Abstract
Lymph node metastases are common in patients with advanced bladder cancer. Survival rates have apparently improved from about 15% to 30% as management evolved from lymphadenectomy plus cystectomy to multimodal therapy, but investigators have not conclusively shown the benefit of adjuvant irradiation and/or chemotherapy. If clinical staging indicates nodal metastases, we recommend primary multiagent chemotherapy with subsequent exploratory laparotomy, lymphadenectomy, and possibly cystectomy for complete responders. Patients without clinical evidence of metastases undergo complete bilateral pelvic lymphadenectomy plus cystectomy if nodes are normal, or if grossly abnormal but resectable. Patients with nodal metastases may be candidates for adjuvant chemotherapy.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 96-102 |
| Number of pages | 7 |
| Journal | Seminars in Urologic Oncology |
| Volume | 14 |
| Issue number | 2 |
| State | Published - 1996 |
| Externally published | Yes |
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Keywords
- bladder cancer
- Lymph nodes
- metastases
ASJC Scopus subject areas
- Urology
Cite this
What to do if the lymph nodes are positive. / Evans, Christopher P; Swanson, D. A.
In: Seminars in Urologic Oncology, Vol. 14, No. 2, 1996, p. 96-102.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - What to do if the lymph nodes are positive
AU - Evans, Christopher P
AU - Swanson, D. A.
PY - 1996
Y1 - 1996
N2 - Lymph node metastases are common in patients with advanced bladder cancer. Survival rates have apparently improved from about 15% to 30% as management evolved from lymphadenectomy plus cystectomy to multimodal therapy, but investigators have not conclusively shown the benefit of adjuvant irradiation and/or chemotherapy. If clinical staging indicates nodal metastases, we recommend primary multiagent chemotherapy with subsequent exploratory laparotomy, lymphadenectomy, and possibly cystectomy for complete responders. Patients without clinical evidence of metastases undergo complete bilateral pelvic lymphadenectomy plus cystectomy if nodes are normal, or if grossly abnormal but resectable. Patients with nodal metastases may be candidates for adjuvant chemotherapy.
AB - Lymph node metastases are common in patients with advanced bladder cancer. Survival rates have apparently improved from about 15% to 30% as management evolved from lymphadenectomy plus cystectomy to multimodal therapy, but investigators have not conclusively shown the benefit of adjuvant irradiation and/or chemotherapy. If clinical staging indicates nodal metastases, we recommend primary multiagent chemotherapy with subsequent exploratory laparotomy, lymphadenectomy, and possibly cystectomy for complete responders. Patients without clinical evidence of metastases undergo complete bilateral pelvic lymphadenectomy plus cystectomy if nodes are normal, or if grossly abnormal but resectable. Patients with nodal metastases may be candidates for adjuvant chemotherapy.
KW - bladder cancer
KW - Lymph nodes
KW - metastases
UR - http://www.scopus.com/inward/record.url?scp=0029934939&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029934939&partnerID=8YFLogxK
M3 - Article
C2 - 8734737
AN - SCOPUS:0029934939
VL - 14
SP - 96
EP - 102
JO - Urologic Oncology
JF - Urologic Oncology
SN - 1078-1439
IS - 2
ER -