Well-defined, reversible boronate crosslinked nanocarriers for targeted drug delivery in response to acidic pH values and cis-diols

Yuanpei Li, Wenwu Xiao, Kai Xiao, Lorenzo Berti, Juntao T Luo, Harry P. Tseng, Gabriel Fung, Kit S. Lam

Research output: Contribution to journalArticle

267 Scopus citations

Abstract

Demand and deliver: Micelles reversibly crosslinked by boronate esters (see scheme) show in vitro and in vivo stability, and thus minimize premature drug release under physiological conditions. After reaching the tumor sites, drug (stars in scheme) release is activated by cleavage of the boronate esters by the acidic conditions around the tumor or in the target cells, or by the administration of mannitol.

Original languageEnglish (US)
Pages (from-to)2864-2869
Number of pages6
JournalAngewandte Chemie - International Edition
Volume51
Issue number12
DOIs
StatePublished - Mar 19 2012

Keywords

  • boronate
  • controlled release
  • FRET
  • micelles
  • nanocarriers

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis

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