. Rapoport, B. Horwitz

Research output: Contribution to journalArticle

120 Citations (Scopus)

Abstract

T2-weighted (0.5 T) magnetic resonance images were used to study the prevalence of subcortical white matter hyperintensities (WMHIs) in 22 patients with dementia of Alzheimer's type (DAT), 20 age-matched older healthy control subjects, and 10 younger healthy control subjects. Exclusionary criteria for all groups included cerebrovascular risk factors. All subjects had Hachinski Ischemic Index scores of less than 2 and computed tomographic scans showing no infarct. The WMHIs were classified as periventricular WMHIs or deep WMHIs and graded 0 through 3 (0 indicated absent, and 3, severe). For the group with DAT and older control subjects, periventricular WMHIs and deep WMHIs were graded 2 or 3 in fewer than 17% and 27% of subjects, respectively, whereas in the younger control subjects, all ratings were grade 1 or less. Serum cholesterol and systolic blood pressure values, although within the normal range, were elevated significantly in older control subjects when compared with those in younger control subjects. No significant differences in WMHI ratings, blood pressure, cholesterol, or triglyceride levels were found between patients with DAT and age-matched control subjects. Systolic blood pressure levels correlated with the severity of periventricular WMHIs only in older control subjects. Age correlated with periventricular WMHIs and deep WMHIs within both the older control subjects and the patients with DAT. There was no significant correlation between WMHIs and the severity of dementia in the group with DAT. These results suggest that, in subjects screened for cerebrovascular risk factors. WMHIs are rare and occur with identical frequency in patients with DAT as in age-matched healthy control subjects. Furthermore, cognitive decline does not correlate with the severity of WMHIs in patients with DAT without cerebrovascular risk factors.

Original languageEnglish (US)
Pages (from-to)1306-1310
Number of pages5
JournalArchives of Neurology
Volume47
Issue number12
StatePublished - 1990
Externally publishedYes

Fingerprint

Healthy Volunteers
Alzheimer Disease
Magnetic Resonance Imaging
Blood Pressure
White Matter
Dementia
Risk Factors
Alzheimer
Cholesterol
Reference Values
Triglycerides
Magnetic Resonance Spectroscopy
Cross-Sectional Studies

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

White matter hyperintensities in dementia of Alzheimer's type and in healthy subjects without cerebrovascular risk factors. A magnetic resonance imaging study. / Kozachuk, W. E.; DeCarli, Charles; Schapiro, M. B.; Wagner, E. E.; Rapoport, S. I.; Horwitz, B.

In: Archives of Neurology, Vol. 47, No. 12, 1990, p. 1306-1310.

Research output: Contribution to journalArticle

@article{3e32ca46254e4673bab9300a9eadd99a,
title = "White matter hyperintensities in dementia of Alzheimer's type and in healthy subjects without cerebrovascular risk factors. A magnetic resonance imaging study",
abstract = "T2-weighted (0.5 T) magnetic resonance images were used to study the prevalence of subcortical white matter hyperintensities (WMHIs) in 22 patients with dementia of Alzheimer's type (DAT), 20 age-matched older healthy control subjects, and 10 younger healthy control subjects. Exclusionary criteria for all groups included cerebrovascular risk factors. All subjects had Hachinski Ischemic Index scores of less than 2 and computed tomographic scans showing no infarct. The WMHIs were classified as periventricular WMHIs or deep WMHIs and graded 0 through 3 (0 indicated absent, and 3, severe). For the group with DAT and older control subjects, periventricular WMHIs and deep WMHIs were graded 2 or 3 in fewer than 17{\%} and 27{\%} of subjects, respectively, whereas in the younger control subjects, all ratings were grade 1 or less. Serum cholesterol and systolic blood pressure values, although within the normal range, were elevated significantly in older control subjects when compared with those in younger control subjects. No significant differences in WMHI ratings, blood pressure, cholesterol, or triglyceride levels were found between patients with DAT and age-matched control subjects. Systolic blood pressure levels correlated with the severity of periventricular WMHIs only in older control subjects. Age correlated with periventricular WMHIs and deep WMHIs within both the older control subjects and the patients with DAT. There was no significant correlation between WMHIs and the severity of dementia in the group with DAT. These results suggest that, in subjects screened for cerebrovascular risk factors. WMHIs are rare and occur with identical frequency in patients with DAT as in age-matched healthy control subjects. Furthermore, cognitive decline does not correlate with the severity of WMHIs in patients with DAT without cerebrovascular risk factors.",
author = "Kozachuk, {W. E.} and Charles DeCarli and Schapiro, {M. B.} and Wagner, {E. E.} and Rapoport, {S. I.} and B. Horwitz",
year = "1990",
language = "English (US)",
volume = "47",
pages = "1306--1310",
journal = "Archives of Neurology",
issn = "0003-9942",
publisher = "American Medical Association",
number = "12",

}

TY - JOUR

T1 - White matter hyperintensities in dementia of Alzheimer's type and in healthy subjects without cerebrovascular risk factors. A magnetic resonance imaging study

AU - Kozachuk, W. E.

AU - DeCarli, Charles

AU - Schapiro, M. B.

AU - Wagner, E. E.

AU - Rapoport, S. I.

AU - Horwitz, B.

PY - 1990

Y1 - 1990

N2 - T2-weighted (0.5 T) magnetic resonance images were used to study the prevalence of subcortical white matter hyperintensities (WMHIs) in 22 patients with dementia of Alzheimer's type (DAT), 20 age-matched older healthy control subjects, and 10 younger healthy control subjects. Exclusionary criteria for all groups included cerebrovascular risk factors. All subjects had Hachinski Ischemic Index scores of less than 2 and computed tomographic scans showing no infarct. The WMHIs were classified as periventricular WMHIs or deep WMHIs and graded 0 through 3 (0 indicated absent, and 3, severe). For the group with DAT and older control subjects, periventricular WMHIs and deep WMHIs were graded 2 or 3 in fewer than 17% and 27% of subjects, respectively, whereas in the younger control subjects, all ratings were grade 1 or less. Serum cholesterol and systolic blood pressure values, although within the normal range, were elevated significantly in older control subjects when compared with those in younger control subjects. No significant differences in WMHI ratings, blood pressure, cholesterol, or triglyceride levels were found between patients with DAT and age-matched control subjects. Systolic blood pressure levels correlated with the severity of periventricular WMHIs only in older control subjects. Age correlated with periventricular WMHIs and deep WMHIs within both the older control subjects and the patients with DAT. There was no significant correlation between WMHIs and the severity of dementia in the group with DAT. These results suggest that, in subjects screened for cerebrovascular risk factors. WMHIs are rare and occur with identical frequency in patients with DAT as in age-matched healthy control subjects. Furthermore, cognitive decline does not correlate with the severity of WMHIs in patients with DAT without cerebrovascular risk factors.

AB - T2-weighted (0.5 T) magnetic resonance images were used to study the prevalence of subcortical white matter hyperintensities (WMHIs) in 22 patients with dementia of Alzheimer's type (DAT), 20 age-matched older healthy control subjects, and 10 younger healthy control subjects. Exclusionary criteria for all groups included cerebrovascular risk factors. All subjects had Hachinski Ischemic Index scores of less than 2 and computed tomographic scans showing no infarct. The WMHIs were classified as periventricular WMHIs or deep WMHIs and graded 0 through 3 (0 indicated absent, and 3, severe). For the group with DAT and older control subjects, periventricular WMHIs and deep WMHIs were graded 2 or 3 in fewer than 17% and 27% of subjects, respectively, whereas in the younger control subjects, all ratings were grade 1 or less. Serum cholesterol and systolic blood pressure values, although within the normal range, were elevated significantly in older control subjects when compared with those in younger control subjects. No significant differences in WMHI ratings, blood pressure, cholesterol, or triglyceride levels were found between patients with DAT and age-matched control subjects. Systolic blood pressure levels correlated with the severity of periventricular WMHIs only in older control subjects. Age correlated with periventricular WMHIs and deep WMHIs within both the older control subjects and the patients with DAT. There was no significant correlation between WMHIs and the severity of dementia in the group with DAT. These results suggest that, in subjects screened for cerebrovascular risk factors. WMHIs are rare and occur with identical frequency in patients with DAT as in age-matched healthy control subjects. Furthermore, cognitive decline does not correlate with the severity of WMHIs in patients with DAT without cerebrovascular risk factors.

UR - http://www.scopus.com/inward/record.url?scp=0025667243&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025667243&partnerID=8YFLogxK

M3 - Article

C2 - 2252447

AN - SCOPUS:0025667243

VL - 47

SP - 1306

EP - 1310

JO - Archives of Neurology

JF - Archives of Neurology

SN - 0003-9942

IS - 12

ER -