What makes an autoantigen an autoantigen?

Chih Te Wu, M. Eric Gershwin, Paul A. Davis

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Multiple classes of proteins are modified to tailor them for specific physiological roles. The nature of these posttranslational modifications of proteins, as well as the relationships between them including those of the immune system proteins themselves, and immune system responses are reviewed. Aspects of protein posttranslational modification and their relationship to the pathogenesis of several autoimmune diseases and primary biliary cirrhosis are highlighted.

Original languageEnglish (US)
Pages (from-to)134-145
Number of pages12
JournalAnnals of the New York Academy of Sciences
Volume1050
DOIs
StatePublished - 2005

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Keywords

  • Antigens
  • Autoimmunity
  • Immune system
  • Posttranslational modification
  • Primary biliary cirrhosis
  • Protein function

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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