Web-based accurate measurements of carotid lumen diameter and stenosis severity: An ultrasound-based clinical tool for stroke risk assessment during multicenter clinical trials

Luca Saba, Sumit K. Banchhor, Narendra D. Londhe, Tadashi Araki, John R. Laird, Ajay Gupta, Andrew Nicolaides, Jasjit S. Suri

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Background This pilot study presents a completely automated, novel, smart, cloud-based, point-of-care system for (a) carotid lumen diameter (LD); (b) stenosis severity index (SSI) and (c) total lumen area (TLA) measurement using B-mode ultrasound. The proposed system was (i) validated against manual reading taken by the Neurologist and (ii) benchmarked against the commercially available system. Method One hundred patients (73 M/27 F, mean age: 68 ± 11 years), institutional review board approved, written informed consent, consisted of left/right common carotid artery (200 ultrasound scans) were acquired using a 7.5-MHz linear transducer. Results The measured mean LD for left and right carotids were (in mm): (i) for proposed system (6.49 ± 1.77, 6.66 ± 1.70); and (ii) for manual (6.29 ± 1.79, 6.45 ± 1.63), respectively and coefficient of correlation between cloud-based automated against manual were 0.98 (P < 0.0001) and 0.99 (P < 0.0001), respectively. The corresponding TLA error, Precision-of-Merit, and Figure-of-Merit when measured against the manual were: 4.56 ± 3.54%, 96.18 ± 3.21%, and 96.85%, respectively. The AUC for the receiving operating characteristics for the cloud-based system was: 1.0. Four statistical tests such as: Two-tailed z-test, Mann-Whitney test, Kolmogorov-Smirnov (KS) and one-way ANOVA were performed to demonstrate consistency and reliability. Conclusions The proposed system is reliable, accurate, fast, completely automated, anytime-anywhere solution for multi-center clinical trials and routine vascular screening.

Original languageEnglish (US)
Pages (from-to)306-317
Number of pages12
JournalComputers in Biology and Medicine
Volume91
DOIs
StatePublished - Dec 1 2017
Externally publishedYes

Keywords

  • Carotid arteries
  • Cloud-based
  • Lumen diameter
  • Stenosis
  • Stroke
  • Total lumen area
  • Ultrasound

ASJC Scopus subject areas

  • Computer Science Applications
  • Health Informatics

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