When timing is everything: Are placental mri examinations performed before 24 weeks' gestational age reliable?

Jeanne M. Horowitz, Senta Berggruen, Robert J. McCarthy, Melissa Chen, Cassing Hammond, Angela Trinh, Helena Gabriel

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

OBJECTIVE. The objective of our study was to determine if placental MRI examinations performed for the detection of abnormal placentation earlier than 24 weeks' gestational age (GA) are more or less reliable than examinations performed at a later GA. MATERIALS AND METHODS. Two radiologists blinded to clinical, surgical, and pathologic reports retrospectively and independently reviewed 69 placental MRI examinations for nine imaging signs associated with abnormal placentation. A consensus of the suspicion of abnormal placentation (including accreta, increta, or percreta) was determined using a 5-point (low to high suspicion) Likert scale and compared with pathologic or surgical findings or both. RESULTS. Seventeen placental MRI examinations were performed at GA 14-23 weeks, and 52 placental MRI examinations were performed at GA 24-41 weeks. Reviewer agreement (Cronbach alpha) among the nine imaging signs was 0.86 (95% CI, 0.72-0.92) and 0.92 (95% CI, 0.92-0.94) for MRI examinations at GA 14-23 weeks and GA 24-41 weeks, respectively. Pathologic or surgical evidence of abnormal placentation was found in 41% and 65% of the cases between GA 14-23 weeks and GA 24-41 weeks, respectively. The AUC for the MRI-based consensus score and the presence of abnormal placentation for GA 14-23 weeks was 0.49 (95% CI, 0.21-0.78) compared with 0.92 (95% CI, 0.83-1.0) for GA 24-41 weeks (p = 0.002). CONCLUSION. Placental MRI examinations performed before 24 weeks' GA unreliably predict abnormal placentation.

Original languageEnglish (US)
Pages (from-to)685-692
Number of pages8
JournalAmerican Journal of Roentgenology
Volume205
Issue number3
DOIs
StatePublished - Jan 1 2015

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Gestational Age
Placentation
Area Under Curve

Keywords

  • Abnormal placentation
  • Gestational age
  • MRI
  • Placenta accreta

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

When timing is everything : Are placental mri examinations performed before 24 weeks' gestational age reliable? / Horowitz, Jeanne M.; Berggruen, Senta; McCarthy, Robert J.; Chen, Melissa; Hammond, Cassing; Trinh, Angela; Gabriel, Helena.

In: American Journal of Roentgenology, Vol. 205, No. 3, 01.01.2015, p. 685-692.

Research output: Contribution to journalArticle

Horowitz, Jeanne M. ; Berggruen, Senta ; McCarthy, Robert J. ; Chen, Melissa ; Hammond, Cassing ; Trinh, Angela ; Gabriel, Helena. / When timing is everything : Are placental mri examinations performed before 24 weeks' gestational age reliable?. In: American Journal of Roentgenology. 2015 ; Vol. 205, No. 3. pp. 685-692.
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abstract = "OBJECTIVE. The objective of our study was to determine if placental MRI examinations performed for the detection of abnormal placentation earlier than 24 weeks' gestational age (GA) are more or less reliable than examinations performed at a later GA. MATERIALS AND METHODS. Two radiologists blinded to clinical, surgical, and pathologic reports retrospectively and independently reviewed 69 placental MRI examinations for nine imaging signs associated with abnormal placentation. A consensus of the suspicion of abnormal placentation (including accreta, increta, or percreta) was determined using a 5-point (low to high suspicion) Likert scale and compared with pathologic or surgical findings or both. RESULTS. Seventeen placental MRI examinations were performed at GA 14-23 weeks, and 52 placental MRI examinations were performed at GA 24-41 weeks. Reviewer agreement (Cronbach alpha) among the nine imaging signs was 0.86 (95{\%} CI, 0.72-0.92) and 0.92 (95{\%} CI, 0.92-0.94) for MRI examinations at GA 14-23 weeks and GA 24-41 weeks, respectively. Pathologic or surgical evidence of abnormal placentation was found in 41{\%} and 65{\%} of the cases between GA 14-23 weeks and GA 24-41 weeks, respectively. The AUC for the MRI-based consensus score and the presence of abnormal placentation for GA 14-23 weeks was 0.49 (95{\%} CI, 0.21-0.78) compared with 0.92 (95{\%} CI, 0.83-1.0) for GA 24-41 weeks (p = 0.002). CONCLUSION. Placental MRI examinations performed before 24 weeks' GA unreliably predict abnormal placentation.",
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N2 - OBJECTIVE. The objective of our study was to determine if placental MRI examinations performed for the detection of abnormal placentation earlier than 24 weeks' gestational age (GA) are more or less reliable than examinations performed at a later GA. MATERIALS AND METHODS. Two radiologists blinded to clinical, surgical, and pathologic reports retrospectively and independently reviewed 69 placental MRI examinations for nine imaging signs associated with abnormal placentation. A consensus of the suspicion of abnormal placentation (including accreta, increta, or percreta) was determined using a 5-point (low to high suspicion) Likert scale and compared with pathologic or surgical findings or both. RESULTS. Seventeen placental MRI examinations were performed at GA 14-23 weeks, and 52 placental MRI examinations were performed at GA 24-41 weeks. Reviewer agreement (Cronbach alpha) among the nine imaging signs was 0.86 (95% CI, 0.72-0.92) and 0.92 (95% CI, 0.92-0.94) for MRI examinations at GA 14-23 weeks and GA 24-41 weeks, respectively. Pathologic or surgical evidence of abnormal placentation was found in 41% and 65% of the cases between GA 14-23 weeks and GA 24-41 weeks, respectively. The AUC for the MRI-based consensus score and the presence of abnormal placentation for GA 14-23 weeks was 0.49 (95% CI, 0.21-0.78) compared with 0.92 (95% CI, 0.83-1.0) for GA 24-41 weeks (p = 0.002). CONCLUSION. Placental MRI examinations performed before 24 weeks' GA unreliably predict abnormal placentation.

AB - OBJECTIVE. The objective of our study was to determine if placental MRI examinations performed for the detection of abnormal placentation earlier than 24 weeks' gestational age (GA) are more or less reliable than examinations performed at a later GA. MATERIALS AND METHODS. Two radiologists blinded to clinical, surgical, and pathologic reports retrospectively and independently reviewed 69 placental MRI examinations for nine imaging signs associated with abnormal placentation. A consensus of the suspicion of abnormal placentation (including accreta, increta, or percreta) was determined using a 5-point (low to high suspicion) Likert scale and compared with pathologic or surgical findings or both. RESULTS. Seventeen placental MRI examinations were performed at GA 14-23 weeks, and 52 placental MRI examinations were performed at GA 24-41 weeks. Reviewer agreement (Cronbach alpha) among the nine imaging signs was 0.86 (95% CI, 0.72-0.92) and 0.92 (95% CI, 0.92-0.94) for MRI examinations at GA 14-23 weeks and GA 24-41 weeks, respectively. Pathologic or surgical evidence of abnormal placentation was found in 41% and 65% of the cases between GA 14-23 weeks and GA 24-41 weeks, respectively. The AUC for the MRI-based consensus score and the presence of abnormal placentation for GA 14-23 weeks was 0.49 (95% CI, 0.21-0.78) compared with 0.92 (95% CI, 0.83-1.0) for GA 24-41 weeks (p = 0.002). CONCLUSION. Placental MRI examinations performed before 24 weeks' GA unreliably predict abnormal placentation.

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KW - Gestational age

KW - MRI

KW - Placenta accreta

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