Wernicke's encephalopathy induced by tolazamide

Ingrid Kwee, T. Nakada

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The Wernicke-Korsakoff syndrome is a nutritional neurologic disorder that is due to thiamine deficiency. Although Wernicke's encephalopathy represents the acute phase of the syndrome, Korsakoff's psychosis represents its chronic continuum. Thiamine is a cofactor in glucose metabolism in the glycolytic and pentose phosphate pathways, and a state of thiamine deficiency is well known to be exacerbated or even precipitated by the administration of a glucose load in the patient with marginal thiamine reserves. The correction of hyperglycemia by hypoglycemic agents in diabetic patients increases short-term use of glucose in the tissues, which results in an obligatory demand for more thiamine. Therefore, such agents may also precipitate thiamine depletion and induce Werhicke's encephalopathy in the susceptible patient who has borderline thiamine reserves. The present report describes such a case, evidently caused by use of the hypoglycemic agent tolazamide (Tolinase).

Original languageEnglish (US)
Pages (from-to)599-600
Number of pages2
JournalNew England Journal of Medicine
Volume309
Issue number10
StatePublished - 1983

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Tolazamide
Wernicke Encephalopathy
Thiamine
Korsakoff Syndrome
Thiamine Deficiency
Hypoglycemic Agents
Glucose
Nutrition Disorders
Pentose Phosphate Pathway
Brain Diseases
Nervous System Diseases
Hyperglycemia

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Wernicke's encephalopathy induced by tolazamide. / Kwee, Ingrid; Nakada, T.

In: New England Journal of Medicine, Vol. 309, No. 10, 1983, p. 599-600.

Research output: Contribution to journalArticle

Kwee, Ingrid ; Nakada, T. / Wernicke's encephalopathy induced by tolazamide. In: New England Journal of Medicine. 1983 ; Vol. 309, No. 10. pp. 599-600.
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