Weight loss in women participating in a randomized trial of low-fat diets

Lianne Sheppard, Alan R. Kristal, Lawrence H. Kushi

Research output: Contribution to journalArticlepeer-review

187 Scopus citations


We examined weight changes over 1 and 2 y in 303 women enrolled in a low-fat dietary-intervention trial. Participants were randomly assigned to an intervention group that received intensive instruction in maintaining a low-fat diet or to a control group. After 1 y intervention-group women had decreased fat intake by 45.3 g (from 39.2% to 21.6% energy from fat) and weight by 3.1 kg (all P < 0.0001); control-group women decreased fat intake by 8.8 g (from 38.9% to 37.3% energy from fat) and weight by 0.4 kg. In both univariate analyses and multivariate models, weight loss was more strongly associated with change in percent energy from fat than with change in total energy intake. These data, which are consistent with both epidemiologic and clinical studies, suggest that body adiposity is a function both of energy balance and the proportion of energy derived from fat.

Original languageEnglish (US)
Pages (from-to)821-828
Number of pages8
JournalAmerican Journal of Clinical Nutrition
Issue number5
StatePublished - Nov 1991
Externally publishedYes


  • Diet composition
  • Dietary fat
  • Dietary intervention
  • Energy intake
  • Obesity
  • Weight loss

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)


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