White Matter Hyperintensities in Aging and Dementia

Adriane Mayda, Mitsuhiro Yoshita, Charles DeCarli

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Both advancing age and cognitive impairment are associated with increased prevalence of various brain diseases, with Alzheimer's disease (AD) and cerebrovascular disease (CVD) being the most common. Abnormalities of cerebral white matter commonly seen on a magnetic resonance image (MRI) as white matter hyperintensities (WMH) are non-specific, but are increased with aging, CVD, and as a possible consequence of AD. In this chapter, we review current scientific evidence regarding the impact of white matter changes, particularly WMH, on cognition with aging and in the setting of cognitive impairment syndromes such as mild cognitive impairment (MCI) and AD.

Original languageEnglish (US)
Title of host publicationImaging the Aging Brain
PublisherOxford University Press
ISBN (Print)9780199864836, 9780195328875
DOIs
StatePublished - Feb 1 2010

Fingerprint

Dementia
Cerebrovascular Disorders
Alzheimer Disease
Brain Diseases
Cognition
Magnetic Resonance Spectroscopy
White Matter
Cognitive Dysfunction

Keywords

  • Aging
  • Alzheimer's disease
  • Cerebrovascular disease
  • MCI and MRI

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Mayda, A., Yoshita, M., & DeCarli, C. (2010). White Matter Hyperintensities in Aging and Dementia. In Imaging the Aging Brain Oxford University Press. https://doi.org/10.1093/acprof:oso/9780195328875.003.0017

White Matter Hyperintensities in Aging and Dementia. / Mayda, Adriane; Yoshita, Mitsuhiro; DeCarli, Charles.

Imaging the Aging Brain. Oxford University Press, 2010.

Research output: Chapter in Book/Report/Conference proceedingChapter

Mayda, A, Yoshita, M & DeCarli, C 2010, White Matter Hyperintensities in Aging and Dementia. in Imaging the Aging Brain. Oxford University Press. https://doi.org/10.1093/acprof:oso/9780195328875.003.0017
Mayda A, Yoshita M, DeCarli C. White Matter Hyperintensities in Aging and Dementia. In Imaging the Aging Brain. Oxford University Press. 2010 https://doi.org/10.1093/acprof:oso/9780195328875.003.0017
Mayda, Adriane ; Yoshita, Mitsuhiro ; DeCarli, Charles. / White Matter Hyperintensities in Aging and Dementia. Imaging the Aging Brain. Oxford University Press, 2010.
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