Where to start and when to stop

Lin Tian; Andreas Matouschek

doi:10.1038/nsmb0806-668

Where to start and when to stop

Lin Tian, Andreas Matouschek

Research output: Contribution to journal › Article

7 Scopus citations

Abstract

The activity of a handful of transcription factors, such as mammalian NF-κB, Drosophila melanogaster Cubitus interruptus and yeast Spt23 and Mga2, are regulated through partial protein degradation by the proteasome. New data now show that the proteasome activates membrane-bound Spt23 and Mga2 by initiating their proteolysis at an internal site and then degrading the proteins bidirectionally toward both ends of the polypeptide chain, modifying our ideas on how the proteasome degrades targeted substrates.

Original language	English (US)
Pages (from-to)	668-670
Number of pages	3
Journal	Nature Structural and Molecular Biology
Volume	13
Issue number	8
DOIs	https://doi.org/10.1038/nsmb0806-668
State	Published - Aug 2006
Externally published	Yes

ASJC Scopus subject areas

Structural Biology
Molecular Biology

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Tian, L., & Matouschek, A. (2006). Where to start and when to stop. Nature Structural and Molecular Biology, 13(8), 668-670. https://doi.org/10.1038/nsmb0806-668

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