Well-defined, reversible boronate crosslinked nanocarriers for targeted drug delivery in response to acidic pH values and cis-diols

Yuanpei Li; Wenwu Xiao; Kai Xiao; Lorenzo Berti; Juntao T Luo; Harry P. Tseng; Gabriel Fung; Kit S. Lam

doi:10.1002/anie.201107144

Well-defined, reversible boronate crosslinked nanocarriers for targeted drug delivery in response to acidic pH values and cis-diols

Yuanpei Li, Wenwu Xiao, Kai Xiao, Lorenzo Berti, Juntao T Luo, Harry P. Tseng, Gabriel Fung, Kit S. Lam

Biochemistry and Molecular Medicine

Research output: Contribution to journal › Article › peer-review

289 Scopus citations

Abstract

Demand and deliver: Micelles reversibly crosslinked by boronate esters (see scheme) show in vitro and in vivo stability, and thus minimize premature drug release under physiological conditions. After reaching the tumor sites, drug (stars in scheme) release is activated by cleavage of the boronate esters by the acidic conditions around the tumor or in the target cells, or by the administration of mannitol.

Original language	English (US)
Pages (from-to)	2864-2869
Number of pages	6
Journal	Angewandte Chemie - International Edition
Volume	51
Issue number	12
DOIs	https://doi.org/10.1002/anie.201107144
State	Published - Mar 19 2012

Keywords

boronate
controlled release
FRET
micelles
nanocarriers

ASJC Scopus subject areas

Chemistry(all)
Catalysis

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10.1002/anie.201107144

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Well-defined, reversible boronate crosslinked nanocarriers for targeted drug delivery in response to acidic pH values and cis-diols. / Li, Yuanpei; Xiao, Wenwu; Xiao, Kai; Berti, Lorenzo; Luo, Juntao T; Tseng, Harry P.; Fung, Gabriel; Lam, Kit S.

In: Angewandte Chemie - International Edition, Vol. 51, No. 12, 19.03.2012, p. 2864-2869.

Research output: Contribution to journal › Article › peer-review

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AU - Berti, Lorenzo

AU - Luo, Juntao T

AU - Tseng, Harry P.

AU - Fung, Gabriel

AU - Lam, Kit S.

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AB - Demand and deliver: Micelles reversibly crosslinked by boronate esters (see scheme) show in vitro and in vivo stability, and thus minimize premature drug release under physiological conditions. After reaching the tumor sites, drug (stars in scheme) release is activated by cleavage of the boronate esters by the acidic conditions around the tumor or in the target cells, or by the administration of mannitol.

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KW - nanocarriers

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Well-defined, reversible boronate crosslinked nanocarriers for targeted drug delivery in response to acidic pH values and cis-diols

Abstract

Keywords

ASJC Scopus subject areas

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