Where to start and when to stop

Lin Tian, Andreas Matouschek

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


The activity of a handful of transcription factors, such as mammalian NF-κB, Drosophila melanogaster Cubitus interruptus and yeast Spt23 and Mga2, are regulated through partial protein degradation by the proteasome. New data now show that the proteasome activates membrane-bound Spt23 and Mga2 by initiating their proteolysis at an internal site and then degrading the proteins bidirectionally toward both ends of the polypeptide chain, modifying our ideas on how the proteasome degrades targeted substrates.

Original languageEnglish (US)
Pages (from-to)668-670
Number of pages3
JournalNature Structural and Molecular Biology
Issue number8
StatePublished - Aug 2006
Externally publishedYes

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology


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