When is electrical cortical stimulation more likely to produce afterdischarges?

Hyang Woon Lee, W. R S Webber, Nathan Crone, Diana L Miglioretti, Ronald P. Lesser

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Objective: To study when afterdischarges (ADs) are more likely to occur during cortical stimulation. Methods: We examined 6250 electrical stimulation trials in 13 patients with subdural electrodes, studying whether AD occurrence during a trial was influenced by electrode pair stimulated or AD occurrence during the previous trial. In total 545 electrodes were stimulated, 119 frontal (pre-perirolandic), 289 perirolandic, 36 parietal (post-perirolandic), 95 temporal, and 6 occipital. Results: When the same electrode pair was stimulated as the prior trial, 19% produced ADs compared to 5% of trials when a different electrodes pair was stimulated (p < 0.0001). When trials showed ADs, and the next trial stimulated the same electrode pair, ADs occurred in 46% of cases, compared to 13% of trials following trials without ADs (p < 0.0001). AD probability decreased with increased inter-trial interval length only when the prior trial was at the same electrode pair and had produced an AD (p = 0.001). AD probability increased with stimulation duration, whether the trial followed a trial with (p < 0.001) or without (p < 0.0001) an AD. Conclusions: ADs were more likely to occur when an electrode pair showed ADs and was stimulated again, especially when stimulating after short inter-trial intervals or for longer duration. Significance: When ADs occur, waiting about a minute before resuming stimulation might lessen the likelihood of AD recurrence.

Original languageEnglish (US)
Pages (from-to)14-20
Number of pages7
JournalClinical Neurophysiology
Volume121
Issue number1
DOIs
StatePublished - Jan 2010
Externally publishedYes

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Electric Stimulation
Electrodes
Recurrence

Keywords

  • Afterdischarges
  • Cortical stimulation
  • Epilepsy surgery
  • Functional mapping
  • Inter-trial interval

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Physiology (medical)
  • Sensory Systems

Cite this

When is electrical cortical stimulation more likely to produce afterdischarges? / Lee, Hyang Woon; Webber, W. R S; Crone, Nathan; Miglioretti, Diana L; Lesser, Ronald P.

In: Clinical Neurophysiology, Vol. 121, No. 1, 01.2010, p. 14-20.

Research output: Contribution to journalArticle

Lee, Hyang Woon ; Webber, W. R S ; Crone, Nathan ; Miglioretti, Diana L ; Lesser, Ronald P. / When is electrical cortical stimulation more likely to produce afterdischarges?. In: Clinical Neurophysiology. 2010 ; Vol. 121, No. 1. pp. 14-20.
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