Abstract
Demand and deliver: Micelles reversibly crosslinked by boronate esters (see scheme) show in vitro and in vivo stability, and thus minimize premature drug release under physiological conditions. After reaching the tumor sites, drug (stars in scheme) release is activated by cleavage of the boronate esters by the acidic conditions around the tumor or in the target cells, or by the administration of mannitol.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2864-2869 |
| Number of pages | 6 |
| Journal | Angewandte Chemie - International Edition |
| Volume | 51 |
| Issue number | 12 |
| DOIs | |
| State | Published - Mar 19 2012 |
Fingerprint
Keywords
- boronate
- controlled release
- FRET
- micelles
- nanocarriers
ASJC Scopus subject areas
- Chemistry(all)
- Catalysis
Cite this
Well-defined, reversible boronate crosslinked nanocarriers for targeted drug delivery in response to acidic pH values and cis-diols. / Li, Yuanpei; Xiao, Wenwu; Xiao, Kai; Berti, Lorenzo; Luo, Juntao; Tseng, Harry P.; Fung, Gabriel; Lam, Kit.
In: Angewandte Chemie - International Edition, Vol. 51, No. 12, 19.03.2012, p. 2864-2869.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Well-defined, reversible boronate crosslinked nanocarriers for targeted drug delivery in response to acidic pH values and cis-diols
AU - Li, Yuanpei
AU - Xiao, Wenwu
AU - Xiao, Kai
AU - Berti, Lorenzo
AU - Luo, Juntao
AU - Tseng, Harry P.
AU - Fung, Gabriel
AU - Lam, Kit
PY - 2012/3/19
Y1 - 2012/3/19
N2 - Demand and deliver: Micelles reversibly crosslinked by boronate esters (see scheme) show in vitro and in vivo stability, and thus minimize premature drug release under physiological conditions. After reaching the tumor sites, drug (stars in scheme) release is activated by cleavage of the boronate esters by the acidic conditions around the tumor or in the target cells, or by the administration of mannitol.
AB - Demand and deliver: Micelles reversibly crosslinked by boronate esters (see scheme) show in vitro and in vivo stability, and thus minimize premature drug release under physiological conditions. After reaching the tumor sites, drug (stars in scheme) release is activated by cleavage of the boronate esters by the acidic conditions around the tumor or in the target cells, or by the administration of mannitol.
KW - boronate
KW - controlled release
KW - FRET
KW - micelles
KW - nanocarriers
UR - http://www.scopus.com/inward/record.url?scp=84863230233&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84863230233&partnerID=8YFLogxK
U2 - 10.1002/anie.201107144
DO - 10.1002/anie.201107144
M3 - Article
C2 - 22253091
AN - SCOPUS:84863230233
VL - 51
SP - 2864
EP - 2869
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
SN - 1433-7851
IS - 12
ER -