Well-differentiated lymphocytic leukemia in a dog: long-term survival without therapy

J. W. Harvey, T. G. Terrell, D. M. Hyde, R. I. Jackson

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Well-differentiated lymphocytic r491w5 leukemia was found during routine hematologic examination of a 12-year-old female poodle with signs of anxiousness, panting and pica. The total while blood cell count was 106,900/μl and at least 90% of the leukocytes were small, normal-appearing lymphocytes. The dog was examined several times during a 23-month period before it was killed at the owner's request for conditions unrelated to the leukemia. The hematologic picture of the leukemia was essentially unchanged during this time. A deep nuclear cleft was seen in most lymphocytes examined by electron microscopy. Cell surface markers showed most blood lymphocytes to be B-cells. These cells responded poorly to mitogen stimulation.

Original languageEnglish (US)
Pages (from-to)37-47
Number of pages11
JournalVeterinary Pathology
Issue number1
StatePublished - 1981
Externally publishedYes

ASJC Scopus subject areas

  • veterinary(all)


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