White matter changes compromise prefrontal cortex function in healthy elderly individuals

Christine W Nordahl, Charan Ranganath, Andrew P. Yonelinas, Charles DeCarli, Evan Fletcher, William J. Jagust

Research output: Contribution to journalArticle

161 Citations (Scopus)

Abstract

Changes in memory function in elderly individuals are often attributed to dysfunction of the prefrontal cortex (PFC). One mechanism for this dysfunction may be disruption of white matter tracts that connect the PFC with its anatomical targets. Here, we tested the hypothesis that white matter degeneration is associated with reduced prefrontal activation. We used white matter hyperintensities (WMH), a magnetic resonance imaging (MRI) finding associated with cerebrovascular disease in elderly individuals, as a marker for white matter degeneration. Specifically, we used structural MRI to quantify the extent of WMH in a group of cognitively normal elderly individuals and tested whether these measures were predictive of the magnitude of prefrontal activity (fMRI) observed during performance of an episodic retrieval task and a verbal working memory task. We also examined the effects of WMH located in the dorsolateral frontal regions with the hypothesis that dorsal PFC WMH would be strongly associated with not only PFC function, but also with areas that are anatomically and functionally linked to the PFC in a task-dependent manner. Results showed that increases in both global and regional dorsal PFC WMH volume were associated with decreases in PFC activity. In addition, dorsal PFC WMH volume was associated with decreased activity in medial temporal and anterior cingulate regions during episodic retrieval and decreased activity in the posterior parietal and anterior cingulate cortex during working memory performance. These results suggest that disruption of white matter tracts, especially within the PFC, may be a mechanism for age-related changes in memory functioning.

Original languageEnglish (US)
Pages (from-to)418-429
Number of pages12
JournalJournal of Cognitive Neuroscience
Volume18
Issue number3
DOIs
StatePublished - Mar 2006

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Prefrontal Cortex
Gyrus Cinguli
Magnetic Resonance Imaging
Short-Term Memory
White Matter
Cerebrovascular Disorders

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Experimental and Cognitive Psychology
  • Cognitive Neuroscience

Cite this

White matter changes compromise prefrontal cortex function in healthy elderly individuals. / Nordahl, Christine W; Ranganath, Charan; Yonelinas, Andrew P.; DeCarli, Charles; Fletcher, Evan; Jagust, William J.

In: Journal of Cognitive Neuroscience, Vol. 18, No. 3, 03.2006, p. 418-429.

Research output: Contribution to journalArticle

Nordahl, Christine W ; Ranganath, Charan ; Yonelinas, Andrew P. ; DeCarli, Charles ; Fletcher, Evan ; Jagust, William J. / White matter changes compromise prefrontal cortex function in healthy elderly individuals. In: Journal of Cognitive Neuroscience. 2006 ; Vol. 18, No. 3. pp. 418-429.
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