White Matter Hyperintensities in Aging and Dementia

Adriane Mayda, Mitsuhiro Yoshita, Charles DeCarli

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


Both advancing age and cognitive impairment are associated with increased prevalence of various brain diseases, with Alzheimer's disease (AD) and cerebrovascular disease (CVD) being the most common. Abnormalities of cerebral white matter commonly seen on a magnetic resonance image (MRI) as white matter hyperintensities (WMH) are non-specific, but are increased with aging, CVD, and as a possible consequence of AD. In this chapter, we review current scientific evidence regarding the impact of white matter changes, particularly WMH, on cognition with aging and in the setting of cognitive impairment syndromes such as mild cognitive impairment (MCI) and AD.

Original languageEnglish (US)
Title of host publicationImaging the Aging Brain
PublisherOxford University Press
ISBN (Print)9780199864836, 9780195328875
StatePublished - Feb 1 2010


  • Aging
  • Alzheimer's disease
  • Cerebrovascular disease
  • MCI and MRI

ASJC Scopus subject areas

  • Neuroscience(all)


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