Abstract
The Wernicke-Korsakoff syndrome is a nutritional neurologic disorder that is due to thiamine deficiency. Although Wernicke's encephalopathy represents the acute phase of the syndrome, Korsakoff's psychosis represents its chronic continuum. Thiamine is a cofactor in glucose metabolism in the glycolytic and pentose phosphate pathways, and a state of thiamine deficiency is well known to be exacerbated or even precipitated by the administration of a glucose load in the patient with marginal thiamine reserves. The correction of hyperglycemia by hypoglycemic agents in diabetic patients increases short-term use of glucose in the tissues, which results in an obligatory demand for more thiamine. Therefore, such agents may also precipitate thiamine depletion and induce Werhicke's encephalopathy in the susceptible patient who has borderline thiamine reserves. The present report describes such a case, evidently caused by use of the hypoglycemic agent tolazamide (Tolinase).
| Original language | English (US) |
|---|---|
| Pages (from-to) | 599-600 |
| Number of pages | 2 |
| Journal | New England Journal of Medicine |
| Volume | 309 |
| Issue number | 10 |
| State | Published - 1983 |
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Cite this
Wernicke's encephalopathy induced by tolazamide. / Kwee, Ingrid; Nakada, T.
In: New England Journal of Medicine, Vol. 309, No. 10, 1983, p. 599-600.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Wernicke's encephalopathy induced by tolazamide
AU - Kwee, Ingrid
AU - Nakada, T.
PY - 1983
Y1 - 1983
N2 - The Wernicke-Korsakoff syndrome is a nutritional neurologic disorder that is due to thiamine deficiency. Although Wernicke's encephalopathy represents the acute phase of the syndrome, Korsakoff's psychosis represents its chronic continuum. Thiamine is a cofactor in glucose metabolism in the glycolytic and pentose phosphate pathways, and a state of thiamine deficiency is well known to be exacerbated or even precipitated by the administration of a glucose load in the patient with marginal thiamine reserves. The correction of hyperglycemia by hypoglycemic agents in diabetic patients increases short-term use of glucose in the tissues, which results in an obligatory demand for more thiamine. Therefore, such agents may also precipitate thiamine depletion and induce Werhicke's encephalopathy in the susceptible patient who has borderline thiamine reserves. The present report describes such a case, evidently caused by use of the hypoglycemic agent tolazamide (Tolinase).
AB - The Wernicke-Korsakoff syndrome is a nutritional neurologic disorder that is due to thiamine deficiency. Although Wernicke's encephalopathy represents the acute phase of the syndrome, Korsakoff's psychosis represents its chronic continuum. Thiamine is a cofactor in glucose metabolism in the glycolytic and pentose phosphate pathways, and a state of thiamine deficiency is well known to be exacerbated or even precipitated by the administration of a glucose load in the patient with marginal thiamine reserves. The correction of hyperglycemia by hypoglycemic agents in diabetic patients increases short-term use of glucose in the tissues, which results in an obligatory demand for more thiamine. Therefore, such agents may also precipitate thiamine depletion and induce Werhicke's encephalopathy in the susceptible patient who has borderline thiamine reserves. The present report describes such a case, evidently caused by use of the hypoglycemic agent tolazamide (Tolinase).
UR - http://www.scopus.com/inward/record.url?scp=0020955533&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0020955533&partnerID=8YFLogxK
M3 - Article
C2 - 6410237
AN - SCOPUS:0020955533
VL - 309
SP - 599
EP - 600
JO - New England Journal of Medicine
JF - New England Journal of Medicine
SN - 0028-4793
IS - 10
ER -